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    GENE:

    MRPL17 (Mitochondrial Ribosomal Protein L17)

    i
    Other names: MRPL17, Mitochondrial Ribosomal Protein L17, MRP-L26, RPML26, Mitochondrial Large Ribosomal Subunit Protein BL17m, 39S Ribosomal Protein L17, Mitochondrial, LYST-Interacting Protein 2, MRP-L17, L17mt, LIP2, LYST-Interacting Protein LIP2, RPL17L
    Associations

    News

    Trials
    2ms
    MRPL17 is a critical regulator of mitochondrial function and a novel therapeutic target in non-small cell lung cancer. (PubMed, Cell Death Dis)
    In vivo, MRPL17 silencing suppressed NSCLC xenograft growth in nude mice, a phenomenon associated with reduced COX8A levels, mitochondrial dysfunction, heightened oxidative stress, and increased apoptosis. Thus, MRPL17 is an important pro-cancerous target in NSCLC, driving malignant progression through the regulation of mitochondrial function and cellular redox balance, with COX8A identified as a key mediator.
    Journal
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    MRPL17 (Mitochondrial Ribosomal Protein L17)
    1year
    Targeting liver cancer stem cells: the prognostic significance of MRPL17 in immunotherapy response. (PubMed, Front Immunol)
    Cancer stem cells are pivotal in the mechanisms of immune evasion within the tumor microenvironment and have a substantial impact on treatment results. This study experimentally validated MRPL17 as a promising prognostic biomarker, emphasizing the need to target liver cancer stem cells to improve patient prognosis and enhance treatment effectiveness.
    Journal • IO biomarker
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    AFP (Alpha-fetoprotein) • MRPL17 (Mitochondrial Ribosomal Protein L17)
    over2years
    The role of the mitochondrial ribosomal protein family in detecting hepatocellular carcinoma and predicting prognosis, immune features, and drug sensitivity. (PubMed, Clin Transl Oncol)
    We identified 14 MRP genes as HCC diagnostic markers. We investigated FRG and m6A modification-related gene expression profiles and immune features in patients with HCC, and developed and validated a model incorporating MRP and FRG expression that accurately and reliably predicts HCC prognosis and may predict disease progression and treatment response.
    Journal
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    SLC1A5 (Solute Carrier Family 1 Member 5) • ABCC3 (ATP Binding Cassette Subfamily C Member 3) • MRPL16 (Mitochondrial Ribosomal Protein L16) • MRPL17 (Mitochondrial Ribosomal Protein L17) • MRPL47 (Mitochondrial Ribosomal Protein L47) • SLC5A1 (Solute Carrier Family 5 Member 1)