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    BIOMARKER:

    MMP11 overexpression

    i
    Other names: Matrix Metallopeptidase 11, Stromelysin-3, STMY3, SL-3, ST3, Matrix Metalloproteinase 11 (Stromelysin 3), Matrix Metallopeptidase 11 (Stromelysin 3), Matrix Metalloproteinase-11, Stromelysin III, Stromelysin 3, MMP-11, MMP11
    Entrez ID:
    4320
    over1year
    linc00511 Knockdown Inhibits Lung Cancer Progression by Regulating miR-16-5p/MMP11. (PubMed, Crit Rev Eukaryot Gene Expr)
    Also, rescue experiments displayed that miR-16-5p inhibition or MMP11 overexpressing offset the suppressive impacts of linc00511 silencing on LC progression. To sum up, our findings indicated that linc00511 performed a crucial role in facilitating LC progression, and mechanistic studies demonstrated that linc00511 aggravated LC progression via targeting the miR-16-5p/MMP11 axis.
    Journal
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    MIR16 (MicroRNA 16) • MMP11 (Matrix Metallopeptidase 11)
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    MMP11 overexpression
    3years
    Matrix metalloproteinase 11 (MMP11) in macrophages promotes the migration of HER2-positive breast cancer cells and monocyte recruitment through CCL2-CCR2 signaling. (PubMed, Lab Invest)
    We also found that MMP11 expression in macrophages was stimulated by MMP11-overepressing HER2+ breast cancer cells. Collectively, our findings provide evidence that MMP11 in macrophages may play a pro-tumoral role in HER2+ breast cancer through interaction with cancer cells, monocytes, and endothelial cells.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • CCL2 (Chemokine (C-C motif) ligand 2) • MMP9 (Matrix metallopeptidase 9) • MMP11 (Matrix Metallopeptidase 11)
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    HER-2 positive • HER-2 overexpression • MMP11 overexpression
    3years
    CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation. (PubMed, J Cardiothorac Surg)
    CircMMP11 is overexpressed in NSCLC and predicts poor survival. In addition, circMMP11 may downregulate miR-143 through methylation to suppress cell proliferation.
    Journal
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    MIR143 (MicroRNA 143) • MMP11 (Matrix Metallopeptidase 11)
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    MMP11 overexpression