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    GENE:

    MRTFA (Myocardin Related Transcription Factor A)

    i
    Other names: MRTFA, Myocardin Related Transcription Factor A, MRTF-A, MAL, KIAA1438, BSAC, MKL1, MKL, Megakaryoblastic Leukemia (Translocation) 1, Myocardin-Related Transcription Factor A, Megakaryocytic Acute Leukemia Protein, Megakaryoblastic Leukemia 1 Protein, Basic, SAP And Coiled-Coil Domain, MKL/Myocardin-Like Protein 1, Megakaryocytic Acute Leukemia, Alternative Protein MKL1
    Associations

    News

    Trials
    17d
    Ionic Regulation of Mechanosurveillance and Metastasis via the MRTFA/KCNMB1 Axis. (PubMed, bioRxiv)
    Importantly, pharmacological activation of BK channels reduced metastatic burden in mice and improved lysis of cancer cells by cytotoxic T-lymphocytes. These results highlight the unique ionic regulation of stiffness in cancer cells and point to BK channel agonism as a new therapeutic approach in cancer.
    Journal
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    MRTFA (Myocardin Related Transcription Factor A)
    24d
    Myo1f regulates monocyte adhesion and contributes to atherosclerosis via MRTFA-dependent ITGB2 expression. (PubMed, Redox Biol)
    Our data indicate that Myo1f regulates monocyte adhesion and contributes to the pathogenesis of atherosclerosis by recruiting EPLINα, which stabilizes F-actin. This stabilization enhances MRTFA nuclear translocation, thereby promoting ITGB2 transcription.
    Journal
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    APOE (Apolipoprotein E) • ITGB2 (Integrin Subunit Beta 2) • MYO1F (Myosin IF) • MRTFA (Myocardin Related Transcription Factor A)
    2ms
    Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors. (PubMed, Cell Commun Signal)
    This study demonstrates that INS, IGF-1, and IGF-2 regulate Rho GTPase and MRTFA activation, thereby contributing to the control of actin cytoskeletal dynamics in neuronal cells. Given the role of INS and IGFs in neuronal survival and neurodegenerative conditions, elucidating these mechanisms is of critical importance, as it offers insights into disease pathogenesis and potential therapeutic targets.
    Journal
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    IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2) • CDC42 (Cell Division Cycle 42) • MRTFA (Myocardin Related Transcription Factor A)
    3ms
    Filamin a binds deleted in liver cancer 1 (DLC1) to promote its tumor suppressor activity and inhibit the SRF coactivator MRTF-A. (PubMed, Neoplasia)
    We generated DLC1 binding peptides that dissociate the MRTF-A-FLNA complex and favor the novel DLC1-FLNA complex by preventing actin polymerization and FLNA phosphorylation at serine 2152. Since FLNA phosphorylation at serine 2152 was increased in mouse xenografts, reinforcing the DLC1-FLNA complex by targeting FLNA phosphorylation at serine 2152 represents a promising therapeutic approach for HCC treatment.
    Journal
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    MRTFA (Myocardin Related Transcription Factor A)
    7ms
    Myocardin-related transcription factor regulates actomyosin contractility and apical junction remodeling during vertebrate neural tube closure. (PubMed, Development)
    Our findings suggest a role of Mrtfa in the control of morphogenetic movements during neurulation. We propose that the regulation of actomyosin contractility is an essential cellular response to Mrtfa-dependent transcriptional activation.
    Journal
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    MRTFA (Myocardin Related Transcription Factor A)
    7ms
    Phosphoproteomics unveils the signaling dynamics in neuronal cells stimulated with insulin and insulin-like growth factors. (PubMed, bioRxiv)
    This study demonstrates that INS, IGF-1 and IGF-2 regulate Rho GTPase and MRTFA activation, thereby contributing to the control of actin cytoskeletal dynamics in neuronal cells. Given the role of INS and IGFs in neuronal survival and neurodegenerative conditions, elucidating the mechanisms is of critical importance, as it offers insights into disease pathogenesis and potential therapeutic targets.
    Journal
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    IGF1 (Insulin-like growth factor 1) • IGF2 (Insulin-like growth factor 2) • CDC42 (Cell Division Cycle 42) • MRTFA (Myocardin Related Transcription Factor A)
    9ms
    Multiplex imaging reveals novel patterns of MRTFA/B activation in the breast cancer microenvironment. (PubMed, J Transl Med)
    Our results provide unique insights into how MRTFA and MRTFB promote metastasis in human cancer, the differences of their expression patterns, and their immune suppressive function within the breast cancer TME. Our results will guide future studies on targeting MRTFA/B transcriptional activity and the resulting immune suppression in breast cancer.
    Journal • BRCA Biomarker
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    ER (Estrogen receptor) • HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1) • VSIR (V-Set Immunoregulatory Receptor) • MRTFA (Myocardin Related Transcription Factor A)
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    ER positive
    10ms
    The role of MICAL2 in cancer progression: mechanisms, challenges, and therapeutic potential. (PubMed, Hum Cell)
    Recent studies have shown that MICAL2 is highly expressed in tumors, accelerates tumor progression, and is a novel tumor-promoting factor. This article summarizes recent research findings to review the biological functions of MICAL2, the potential mechanisms related to cancer progression, and discusses the challenges and prospects in this area, providing a new theoretical basis for clinical molecular targeted therapy for cancer.
    Review • Journal
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    MICAL2 (Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2) • MRTFA (Myocardin Related Transcription Factor A)
    1year
    Comprehensive Genomic Profiling (CGP) of Acute Myeloid Leukemias with Foundation One Heme Identifies Actionable Genomic Alterations and Biomarkers (ASH 2024)
    Current best practices for the diagnosis, classification, prognostication, and treatment of AML call for the assessment of the presence and absence of numerous genomic alterations. Therefore, in contrast to single-gene or small-panel molecular testing, the F1H platform can simplify such assessment via a CGP approach.
    IO biomarker
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    TP53 (Tumor protein P53) • FLT3 (Fms-related tyrosine kinase 3) • ABL1 (ABL proto-oncogene 1) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • BCL2 (B-cell CLL/lymphoma 2) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • NPM1 (Nucleophosmin 1) • RUNX1 (RUNX Family Transcription Factor 1) • SF3B1 (Splicing Factor 3b Subunit 1) • ASXL1 (ASXL Transcriptional Regulator 1) • KMT2A (Lysine Methyltransferase 2A) • SRSF2 (Serine and arginine rich splicing factor 2) • RUNX1T1 (RUNX1 Partner Transcriptional Co-Repressor 1) • BCOR (BCL6 Corepressor) • NUP98 (Nucleoporin 98 And 96 Precursor 2) • U2AF1 (U2 Small Nuclear RNA Auxiliary Factor 1) • CEBPA (CCAAT Enhancer Binding Protein Alpha) • STAG2 (Stromal Antigen 2) • NUP214 (Nucleoporin 214) • MLLT3 (MLLT3 Super Elongation Complex Subunit) • MRTFA (Myocardin Related Transcription Factor A) • RBM15 (RNA Binding Motif Protein 15)
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    TP53 mutation • NPM1 mutation • KMT2A rearrangement • MLL rearrangement • U2AF1 mutation • CEBPA mutation • MLL mutation • NPM1 W288
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    FoundationOne® Heme CDx
    1year
    Identification of the MRTFA/SRF pathway as a critical regulator of quiescence in cancer. (PubMed, bioRxiv)
    Quiescence is a critical driver of chemoresistance. The MRFT-SRF pathway regulates cancer cell quiescence and inhibiting the MRTF-SRF pathway can prevent the outgrowth of quiescent cancer cells and improve cancer outcomes.
    Journal
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    MRTFA (Myocardin Related Transcription Factor A)
    over1year
    Liver fibrosis among infants with t(1;22)(p13;q13) acute megakaryoblastic leukemia: a case report and literature review. (PubMed, Front Oncol)
    Careful monitoring of liver functions and reduced-intensity chemotherapy are recommended for this very young patient population. Nonetheless, long-term survival can be achieved with aggressive supportive care and treatment.
    Review • Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • MRTFA (Myocardin Related Transcription Factor A) • RBM15 (RNA Binding Motif Protein 15)
    over1year
    Identification of novel inhibitors of the transcriptional coactivator MRTF-A for HCC therapy. (PubMed, Mol Ther Oncol)
    Both compounds were capable of inhibiting cell proliferation and inducing senescence in HCC cells with improved efficacy compared to NS8593. These inhibitors represent valuable tools for understanding the molecular basis of drug development targeting TRPM7 and MRTFs.
    Journal
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    RHOA (Ras homolog family member A) • TGFB1 (Transforming Growth Factor Beta 1) • MRTFA (Myocardin Related Transcription Factor A)