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MUC5AC (Mucin 5AC)

News alerts, weekly reports and conference planners

Practical marker-based stratification of early gastric neoplasms in older adults. (PubMed, Am J Clin Pathol)

MUC5AC/p53 immunohistochemistry is highly effective in identifying high-risk lesions. Enteroblastic differentiation is relatively common and is associated with lymphovascular invasion. These findings support the use of targeted immunohistochemistry for accurately diagnosing and managing this vulnerable and understudied age group.

4 days ago

Journal

GPC3 (Glypican 3) • SALL4 (Spalt Like Transcription Factor 4) • MUC5AC (Mucin 5AC)

Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a -/- mice. (PubMed, World J Gastrointest Oncol)

This study highlights the potential application of taurine as a therapeutic agent for treating GIM, offering a promising strategy for its clinical management.

7 days ago

Preclinical • Journal

CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • TFF3 (Trefoil factor 3) • MUC5AC (Mucin 5AC)

Human papillomavirus-associated adenoma of the anorectum. (PubMed, Histopathology)

HPV-associated anorectal adenomas are a distinct and rare entity. To the best of our knowledge, this is the first clinicopathological report of well-documented high-risk-HPV-associated anorectal adenomas. Increased awareness of this entity among pathologists will enable larger scale studies to further understand the pathogenesis of HPV-associated anorectal adenocarcinoma.

9 days ago

Journal

CDX2 (Caudal Type Homeobox 2) • MUC5AC (Mucin 5AC)

20d

A Comparative Toxicological Evaluation of Nicotine and Its Analog 6-Methyl Nicotine in E-Cigarette Aerosol Utilizing a 3D in vitro Human Respiratory Model. (PubMed, Toxicology)

Our findings reveal differential toxicological and chemical profiles for nicotine and 6-MN aerosols; however, flavorings may confer similar cytotoxicity, as measured by LDH and metabolic activity, in 6-MN formulations as they do in those with nicotine. Thus, 6-MN is not a "safer" nicotine alternative.

20 days ago

Preclinical • Journal

IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CDH1 (Cadherin 1) • CCL11 (C-C Motif Chemokine Ligand 11) • IL4 (Interleukin 4) • TP53BP1 (Tumor Protein P53 Binding Protein 1) • MUC5AC (Mucin 5AC) • OCLN (Occludin)

23d

Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)

These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.

23 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)

FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement

26d

Differentiation and functionality of human bronchial epithelial cells in an air-liquid interface culture are modified by irradiation exposure. (PubMed, Front Public Health)

Radiation-induced transition processes, particularly UJT, may underlie the altered permeability. Non-cancer effects were most pronounced at higher doses, with stronger responses to X-ray exposure than to α-particle exposure, whereas lower doses, which were still significantly higher than the radiation exposure of a radon spa therapy, had no significant effect.

26 days ago

Journal

MUC5AC (Mucin 5AC)

26d

Mucin Biology as a Local Diagnostic and Promising Therapeutic Target in Endometriosis: Expression and Glycosylation Profiling. (PubMed, Int J Mol Sci)

These findings demonstrate consistent mucin dysregulation and glycan alterations, implicating their roles in epithelial adhesion, immune evasion, and lesion persistence. Mucin biology thus emerges as a promising target for diagnostic and therapeutic strategies in endometriosis.

26 days ago

Journal

MUC1 (Mucin 1) • MUC16 (Mucin 16, Cell Surface Associated) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)

Clinicopathological features of anaplastic lymphoma kinase-rearranged lung adenocarcinoma initially misdiagnosed with invasive mucinous adenocarcinoma - a retrospective study. (PubMed, Pol J Pathol)

Next-generation sequencing analysis confirmed ALK rearrangements in 3 cases. Accurate identification of this specific subtype of lung adenocarcinoma is essential for administering appropriate treatment and reducing the risk of potential misdiagnosis.

1 month ago

Retrospective data • Journal

ALK (Anaplastic lymphoma kinase) • TTF1 (Transcription Termination Factor 1) • NKX2-1 (NK2 Homeobox 1) • NAPSA (Napsin A Aspartic Peptidase) • HNF1A (HNF1 Homeobox A) • MUC5AC (Mucin 5AC)

ALK rearrangement

Biologically interpretable deep learning-derived MRI phenotypes reveal lymph node involvement and neoadjuvant therapy response in intrahepatic cholangiocarcinoma. (PubMed, Hepatology)

The SwinU-CliRad model can serve as a biologically interpretable tool for LN risk stratification in iCCA surgical candidates, with high-risk patients identified by the model potentially deriving benefit from NAT.

1 month ago

Journal

KRAS (KRAS proto-oncogene GTPase) • MUC5AC (Mucin 5AC)

KRAS mutation

Thrombus formation in cancer patients using autopsy materials: an immunohistochemical analysis. (PubMed, Int J Clin Exp Pathol)

These results suggest that the expression of TF in tumor tissues is involved in the pathogenesis of CAT, and furthermore, that MUC2 contributes to thrombus formation in CAT via a pathway other than TF. In the future, these immunohistochemical analyses will help predict CAT in cancers and detect hidden cancers in patients with thrombosis.

1 month ago

Journal

MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)

2ms

AutoEpiCollect 2.0: A Web-Based Machine Learning Tool for Personalized Peptide Cancer Vaccine Design. (PubMed, Molecules)

Furthermore, by applying RNAseq in a standardized workflow, the approach enables both patient-specific and population-level vaccine design, based on statistically frequent gene variants observed across tumor datasets. AutoEpiCollect 2.0 is freely available as a website based tool for user to design vaccine.

2 months ago

Journal • BRCA Biomarker

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • BRCA2 (Breast cancer 2, early onset) • AHNAK2 (AHNAK Nucleoprotein 2) • MUC5AC (Mucin 5AC)

ER positive • HER-2 negative • HER-2 negative + AR positive + ER positive • HER-2 negative + ER positive

2ms

Derazantinib enhances gemcitabine efficacy in PDAC by attenuating the NF-κB and MAPK pathways to suppress MUC5AC expression. (PubMed, Med Oncol)

Derazantinib treatment enhanced the sensitivity to GEM by attenuating the NF-κB and MAPK pathways to inhibit MUC5AC expression. Therefore, derazantinib may be a promising chemotherapeutic adjuvant for treating PDAC, particularly for patients with GEM resistance.

2 months ago

Journal

FGFR2 (Fibroblast growth factor receptor 2) • FGFR3 (Fibroblast growth factor receptor 3) • MUC5AC (Mucin 5AC)

gemcitabine • derazantinib (ARQ 087)