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    Ad-SGE-REIC

    i
    Other names: MTG201, Ad-SGE-REIC, MTG-201, REIC/Dkk-3, Ad5-SGE-REIC/Dkk3, Ad5-SGE-REIC/Dkk-3, DKK3 gene therapy, REIC/Dkk-3 gene therapy, REIC gene therapy, Ad-REIC/Dkk-3, Ad-SGE-DKK3/REIC gene therapy
    Associations

    News

    Trials
    Company:
    Momotaro-Gene
    Drug class:
    DKK3 stimulant
    Associations

    News

    Trials
    almost3years
    PD-1 blockade augments CD8 T cell dependent antitumor immunity triggered by Ad-SGE-REIC in Egfr-mutant lung cancer. (PubMed, Lung Cancer)
    Ad-SGE-REIC induced systemic antitumor immunity by modifying the TME status from non-inflamed to inflamed, with infiltration of CD8 T cells. Additionally, in Egfr-mutant lung cancer, this effect was enhanced by PD-1 blockade. These findings pave the way to establish a novel combined immunotherapy strategy with Ad-SGE-REIC and anti-PD-1 antibody for lung cancer with a non-inflamed TME.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • CD8 (cluster of differentiation 8) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3)
    |
    EGFR mutation
    |
    Ad-SGE-REIC
    over3years
    Combination of Ad-SGE-REIC and bevacizumab modulates glioma progression by suppressing tumor invasion and angiogenesis. (PubMed, PLoS One)
    These results suggest that the combination therapy of Ad-SGE-REIC and bevacizumab exerts anti-glioma effects by suppressing the angiogenesis and invasion of tumors. Combined Ad-SGE-REIC and bevacizumab might be a promising strategy for the treatment of malignant glioma.
    Journal
    |
    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3)
    |
    Avastin (bevacizumab) • Ad-SGE-REIC
    almost4years
    Engineering Cancer/Testis Antigens With Reversible S-Cationization to Evaluate Antigen Spreading. (PubMed, Front Oncol)
    An immune monitoring study was conducted using the serum samples on an adenovirus-mediated REIC/Dkk-3 gene therapy clinical trial that showed a successful clinical response in metastatic castration-resistant prostate cancer...Thus, quantitative monitoring of anti-CTA antibody biomarkers can be used to evaluate the cancer-immunity cycle. A quality-certified serum autoantibody monitoring system is a powerful tool for developing and evaluating cancer immunotherapy.
    Journal • IO biomarker
    |
    DKK3 (Dickkopf WNT Signaling Pathway Inhibitor 3)
    |
    Ad-SGE-REIC