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    GENE:

    MND1 (Meiotic Nuclear Divisions 1)

    i
    Other names: MND1, Meiotic Nuclear Divisions 1, GAJ, Meiotic Nuclear Division Protein 1 Homolog, Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae), Meiotic Nuclear Divisions 1 Homolog, Homolog Of Yeast MND1
    Associations

    News

    Trials
    10ms
    MND1 Promotes the Proliferation of Prostate Cancer Cell via the CCNB1/p53 Signaling Pathway. (PubMed, Curr Cancer Drug Targets)
    MND1 promotes prostate cancer progression by facilitating the G0/G1 to S phase transition via the CCNB1/p53 pathway, making it a promising prognostic marker and potential therapeutic target.
    Journal
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    CCNB1 (Cyclin B1) • MND1 (Meiotic Nuclear Divisions 1)
    over1year
    Integrated pan-cancer analysis and experimental verification of the roles of meiotic nuclear divisions 1 in breast cancer. (PubMed, Biochem Biophys Res Commun)
    MND1 emerges as a promising biomarker for diagnostic and therapeutic targeting in various cancers, including BRCA. The abnormal up-regulation and activation of MND1 are linked to carcinogenesis and poor prognosis among BRCA patients, which may be attributed to its involvement in HR-dependent ALT, warranting further scrutiny.
    Journal • BRCA Biomarker • Pan tumor
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    BRCA (Breast cancer early onset) • MND1 (Meiotic Nuclear Divisions 1)
    over1year
    Integrative Pan-Cancer Analysis Reveals the Oncogenic Role of MND1 and Validation of MND1's Role in Breast Cancer. (PubMed, J Inflamm Res)
    MND1 is an oncogene and may serve as a biomarker for cancer prognosis and immunotherapy. Targeting MND1 may be a potential tumor treatment strategy.
    Journal • BRCA Biomarker • PD(L)-1 Biomarker • IO biomarker • Pan tumor
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • CDK4 (Cyclin-dependent kinase 4) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • CDK6 (Cyclin-dependent kinase 6) • CCND3 (Cyclin D3) • FOXP3 (Forkhead Box P3) • MND1 (Meiotic Nuclear Divisions 1)
    over2years
    FOXA1/MND1/TKT axis regulates gastric cancer progression and oxaliplatin sensitivity via PI3K/AKT signaling pathway. (PubMed, Cancer Cell Int)
    Our results confirm that FOXA1 inhibits the expression of MND1, which can directly bind to TKT to promote GC progression and reduce oxaliplatin sensitivity through the PI3K/AKT signaling pathway.
    Journal
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    FOXA1 (Forkhead Box A1) • MND1 (Meiotic Nuclear Divisions 1)
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    oxaliplatin