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    GENE:

    MUC2 (Mucin 2)

    i
    Other names: MUC2, Mucin 2, Oligomeric Mucus/Gel-Forming, Mucin 2, Intestinal/Tracheal, Mucin-2, MUC-2, SMUC, Intestinal Mucin-2, MLP
    3d
    Glutamine alleviates radiation-induced intestinal injury in rats via the mTOR/Notch1 axis. (PubMed, Front Oncol)
    Pharmacologic interventions using rapamycin and Jagged-1 further validated that Gln modulates the mTOR/Notch1 signaling cascade, leading to increased MUC2 expression and improved mucosal integrity. Collectively, these results demonstrate that Gln confers robust protection against RIII by regulating the mTOR/Notch1 axis, alleviating Notch1 overactivation, and promoting GC differentiation. These findings provide valuable mechanistic insight and experimental support for Gln as a potential therapeutic agent to prevent or mitigate radiation-induced intestinal injury.
    Preclinical • Journal
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    NOTCH1 (Notch 1) • KLF4 (Kruppel-like factor 4) • EIF4EBP1 (Eukaryotic translation initiation factor 4E binding protein 1) • MUC2 (Mucin 2) • LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5)
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    sirolimus
    3d
    Maternal curcumin supplementation alleviates intestinal inflammation of Escherichia coli-infected offspring via modulating gut microbiome in chickens. (PubMed, Anim Nutr)
    Concurrently, maternal CUR increased the relative abundance of Lactobacillus (P < 0.05), which was negatively correlated with intestinal inflammation and oxidative stress. The present study showed that maternal CUR supplementation can alleviate intestinal inflammation in offspring chickens, which may be mediated by regulating gut microbiota composition.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • IL22 (Interleukin 22) • MUC2 (Mucin 2) • TJP1 (Tight Junction Protein 1) • OCLN (Occludin)
    7d
    Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a -/- mice. (PubMed, World J Gastrointest Oncol)
    This study highlights the potential application of taurine as a therapeutic agent for treating GIM, offering a promising strategy for its clinical management.
    Preclinical • Journal
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    CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • TFF3 (Trefoil factor 3) • MUC5AC (Mucin 5AC)
    7d
    Vitamin D3 mediates amelioration of ulcerative colitis via the TRPV1-MAPK signaling pathway. (PubMed, Front Immunol)
    Consequently, this regulatory cascade led to a significant decrease in pro-inflammatory cytokines, including Interleukin-1Beta (IL-1β), Interleukin-6 (IL-6), and Tumor Necrosis Factor-Alpha (TNF-α), and concurrently restored intestinal barrier function by upregulating the expression of Occludin and Mucin2 (Muc2). This study elucidates a protective role of VD3 in UC, whereby it coordinately regulates immune responses and barrier function via the TRPV1-MAPK signaling pathway, providing a novel theoretical and experimental foundation for VD3-based therapy for UC.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) • IL1B (Interleukin 1, beta) • MUC2 (Mucin 2) • OCLN (Occludin)
    8d
    Endocrine carcinoma with amphicrine carcinoma component at esophagogastric junction. (PubMed, Clin J Gastroenterol)
    Additional surgery confirmed no residual tumor or lymph node metastasis. Given the rarity of amphicrine carcinoma and the limited understanding of its clinical behavior, further research is necessary to determine its prognosis and optimal management strategies.
    Journal
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    NCAM1 (Neural cell adhesion molecule 1) • MUC2 (Mucin 2) • SYP (Synaptophysin)
    17d
    Bifidobacterium Breve SHMB 8001 Alleviates DSS-Induced Colitis in Mice Via Modulating the Intestinal Barrier and Gut Microbiota. (PubMed, J Food Sci)
    B. breve SHMB 8001 represents a potential probiotic strain for alleviating colitis via normalizing intestinal homeostasis.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL2RA (Interleukin 2 receptor, alpha) • CD4 (CD4 Molecule) • CLDN1 (Claudin 1) • FOXP3 (Forkhead Box P3) • IL1B (Interleukin 1, beta) • MUC2 (Mucin 2) • ISG20 (Interferon Stimulated Exonuclease Gene 20) • OCLN (Occludin)
    18d
    Evaluation of Indigo Naturalis Prepared Using a Novel Method: Anti-Inflammatory Activities Against Colonic Cancer Cell Lines. (PubMed, Mediators Inflamm)
    The possible mechanism of NIN on UC could be explained starting from the inflammation-cancer transformation. Furthermore, comprehensive research is expected between inflammation and cancer development.
    Preclinical • Journal
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    RNF43 (Ring Finger Protein 43) • IL1B (Interleukin 1, beta) • MUC2 (Mucin 2) • AXIN2 (Axin 2) • LGR5 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 5)
    23d
    Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)
    These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
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    FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement
    24d
    The Role of Gut Microbiota and Mucin Barrier in the Pathogenesis of Colorectal Cancer. (PubMed, Curr Issues Mol Biol)
    This review first introduces the structure and function of the colonic mucus barrier and then discusses how gut microbiota in different areas promote the development of CRC by disrupting the mucus layer. Finally, we examine translational opportunities for exploiting microbiota-mucus barrier interactions in CRC therapy.
    Review • Journal
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    MUC2 (Mucin 2)
    25d
    Akkermansia muciniphila Ameliorates Chronic Sleep Deprivation-Induced Glucose Intolerance and Inflammatory Cytokine Activation. (PubMed, Front Biosci (Landmark Ed))
    A. muciniphila supplementation effectively ameliorated CSD-induced glucose intolerance, reduced the serum levels of LPS and proinflammatory cytokines (IL-6, TNF-α, and IL-1β), and restored intestinal barrier integrity by upregulating MUC2 and ZO-1 expression in colon tissues.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • MUC2 (Mucin 2) • TJP1 (Tight Junction Protein 1)
    26d
    Berberine augments the secretory function of salivary gland in homeostasis and after radiation exposure. (PubMed, Front Immunol)
    Additionally, BBR preserved cellular proliferation, decreased TUNEL+ apoptotic cells and the inflammatory response in SMG tissues and organoids in HNR-induced xerostomia models. In conclusion, this study demonstrates that BBR can increase saliva secretion in healthy and HNR mice, indicating its potentiality for the treatment of radiation-induced xerostomia.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1) • PCNA (Proliferating cell nuclear antigen) • GSK3B (Glycogen Synthase Kinase 3 Beta) • IL1B (Interleukin 1, beta) • MUC2 (Mucin 2) • SLC12A2 (Solute Carrier Family 12 Member 2)
    26d
    Mucin Biology as a Local Diagnostic and Promising Therapeutic Target in Endometriosis: Expression and Glycosylation Profiling. (PubMed, Int J Mol Sci)
    These findings demonstrate consistent mucin dysregulation and glycan alterations, implicating their roles in epithelial adhesion, immune evasion, and lesion persistence. Mucin biology thus emerges as a promising target for diagnostic and therapeutic strategies in endometriosis.
    Journal
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    MUC1 (Mucin 1) • MUC16 (Mucin 16, Cell Surface Associated) • MUC2 (Mucin 2) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6)