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    BIOMARKER:

    MUC16 overexpression

    i
    Other names: MUC16, Mucin 16, Cell Surface Associated, Ovarian Cancer-Related Tumor Marker CA125, Ovarian Carcinoma Antigen CA125, Mucin-16, CA125, CA125 Ovarian Cancer Antigen, Mucin-16 Short Isoform, Mucin-16 Long Isoform, CA-125, MUC-16
    Entrez ID:
    94025
    Related biomarkers:
    Expression
    Mutation
    Others
    2ms
    Structural basis for antibody recognition of the proximal MUC16 ectodomain. (PubMed, J Ovarian Res)
    Together, our studies offer insight into antibody-MUC16 ectodomain interaction and advance our ability to design agents with potentially improved therapeutic properties over anti-CA125 moiety antibodies.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    MUC16 overexpression • MUC1 overexpression • MUC16 expression
    10ms
    Fabrication of mesoporous silica nanoparticles for targeted delivery of sunitinib to ovarian cancer cells. (PubMed, Bioimpacts)
    DAPI staining showed apoptosis induction upon exposure to targeted MSNP in MUC16 positive OVCAR-3 cells. According to our results, the engineered NSs could be considered an effective multifunctional targeted drug delivery platform for the mucin 16 overexpressing cells.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    MUC16 overexpression • MUC1 overexpression • MUC16 expression
    |
    Sutent (sunitinib)
    10ms
    Overexpression of MUC16 (CA125) in extramammary Paget’s disease (WCD 2023)
    MUC16 may be a meaningful molecule reflecting the presence of distant metastasis in EMPD
    Late-breaking abstract
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    MUC16 overexpression • MUC1 overexpression • MUC16 expression
    almost2years
    Multifunctional Magnetic Nanoparticles for MRI-guided Co-delivery of Erlotinib and L-Asparaginase to Ovarian Cancer. (PubMed, J Microencapsul)
    In addition, T2-weight MR images of ovarian cancer-bearing mice indicated significant signal intensity changes at the tumor site 4 h after intravenous injection compared to the non-target MNPs. Our data suggest ERL/SPION-Val-PEG NPs as an image-guided co-drug delivery system for ovarian cancer.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated)
    |
    MUC16 overexpression • MUC1 overexpression • MUC16 expression
    |
    erlotinib
    almost2years
    MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2 Associated Cell Adhesion. (PubMed, Mol Cancer Res)
    Overall, the findings indicate that MUC16 regulates NRP2 and induces metastasis in PDAC. Implications: This study shows that MUC16 plays a critical role in PDAC liver metastasis by mediating NRP2 regulation by JAK2/STAT1 axis, thereby paving the way for future therapy efforts for metastatic PDAC.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated) • STAT1 (Signal Transducer And Activator Of Transcription 1)
    |
    MUC16 overexpression • MUC1 overexpression • MUC16 expression
    over2years
    Circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway. (PubMed, BMC Anesthesiol)
    Circ_MUC16 overexpression alleviated the effects of Propofol to promote the aggressive behaviors of ovarian cancer by targeting the miR-1182/S100B network.
    Journal
    |
    MUC16 (Mucin 16, Cell Surface Associated) • MIR182 (MicroRNA 182)
    |
    MUC16 overexpression • MUC16 expression