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    BIOMARKER:

    MSI-H/dMMR + CD74 overexpression

    i
    Other names: CD74, CD74 Molecule, CD74 Antigen (Invariant Polypeptide Of Major Histocompatibility Complex Class II Antigen-Associated), CD74 Molecule Major Histocompatibility Complex Class II Invariant Chain, HLA Class II Histocompatibility Antigen Gamma Chain, HLA-DR Antigens-Associated Invariant Chain, Gamma Chain Of Class II Antigens, Ia-Associated Invariant Chain, MHC HLA-DR Gamma Chain, HLA-DR-Gamma, DHLAG, P33, Ia Antigen-Associated Invariant Chain, CD74 Antigen, Ia-GAMMA, HLADG, II, Ii, MSI-H, Microsatellite instability - high, dMMR
    Entrez ID:
    972
    Related biomarkers:
    Expression
    Mutation
    Fusion
    Others
    over1year
    Analysis of HLA gene expression in patients with dMMR/MSI-H colorectal carcinoma resistant to immune checkpoint inhibitors. (ASCO-GI 2023)
    " We identified 1549 patients with dMMR/MSI-H CRC; 242 patients of these had received pembrolizumab or nivolumab. We identify elevated expression of HLA genes involved in formation of the MHC-II complex as a potential biomarker of improved response to immunotherapy that could, if further validated, optimize patient selection for ICI in CRC."
    Checkpoint inhibition • Clinical
    |
    PD-L1 (Programmed death ligand 1) • MSI (Microsatellite instability) • CD74 (CD74 Molecule) • HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1) • HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1) • HLA-B (Major Histocompatibility Complex, Class I, B) • HLA-DPB1 (Major Histocompatibility Complex, Class II, DP Beta 1) • HLA-DQA1 (Major Histocompatibility Complex, Class II, DQ Alpha 1) • HLA-DPA1 (Major Histocompatibility Complex, Class II, DP Alpha 1)
    |
    PD-L1 expression • MSI-H/dMMR • MHC-II expression • MSI-H/dMMR + CD74 overexpression • MSI-H/dMMR + HLA-B overexpression • MSI-H/dMMR + HLA-DPA1 overexpression • MSI-H/dMMR + HLA-DQA1 overexpression • MSI-H/dMMR + HLA-DQB1 overexpression • MSI-H/dMMR + HLA-DRB1 overexpression
    |
    VENTANA PD-L1 (SP142) Assay • MI Tumor Seek™
    |
    Keytruda (pembrolizumab) • Opdivo (nivolumab)