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DRUG:

Undisclosed MSC-derived Exosomes with KrasG12D siRNA

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Other names: Undisclosed MSC-derived Exosomes with KrasG12D siRNA, mesenchymal stromal cells-derived exosomes with KRAS G12D siRNA, KrasG12D siRNA-loaded Mesenchymal Stromal Cells-derived Exosomes
Associations
Company:
UT MD Anderson Cancer Center
Drug class:
KRAS G12D inhibitor, Small interfering RNA inhibitor
Associations
1year
NCI-2018-01441: iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation (clinicaltrials.gov)
P1, N=15, Active, not recruiting, M.D. Anderson Cancer Center | Recruiting --> Active, not recruiting | N=28 --> 15 | Trial completion date: Jun 2023 --> Apr 2025 | Trial primary completion date: Jun 2023 --> Apr 2025
Enrollment closed • Enrollment change • Trial completion date • Trial primary completion date • Stroma • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12D • KRAS G12
|
Undisclosed MSC-derived Exosomes with KrasG12D siRNA
over1year
NCI-2018-01441: iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation (clinicaltrials.gov)
P1, N=28, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Mar 2023 --> Jun 2023 | Trial primary completion date: Mar 2023 --> Jun 2023
Trial completion date • Trial primary completion date • Stroma • Metastases
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12D • KRAS G12
|
Undisclosed MSC-derived Exosomes with KrasG12D siRNA
over2years
NCI-2018-01441: iExosomes in Treating Participants With Metastatic Pancreas Cancer With KrasG12D Mutation (clinicaltrials.gov)
P1, N=28, Recruiting, M.D. Anderson Cancer Center | Trial completion date: Mar 2022 --> Mar 2023 | Trial primary completion date: Mar 2022 --> Mar 2023
Trial completion date • Trial primary completion date
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12D • KRAS G12
|
Undisclosed MSC-derived Exosomes with KrasG12D siRNA
over3years
Enrollment open • Clinical
|
KRAS (KRAS proto-oncogene GTPase)
|
KRAS mutation • KRAS G12D • KRAS G12
|
FoundationOne® CDx
|
Undisclosed MSC-derived Exosomes with KrasG12D siRNA