News - MMP1 overexpression

9ms

Elevated MMP1 Expression in Carcinoma-Associated Fibroblasts of Breast Cancer Contributes to Tumor Progression and Unfavorable Prognosis. (PubMed, Ann Clin Lab Sci)

The results indicated that MMP1 expression in CAFs may participate in the malignant phenotype and unfavorable prognosis of breast cancer.

9 months ago

Journal

MMP1 (Matrix metallopeptidase 1)

MMP1 overexpression

docetaxel

2years

MMP1 Overexpression Promotes Cancer Progression and Associates with Poor Outcome in Head and Neck Carcinoma. (PubMed, Comput Math Methods Med)

GSEA, GO, and KEGG analyses showed that MMP1 expression was significantly related to cancer-related pathways and cancer-related functions. Together, our results demonstrated MMP1 serves as a novel prognostic biomarker and putative oncogene in HNSCC.

2 years ago

Journal

MMP1 (Matrix metallopeptidase 1)

MMP1 overexpression

over3years

Overexpression of HOXA10 promotes the growth and metastasis of nasopharyngeal carcinoma. (PubMed, Exp Biol Med (Maywood))

Moreover, MMP1 overexpression facilitates nasopharyngeal carcinoma cell migration and invasion and contributes to cancer metastasis and progression. We thus concluded that HOXA10 overexpression promotes the growth and metastasis of nasopharyngeal carcinoma by transcriptionally activating various oncogenic pathways.

over 3 years ago

Journal

MMP1 (Matrix metallopeptidase 1) • SKP2 (S-phase kinase-associated protein 2)

MMP1 overexpression

over3years

Inhibitor of DNA Binding 2 (ID2): A Novel Marker for Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma. (PubMed, Ann Surg Oncol)

In the invasion and LNM of HNSCC, ID2 plays an important role by modulating MMP1 expression, suggesting ID2-MMP1 axis to be a novel alternative therapeutic target for invasion and LNM of HNSCC.

over 3 years ago

Journal

MMP1 (Matrix metallopeptidase 1)

MMP1 overexpression

almost4years

MMP1 drives tumor progression in large cell carcinoma of the lung through fibroblast senescence. (PubMed, Cancer Lett)

Furthermore, we implicate PAR-1 and oxidative stress in MMP1/TGF-β1-induced TAF senescence. Our results establish an entirely new role for MMP1 in cancer, and support a novel therapeutic strategy in LCC based on targeting senescent TAFs.

almost 4 years ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • MMP1 (Matrix metallopeptidase 1)

MMP1 overexpression