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    GENE:

    MUC6 (Mucin 6)

    i
    Other names: MUC6, Mucin 6 Oligomeric Mucus/Gel-Forming, Gastric Mucin-6, Mucin-6, MUC-6, Mucin 6 Gastric 2
    Associations

    News

    Trials
    16d
    RNA-Seq Analysis of Nintedanib Effects on Interstitial Pneumonia in Preoperative NSCLC Patients. (PubMed, Respir Med)
    xCell2 analysis indicated reduced plasma cells and increased smooth muscle, muscle, adipocyte, and endothelial cells, suggesting normalization of tissue remodeling. Nintedanib appears to exert anti-inflammatory effects and promote tissue repair in non-tumor lung, while facilitating tissue remodeling in fibrotic areas, indicating potential benefits in patients with interstitial pneumonia and lung cancer.
    Journal
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    AREG (Amphiregulin) • MMP11 (Matrix Metallopeptidase 11) • MUC6 (Mucin 6)
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    nintedanib
    23d
    Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)
    These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
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    FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement
    26d
    Mucin Biology as a Local Diagnostic and Promising Therapeutic Target in Endometriosis: Expression and Glycosylation Profiling. (PubMed, Int J Mol Sci)
    These findings demonstrate consistent mucin dysregulation and glycan alterations, implicating their roles in epithelial adhesion, immune evasion, and lesion persistence. Mucin biology thus emerges as a promising target for diagnostic and therapeutic strategies in endometriosis.
    Journal
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    MUC1 (Mucin 1) • MUC16 (Mucin 16, Cell Surface Associated) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
    30d
    Helicobacter pylori-naïve gastric neoplasms: clinicopathological and molecular features and diagnostic challenges. (PubMed, Digestion)
    A comprehensive disease concept integrating these lesions may help resolve this diagnostic issue. As the prevalence of Hp infection continues to decline worldwide, HpNGNs are expected to emerge as a distinct disease entity, highlighting the need for refined diagnostic frameworks and risk-based surveillance strategies in the post-Hp era.
    Review • Journal • Tumor mutational burden
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    TMB (Tumor Mutational Burden) • MUC6 (Mucin 6)
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    TMB-H
    1m
    Thrombus formation in cancer patients using autopsy materials: an immunohistochemical analysis. (PubMed, Int J Clin Exp Pathol)
    These results suggest that the expression of TF in tumor tissues is involved in the pathogenesis of CAT, and furthermore, that MUC2 contributes to thrombus formation in CAT via a pathway other than TF. In the future, these immunohistochemical analyses will help predict CAT in cancers and detect hidden cancers in patients with thrombosis.
    Journal
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    MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
    2ms
    New insights in metaplasia in autoimmune gastritis. (PubMed, Histopathology)
    Oxyntic mucosa metaplasia in AIG constitutes a complex phenomenon of successive phases of cellular plasticity characterized by the appearance of a distinct pyloric-like metaplastic subtype followed by intestinal trans-differentiation. The autoimmune metaplastic background appears non-carcinogenic regarding intestinal-type adenocarcinoma development.
    Journal
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    CDX2 (Caudal Type Homeobox 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
    2ms
    Mucin phenotype-based deep learning framework for intestinal metaplasia-carcinogenesis progression prediction. (PubMed, NPJ Precis Oncol)
    Integrating these outputs with clinical variables, the MPMR-IMCP risk model significantly outperformed clinical-only models (ΔAUC = 0.050), enabling both phenotype analysis and GIM risk stratification without specialized staining. Validated in longitudinal cohorts from Chinese GC high-incidence regions, this framework offers an efficient solution for monitoring GIM malignant transformation.
    Journal
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    MME (Membrane Metalloendopeptidase) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
    3ms
    Well-differentiated HPV-independent gastric-type adenocarcinoma of the cervix: a case report and literature review. (PubMed, Front Oncol)
    It also shows positive expression of gastric-type markers such as MUC6, Mucin 5AC, and HIK1083. Imaging examination revealed the size of the lesion, depth of infiltration, the invasion of adjacent organs, and lymph node metastasis, which is beneficial for differential diagnosis, clinical staging, and the development of a treatment plan.
    Journal
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    MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
    3ms
    Immunohistochemical Classification of High-Grade Pancreatic Intraepithelial Neoplasia and Ductal Cancerization in Pancreatic Ductal Adenocarcinoma Using p53, SMAD4, and Mucin Expression. (PubMed, APMIS)
    MUC6 was positive in 17 HG-PanIN lesions (58.6%)-higher than in invasive carcinoma (18 lesions; 18.6%) and COD (8 lesions; 12.7%) (p < 0.001). This study classified CIS as COD and HG-PanIN and found that the MUC6 expression of COD and HG-PanIN differed.
    Journal
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    MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MUC6 (Mucin 6)
    3ms
    Uncovering rare somatic variants in olfactory receptor genes in Pakistani triple-negative breast cancer patients. (PubMed, BMC Cancer)
    Detection of these variants in six out of 10 cases indicates probable role of these vastly unexplored genes in the pathogenesis of triple-negative breast tumours and warrants further exploration to establish their significance as targetable sites and facilitate drug development.
    Journal
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    MUC6 (Mucin 6)
    3ms
    Case Report: A case of zolbetuximab-based chemotherapy for Claudin 18.2-positive gastric phenotype adenocarcinoma arising in Meckel's diverticulum. (PubMed, Front Oncol)
    Treatment was started with zolbetuximab plus 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX), which is typically used for CLDN18.2-positive gastric cancer, resulting in a partial response. This is the first case of zolbetuximab-based therapy applied to adenocarcinoma from a Meckel's diverticulum with a gastric phenotype due to a biomarker profile of gastric cancer. This case highlights the importance of identifying both the biomarker profile and tissue of origin of the tumor.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • CLDN18 (Claudin 18) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)
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    HER-2 negative • CLDN18.2 positive
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    5-fluorouracil • oxaliplatin • leucovorin calcium • Vyloy (zolbetuximab-clzb)
    4ms
    A Case of Adipophilin-Positive Pancreatic Intraductal Papillary Mucinous Neoplasm (IPMN) With Eosinophilia. (PubMed, Cureus)
    In addition, eosinophil infiltration was observed in the glandular ducts of the tumor, and adipophilin was expressed in the tumor cytoplasm. This case highlights the rare coexistence of adipophilin expression and eosinophilia in IPMN, necessitating further investigation.
    Journal
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    PLIN2 (Perilipin) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)