our Premium Content: News alerts, weekly reports and conference planners

GENE:

MME (Membrane Metalloendopeptidase)

News alerts, weekly reports and conference planners

Molecular characteristics and Helicobacter pylori infection rates in patients with gastric cancer in Western Poland: a comparative analysis of gastrectomy specimens across two decades. (PubMed, Front Oncol)

Despite advancements in H. pylori research and technology over 20 years, no improvement was observed in H. pylori-positive tumor rates or early gastric cancer detection in Western Poland. Although molecular characteristics remained largely unchanged, the increased proliferation index in recently diagnosed cancers merits further study.

4 days ago

Journal • IO biomarker

TP53 (Tumor protein P53) • MSI (Microsatellite instability) • BCL2 (B-cell CLL/lymphoma 2) • MSH2 (MutS Homolog 2) • PMS2 (PMS1 protein homolog 2) • CDH1 (Cadherin 1) • MME (Membrane Metalloendopeptidase) • CD31 (Platelet and endothelial cell adhesion molecule 1) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)

Measurable Residual Disease Assessment in B-Lymphoblastic Leukemia Using 5- and 10-Color Flow Cytometry: An Institutional Experience. (PubMed, Cureus)

In this cohort, 5‑color flow cytometry provided practical MRD assessment in B‑ALL, whereas 10‑color flow cytometry offered greater immunophenotypic detail and improved recognition of low‑level residual disease. These findings support the routine use of flow cytometry‑based MRD evaluation alongside morphology for post‑induction response assessment and risk‑adapted management in B‑ALL.

5 days ago

Journal

CD34 (CD34 molecule) • MME (Membrane Metalloendopeptidase) • CD58 (CD58 Molecule)

Three Years of Idiopathic Chylous Ascites: Splenic Marginal Zone Lymphoma Behind the Mask. (PubMed, Cureus)

This case illustrates that SMZL, although rare, should be included in the differential diagnosis of persistent chylous ascites. A comprehensive diagnostic approach combining imaging, bone marrow biopsy, and flow cytometry is essential to establish a timely diagnosis and guide appropriate management, especially in elderly patients.

7 days ago

Journal

CD5 (CD5 Molecule) • MME (Membrane Metalloendopeptidase)

Prognostic significance of Ki-67 in grade 3A follicular lymphoma and development of a novel PFS nomogram. (PubMed, Ann Hematol)

Grade 3A FL is characterized by marked clinical and biological heterogeneity. Our findings indicate that Ki-67 expression serves as a valuable prognostic marker that can inform therapeutic decision-making in patients with grade 3A FL. The proposed model integrating Ki-67 and clinical variables enhances PFS prediction and supports individualized treatment strategies for these patients.

8 days ago

Retrospective data • Journal

B2M (Beta-2-microglobulin) • CD5 (CD5 Molecule) • IRF4 (Interferon regulatory factor 4) • MME (Membrane Metalloendopeptidase)

Rituxan (rituximab)

ELOC-mutated Renal Cell Carcinoma: Clinicopathologic, Immunohistochemical, and Molecular Genetic Analysis of 35 Cases. (PubMed, Mod Pathol)

All patients with follow-up data were alive without evidence of disease progression. Our findings expand the clinical, histologic, immunohistochemical, and molecular spectrum of ELOC-mutated RCC and further support its classification as a distinct renal neoplasm.

9 days ago

Journal

KMT2C (Lysine Methyltransferase 2C) • CA9 (Carbonic anhydrase 9) • MME (Membrane Metalloendopeptidase) • GPNMB (Glycoprotein Nmb) • CDH23 (Cadherin Related 23)

10d

Renal Adenosarcoma Mimicking a Malignant Pelvocalyceal Tumor: An Interesting Imaging Case. (PubMed, Diagnostics (Basel))

These findings led to the diagnosis of primary renal adenosarcoma. This case highlights the diagnostic challenge of distinguishing this rare tumor from more common renal malignancies and underscores the importance of imaging-pathologic correlation.

10 days ago

Journal

PGR (Progesterone receptor) • BCOR (BCL6 Corepressor) • MME (Membrane Metalloendopeptidase) • CD99 (CD99 Molecule) • SS18 (SS18 Subunit Of BAF Chromatin Remodeling Complex)

11d

Testicular microcystic stromal tumor: a case report with MRI findings and literature review. (PubMed, Am J Transl Res)

This represents the first reported case of testicular MST with MRI findings, and its distinctive imaging features correlate with the tumor's unique histological structure. In this study, we comprehensively analyzed the clinical, radiological, histological, and immunohistochemical characteristics of this case and compared them with previously documented features in the literature, aiming to enhance the understanding of this rare entity and facilitate accurate diagnosis.

11 days ago

Journal

CCND1 (Cyclin D1) • WT1 (WT1 Transcription Factor) • NCAM1 (Neural cell adhesion molecule 1) • VIM (Vimentin) • MME (Membrane Metalloendopeptidase)

15d

Follicular Lymphoma with Signet Ring Cell Morphology: Clinicopathologic Analysis of 31 Cases. (PubMed, Hum Pathol)

We show that SR cells can be numerous in FL, but otherwise these cases resemble classic FL. We also provide results of next generation sequencing data on 4 cases which heretofore has not been reported.

15 days ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • BCL6 (B-cell CLL/lymphoma 6) • KMT2D (Lysine Methyltransferase 2D) • TNFRSF14 (TNF Receptor Superfamily Member 14) • MME (Membrane Metalloendopeptidase)

16d

Nonmyeloablative Allogeneic Stem Cell Transplantation With Postcyclophosphamide in a Case of Acute Lymphoblastic Leukemia Complicated by Ventricular Septal Defect. (PubMed, Transplant Proc)

In this case of ALL with VSD, the VSD hole diameter continued to enlarge during chemotherapy; however, after pre-transplant conditioning with PTCy, the diameter began to decrease around one year post-transplant, though it did not return to its original size. While careful monitoring is needed for right heart failure due to VSD enlargement, pre-transplant conditioning with PTCy was considered a feasible option for hematologic malignancies complicated by VSD.

16 days ago

Journal

CD34 (CD34 molecule) • MME (Membrane Metalloendopeptidase)

LDH elevation

cyclophosphamide

17d

Ultra-late triple metastasis to the breast, lung, and brain 25 years after nephrectomy for clear cell renal cell carcinoma: a case report and literature review. (PubMed, Front Oncol)

It underscores the necessity of lifelong follow-up for ccRCC survivors and demonstrates the integral role of imaging and pathological confirmation in guiding clinical diagnosis. Furthermore, the remarkable 25-year latency period challenges existing surveillance paradigms and provides a compelling rationale for the use of combined immunotherapy and targeted agents in managing ultra-late, multi-metastatic recurrences.

17 days ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • PGR (Progesterone receptor) • CA9 (Carbonic anhydrase 9) • MME (Membrane Metalloendopeptidase) • PAX8 (Paired box 8)

18d

Clinicopathological and molecular features of acquired cystic disease-associated renal cell carcinoma (PubMed, Zhonghua Bing Li Xue Za Zhi)

ACD-RCC is a rare renal cell carcinoma that occurs in patients with end-stage renal disease and has unique morphological features. It is often associated with favorable prognosis and alterations in genes related to the MTOR/TSC pathway or chromatin modification.

18 days ago

Journal

ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • KIT (KIT proto-oncogene, receptor tyrosine kinase) • KMT2C (Lysine Methyltransferase 2C) • TSC2 (TSC complex subunit 2) • SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1) • SDHB (Succinate Dehydrogenase Complex Iron Sulfur Subunit B) • TSC1 (TSC complex subunit 1) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • TFE3 (Transcription Factor Binding To IGHM Enhancer 3) • MME (Membrane Metalloendopeptidase) • KMT2B (Lysine Methyltransferase 2B) • GATA3 (GATA binding protein 3) • PAX8 (Paired box 8) • TFEB (Transcription Factor EB 2)

TP53 mutation