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    GENE:

    MMP1 (Matrix metallopeptidase 1)

    i
    Other names: MMP1, Matrix Metallopeptidase 1, Interstitial Collagenase, Fibroblast Collagenase, CLG, Matrix Metalloproteinase 1 (Interstitial Collagenase), Matrix Metallopeptidase 1 (Interstitial Collagenase), Matrix Metalloproteinase 1, Matrix Metalloproteinase-1, Matrix Metalloprotease 1, MMP-1, CLGN
    4d
    Bioinformatic Analysis of Contrasting Expression Patterns and Molecular Interactions of TIMPs in Breast Cancer: Implications for Tumor Progression and Survival. (PubMed, Pathophysiology)
    TIMPs display contrasting expression profiles and distinct pathway associations in breast cancer. TIMP1 emerges as the only consistently overexpressed inhibitor, while TIMP4 appears as a promising prognostic marker with unique MMP correlations that may influence tumor behaviors.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MMP2 (Matrix metallopeptidase 2) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • MMP9 (Matrix metallopeptidase 9) • MMP1 (Matrix metallopeptidase 1) • ADAM10 (ADAM Metallopeptidase Domain 10) • ADAM12 (ADAM Metallopeptidase Domain 12) • ADAM15 (ADAM Metallopeptidase Domain 15) • MMP14 (Matrix Metallopeptidase 14) • TIMP3 (TIMP Metallopeptidase Inhibitor 3)
    4d
    Trace Detection of Multiple Macromolecular Biomarkers in Saliva by Enzymatic Responsive Serial-Nanofluids Strategy. (PubMed, Adv Mater)
    Furthermore, the clinical trial indicated that our nanosensor could noninvasively, conveniently, and effectively distinguish healthy individuals from oral cancer patients, and those with lymph node metastasis. This strategy offers a robust framework for multi-marker detection in clinical diagnostics, facilitating high-frequency and large-scale cancer screening through saliva test.
    Journal
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    MMP1 (Matrix metallopeptidase 1) • MMP3 (Matrix metallopeptidase 3)
    11d
    Kaempferol Inhibits MMP-1-Mediated Migration and Invasion in Gemcitabine-Resistant Pancreatic Cancer Cells. (PubMed, Nutrients)
    Furthermore, kaempferol treatment reduced phosphorylated Akt expression and NF-κB p65 activity. These findings indicate that kaempferol suppresses the migratory and invasive abilities of PaCa cells by downregulating MMP-1 through negative regulation of the Akt and NF-κB signaling cascades, while kaempferol holds promise as a treatment strategy for GEM-R PaCa.
    Journal
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    MMP1 (Matrix metallopeptidase 1) • RELA (RELA Proto-Oncogene)
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    gemcitabine
    19d
    Inflammatory profile associated with hyperglycemia in children with type 1 diabetes. (PubMed, J Diabetes Complications)
    A broad range of inflammatory mediators are correlated with HbA1c in children with T1D. These inflammatory changes precede development of T1D complications, suggesting that possible pathophysiologic involvement should be investigated.
    Journal
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    IFNG (Interferon, gamma) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL2 (Interleukin 2) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • MMP2 (Matrix metallopeptidase 2) • CCL2 (Chemokine (C-C motif) ligand 2) • IL18 (Interleukin 18) • CCL8 (C-C Motif Chemokine Ligand 8) • IL17A (Interleukin 17A) • IL23A (Interleukin 23 Subunit Alpha) • CCL27 (C-C Motif Chemokine Ligand 27) • CXCL5 (Chemokine (C-X-C motif) ligand 5) • IL13 (Interleukin 13) • IL21 (Interleukin 21) • IL4 (Interleukin 4) • MMP1 (Matrix metallopeptidase 1) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • IL33 (Interleukin 33) • LIF (LIF Interleukin 6 Family Cytokine)
    19d
    Inhibition of Nuclear factor kappa B ameliorates bone destruction and osteoclastogenesis in collagen-induced arthritis mice. (PubMed, Afr Health Sci)
    NF-ϰB inhibitor treatment significantly decreased the above mRNA levels both in serum and joint tissues. NF-ϰB pathway inhibition can ameliorate bone destruction in the foot joints of CIA mice, which may be related to the reduction of inflammatory bone destruction and osteoclastogenesis.
    Preclinical • Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • MMP9 (Matrix metallopeptidase 9) • CTSK (Cathepsin K) • IL1B (Interleukin 1, beta) • MMP1 (Matrix metallopeptidase 1)
    23d
    Design, synthesis, and mechanism of anti-cancer activity of novel spiro tetramic acids. (PubMed, Bioorg Med Chem Lett)
    8d also induced cell apoptosis through the mitochondrial pathways, as evidenced by alterations in the expressions of pertinent proteins, including Bcl-2 and Bax. These results indicated that the novel spirotetramine derivative 8d is a potential anti-cancer candidate drug and provides a new structural basis for the development of anti-cancer drugs.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • PLK1 (Polo Like Kinase 1) • BAX (BCL2-associated X protein) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MMP1 (Matrix metallopeptidase 1) • CCNB1 (Cyclin B1) • MMP7 (Matrix metallopeptidase 7)
    27d
    Sitagliptin Potentiates the Anticancer Activity of Doxorubicin Through ROS-Driven Apoptosis and MMP/TIMP Regulation in HeLa Cells. (PubMed, Pharmaceutics)
    The combination exhibits a clear synergistic effect and demonstrates strong potential as a supportive therapeutic strategy. These findings warrant further in vivo and clinical-level investigations to evaluate the translational applicability of sitagliptin in cervical cancer therapy.
    Journal
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    AKT1 (V-akt murine thymoma viral oncogene homolog 1) • MAPK1 (Mitogen-activated protein kinase 1) • MMP2 (Matrix metallopeptidase 2) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • CASP8 (Caspase 8) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • CASP9 (Caspase 9) • MMP1 (Matrix metallopeptidase 1) • ANXA5 (Annexin A5)
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    doxorubicin hydrochloride
    27d
    Further Evidence for the Immunosuppressive Activity of Transmembrane Envelope Protein p15E of Porcine Endogenous Retrovirus. (PubMed, Int J Mol Sci)
    It also contributes to the understanding of the immunosuppressive properties of pathogenic retroviruses. Furthermore, expressing the immunosuppressive p15E of PERV on the surface of a pig xenotransplant may reduce the need for pharmaceutical immunosuppressants.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • IL10 (Interleukin 10) • IFNA1 (Interferon Alpha 1) • IL1B (Interleukin 1, beta) • MMP1 (Matrix metallopeptidase 1)
    27d
    Seed Oil of Lycium barbarum L. from Qaidam Basin Prevents and Treats UV-Induced Photodamage in BABL/c Mice Skin by Modulating Skin Microbiome and Amino Acid Metabolism. (PubMed, Int J Mol Sci)
    Notably, Firmicutes_A and Kineothrix, along with cysteine, cystine, glycine, arginine, proline, and choline, were identified as key microbial species and metabolites responsive to QLBSO's prophylactic and therapeutic effects. In conclusion, QLBSO likely protects against UV-induced skin photodamage by modulating the skin microbiota and amino acid metabolism, providing a scientific foundation for its potential use in skin health protection.
    Preclinical • Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • MMP1 (Matrix metallopeptidase 1) • CAT (Catalase) • MMP3 (Matrix metallopeptidase 3)
    27d
    Plasma Levels of Aromatase, Cathepsin S and Matrix Metalloproteinase 1 in Renal Cell Carcinomas: Implications for Tumor Progression and Diagnostic Value. (PubMed, Cancers (Basel))
    The biosensors used in the study can simultaneously determine ARO, CTSS, and MMP-1. The results obtained suggest the potential importance of these proteins in the development of ccRCC, and our work proposes a new diagnostic technique that may aid in the diagnosis of ccRCC.
    Journal
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    CTSS (Cathepsin S) • MMP1 (Matrix metallopeptidase 1)
    27d
    Dual-jet transition cold atmospheric plasma suppresses colon cancer stem cells via matrix metalloproteinase regulation. (PubMed, Cancer Treat Res Commun)
    Plasma diagnostics confirmed efficient energy utilization (<1 W) and high generation of reactive oxygen and nitrogen species (RONS), suggesting a RONS-mediated mechanism of action. These results demonstrate that DJTCAP selectively suppressesMMP expression and reduces CCSC viability, highlighting its potential as a safe, energy-efficient, and targeted therapy for metastatic and treatment-resistant colorectal cancer.
    Journal
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    MMP1 (Matrix metallopeptidase 1)