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GENE:

MTUS1 (Microtubule Associated Scaffold Protein 1)

News alerts, weekly reports and conference planners

4ms

In vitro and in silico analysis of the anti-proliferative effects of Spirulina platensis on A549 lung cancer cells. (PubMed, Sci Rep)

In addition to the kinetic and MAP pathways, docking analysis confirmed that S. platensis binds with the highest affinity to the predicted active sites of the tumor receptor IL-F3, thereby validating its antitumor activity. In conclusion, great suppression in the virulence of lung cancer was reported following treatment with S. platensis, illustrating its suspected mechanism of action, safety profile, kinetic properties, molecular docking results, toxicity, and internal pathways.

4 months ago

Preclinical • Journal • IO biomarker

EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • BAX (BCL2-associated X protein) • BRMS1 (BRMS1 Transcriptional Repressor And Anoikis Regulator) • MTUS1 (Microtubule Associated Scaffold Protein 1) • SHOX2 (SHOX Homeobox 2)

5ms

YTHDF2 drives oral squamous cell carcinoma progression via m6A-dependent degradation of MTUS1/ATIP1 mRNA and mitochondrial dysregulation. (PubMed, Cell Signal)

These findings establish YTHDF2 as a driver of OSCC progression through m6A-dependent suppression of MTUS1/ATIP1, linking mitochondrial dysregulation to tumorigenesis. Our study proposes therapeutic targeting of the YTHDF2-MTUS1/ATIP1 axis to improve OSCC management.

5 months ago

Journal

MTUS1 (Microtubule Associated Scaffold Protein 1) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)

8ms

Mitochondrial Tumor Suppressor 1A Attenuates Myocardial Infarction Injury by Maintaining the Coupling Between Mitochondria and Endoplasmic Reticulum. (PubMed, Circulation)

Our study demonstrates that Mtus1A is crucial for modulating MI-induced cardiac remodeling by preserving ER-mitochondria communication and ameliorating mitochondrial function in cardiomyocytes. Mtus1A may serve as a potential therapeutic target for treating heart failure after MI.

8 months ago

Journal

HSPA9 (Heat Shock Protein Family A (Hsp70) Member ) • MTUS1 (Microtubule Associated Scaffold Protein 1) • VDAC1 (Voltage Dependent Anion Channel 1)

11ms

Integrative eQTL and Mendelian randomization analysis reveals key genetic markers in mesothelioma. (PubMed, Respir Res)

This integrative eQTL and Mendelian randomization analysis provides evidence of a positive causal association between 14 key co-expressed genes and mesothelioma genetically. These disease critical genes are implicated in correlations with biological processes and infiltrated immune cells related to mesothelioma. Moreover, our study lays a theoretical foundation for further research into the mechanisms of mesothelioma and potential clinical applications.

11 months ago

Journal

TACC3 (Transforming acidic coiled-coil containing protein 3) • CD4 (CD4 Molecule) • EPAS1 (Endothelial PAS domain protein 1) • ITGAM (Integrin, alpha M) • CPA3 (Carboxypeptidase A3) • ALOX15 (Arachidonate 15-Lipoxygenase) • MTUS1 (Microtubule Associated Scaffold Protein 1)

1year

FTO-mediated demethylation of MTUS1/ATIP1 promotes tumor progression in head and neck squamous cell carcinoma. (PubMed, BMC Cancer)

Our research elucidated the functional importance of FTO-mediated m6A demethylation of MTUS1/ATIP1, suggesting that targeting the FTO-MTUS1/ATIP1 axis could be a prospective novel approach for treating HNSCC.

1 year ago

Journal

FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • MTUS1 (Microtubule Associated Scaffold Protein 1)

FTO expression

almost2years

Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer. (PubMed, World J Gastrointest Oncol)

We constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients, contributing to the development of individualized treatment for colon cancer.

almost 2 years ago

Journal • IO biomarker

TSC1 (TSC complex subunit 1) • CD4 (CD4 Molecule) • MTUS1 (Microtubule Associated Scaffold Protein 1)

almost2years

Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma. (PubMed, Int J Biol Sci)

MTUS1/ATIP1 activated ROS, recruiting Bax to mitochondria, facilitating cytochrome c release to the cytosol to activate caspase-3, and inducing GSDME-dependent pyroptotic death in HNSCC cells. Our findings showed that MTUS1/ATIP1 localized in the outer mitochondrial membrane in HNSCC cells and mediated anticancer effects through ROS-induced pyroptosis, which may provide a novel therapeutic strategy for HNSCC treatment.

almost 2 years ago

Journal

CASP3 (Caspase 3) • GSDME (Gasdermin E) • MFN2 (Mitofusin 2) • MTUS1 (Microtubule Associated Scaffold Protein 1)

almost2years

Microtubule-associated tumor suppressor 1 inhibits hemin-induced apoptosis of vascular endothelial cells via hemeoxygenase 1 (PubMed, Sheng Li Xue Bao)

And the MTUS1 knockdown mediated decreased 293T cells viability induced by hemin could be partly rescued by NRF2 overexpression (P < 0.01). These results suggest that MTUS1 can inhibit hemin-induced apoptosis of HUVEC, and the mechanism maybe related to MTUS1/NRF2/HMOX1 pathway.

almost 2 years ago

Journal

HMOX1 (Heme Oxygenase 1) • MTUS1 (Microtubule Associated Scaffold Protein 1)

HMOX1 expression

2years

Long non-coding RNA PRR7-AS1 promotes osteosarcoma progression via binding RNF2 to transcriptionally suppress MTUS1. (PubMed, Front Oncol)

Rescue experiments confirmed MTUS1 as a downstream direct target of PRR7-AS1 and RNF2. We identified lncRNA PRR7-AS1 as an important oncogene in osteosarcoma progression, indicating that it may be a potential target for diagnosis and prognosis of osteosarcoma.

2 years ago

Journal

MTUS1 (Microtubule Associated Scaffold Protein 1) • PRR7-AS1 (PRR7 Antisense RNA 1)

over2years

A Network of 17 Microtubule-Related Genes Highlights Functional Deregulations in Breast Cancer. (PubMed, Cancers (Basel))

A Systems Biology approach highlighted three major functional networks connecting the 17 MT-Rel genes and their partners, which are centered on spindle assembly, chromosome segregation and cytokinesis. Our studies identified mitotic Aurora kinases and their substrates as major targets for therapeutic approaches against breast cancer.

over 2 years ago

Journal

AURKB (Aurora Kinase B) • KIF11 (Kinesin Family Member 11) • KIFC1 (Kinesin Family Member C1) • MAPT (Microtubule Associated Protein Tau) • MAST4 (Microtubule Associated Serine/Threonine Kinase Family Member 4) • KIF20A (Kinesin Family Member 20A) • KIF2C (Kinesin Family Member 2C) • KIF4A (Kinesin Family Member 4A) • MTUS1 (Microtubule Associated Scaffold Protein 1) • RACGAP1 (Rac GTPase activating protein 1) • STMN1 (Stathmin 1) • GTSE1 (G2 And S-Phase Expressed 1) • KIF15 (Kinesin Family Member 15)

almost3years

Long Noncoding RNA MIR600HG Binds to MicroRNA-125a-5p to Prevent Pancreatic Cancer Progression Via Mitochondrial Tumor Suppressor 1-Dependent Suppression of Extracellular Regulated Protein Kinases Signaling Pathway. (PubMed, Pancreas)

Taken together, MIR600HG acts as an inhibitor for PC progression by upregulating miR-125a-5p-mediated MTUS1 through extracellular regulated protein kinases pathway.

almost 3 years ago

Journal

MIR125A (MicroRNA 125a) • MTUS1 (Microtubule Associated Scaffold Protein 1)

almost3years

Low MTUS1 Protein Expression Is Associated with Poor Survival in Patients with Colorectal Adenocarcinoma. (PubMed, Diagnostics (Basel))

Low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.

almost 3 years ago

Journal

MTUS1 (Microtubule Associated Scaffold Protein 1)