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    BIOMARKER:

    MLPH overexpression

    i
    Other names: MLPH, Melanophilin, Exophilin-3, Slp Homolog Lacking C2 Domains A, Synaptotagmin-Like Protein 2a, L(1)-3Rk, SLAC2-A, Slac-2a, SlaC2-A, SLAC2A, L1Rk3, Ln
    Entrez ID:
    79083
    over1year
    MLPH regulates EMT in pancreatic adenocarcinoma through the PI3K-AKT signaling pathway. (PubMed, J Cancer)
    LY294002 blocked the MLPH overexpression-mediated enhanced cell invasion and migration and inhibited EMT-associated marker expression...MLPH regulated EMT to mediate PAAD cell invasive migration through the PI3K-AKT pathway. The results indicated that MLPH is a possible target for blocking PAAD metastasis.
    Journal
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    MLPH (Melanophilin)
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    MLPH overexpression
    |
    LY294002
    4years
    Overexpression of MLPH in Rectal Cancer Patients Correlates with a Poorer Response to Preoperative Chemoradiotherapy and Reduced Patient Survival. (PubMed, Diagnostics (Basel))
    After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178-46.920; p = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762-17.931; p = 0.004). In conclusion, identifying MLPH expression could help to predict the response to chemoradiation and survival, and aid in personal therapeutic modification.
    Clinical • Journal
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    MLPH (Melanophilin)
    |
    MLPH overexpression