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    BIOMARKER:

    MMP2 overexpression

    i
    Other names: MMP2, CLG4, CLG4A, TBE-1, Matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
    Entrez ID:
    4313
    Related biomarkers:
    Mutation
    Others
    over1year
    LRRC45 promotes lung cancer proliferation and progression by enhancing c-MYC, Slug, MMP2, and MMP9 expression. (PubMed, Adv Med Sci)
    LRRC45 could promote the proliferative, migrative, and invasive capacities of lung cancer cells by increasing c-MYC, Slug, MMP2, and MMP9 expression, indicating the therapeutic implications and potential significance of these pathways in lung cancer.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • SNAI2 (Snail Family Transcriptional Repressor 2)
    |
    MYC overexpression • MYC expression • MMP2 overexpression
    almost2years
    miRNA-383-5p Regulated Migration and Invasion of Tumor Cells by Inhibiting NCKAP1 Expression in Gastric Cancer. (PubMed, Biochem Genet)
    The overexpression of NCKAP1 can increase the expression level and activity of MMP2, while the overexpression of miR383-5p can inhibit the increase of MMP2 expression level and activity in GC cells induced by NCKAP1 overexpression. NCKAP1 is a target gene of miR383-5p, and miR383-5p could be a valuable therapeutic target for stomach adenocarcinoma.
    Journal • Tumor cell
    |
    MMP2 (Matrix metallopeptidase 2) • MIR383 (MicroRNA 383)
    |
    MMP2 overexpression
    almost2years
    Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer. (PubMed, Open Med (Wars))
    Overall, this study revealed that circ_0051428 executes a tumor-promoting function in CC pathogenesis by modulating the miR-885-3p/MMP2 axis. Our findings provide a novel approach for CC treatment.
    Journal
    |
    MMP2 (Matrix metallopeptidase 2) • MIR885 (MicroRNA 885)
    |
    MMP2 overexpression
    almost2years
    The effects of thymidylate synthase 3'UTR genotype on methylation of tumor-specific genes promoter in 22 colorectal cancer patients from southern Iran. (PubMed, Mol Biol Res Commun)
    Moreover, promoter methylation status was not dependent on DNMTs gene expression. Large sample size studies may contribute to validate these findings.
    Journal
    |
    MLH1 (MutL homolog 1) • MSH2 (MutS Homolog 2) • CDH1 (Cadherin 1) • TYMS (Thymidylate Synthetase) • MMP2 (Matrix metallopeptidase 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A)
    |
    MMP2 overexpression
    2years
    Biosynthesized tumor acidity and MMP dual-responsive plant toxin gelonin for robust cancer therapy. (PubMed, Biomater Sci)
    Intriguingly, with enhanced stability and pH/MMP dual responsiveness, TPpG notably inhibited subcutaneous HT1080 xenograft growth in mice and no noticeable off-target side effect was observed. This ingeniously designed strategy aims at providing new perspectives for the development of a smart platform that can intelligently respond to a tumor microenvironment for efficient protein delivery.
    Journal
    |
    MMP2 (Matrix metallopeptidase 2)
    |
    MMP2 overexpression