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    BIOMARKER:

    MTA2 overexpression

    i
    Other names: MTA2, Metastasis Associated 1 Family Member 2, Metastasis Associated Gene Family, Member 2, P53 Target Protein In Deacetylase Complex, Metastasis-Associated Protein MTA2, Metastasis-Associated 1-Like 1, MTA1-L1 Protein, MTA1L1, PID, Metastasis -Associated Gene 1-Like 1, Metastasis-Associated Protein 2, MTA1-L1
    Entrez ID:
    9219
    Related biomarkers:
    Expression
    over1year
    MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression. (PubMed, Aging (Albany NY))
    Overall, our study suggests that MTA2 knockdown suppresses osteosarcoma cell metastasis by decreasing uPA expression via ERK signaling. This finding provides new insight into potential treatment strategies against osteosarcoma metastasis by targeting MTA2.
    Journal
    |
    MTA2 (Metastasis Associated 1 Family Member 2)
    |
    MTA2 expression • MTA2 overexpression
    over2years
    Prognostic, Immunological, and Mutational Analysis of MTA2 in Pan-Cancer and Drug Screening for Hepatocellular Carcinoma. (PubMed, Biomolecules)
    Our study demonstrated that MTA2 plays crucial roles in tumor progression and tumor immunity, and it could be used as a prognostic marker for various malignancies. MK-886 might be a powerful drug for HCC.
    Preclinical • Journal • Tumor mutational burden • Pan tumor
    |
    TMB (Tumor Mutational Burden) • CD4 (CD4 Molecule) • MTA2 (Metastasis Associated 1 Family Member 2)
    |
    MTA2 expression • MTA2 overexpression
    over3years
    Epigenetic Regulation of NF-kB in Breast Cancer: the Role in Drug Resistance (EACR 2022)
    Material and Methods MCF7 breast cancer cells were transfected with MTA2 overexpression vector and then treated with Doxorubicin or Paclitaxel to determine their cytotoxicity. Conclusion The epigenetic regulation of NFKB1 using MTA2 mimics has shown to increase the sensitivity of breast cancer cell lines to neoadjuvant chemotherapeutic drugs. This may present a promising solution to overcome drug resistance.
    IO biomarker
    |
    MTA2 (Metastasis Associated 1 Family Member 2) • RELA (RELA Proto-Oncogene)
    |
    NFKB1 expression • MTA2 expression • MTA2 overexpression
    |
    paclitaxel • doxorubicin hydrochloride