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    BIOMARKER:

    MLL-AFF4 fusion

    i
    Other names: AFF4, AF4/FMR2 Family Member 4, Major CDK9 Elongation Factor-Associated Protein, ALL1-Fused Gene From Chromosome 5q31 Protein, AF5Q31, MCEF, ALL1 Fused Gene From 5q31, AF4/FMR2 Family, Member 4, Protein AF-5q31, HTRX1, HTRX, MLL1A, Mixed Lineage Leukemia 1, Myeloid/Lymphoid Or Mixed-Lineage Leukemia Protein 1, CXXC7, MLL1, TRX1, Zinc Finger Protein HRX, Trithorax-Like Protein, ALL-1, Lysine (K)-Specific Methyltransferase 2A, CXXC-Type Zinc Finger Protein 7, Histone-Lysine N-Methyltransferase 2A,
    Entrez ID:
    27125
    Related biomarkers:
    Fusion
    Others
    Associations

    News

    Trials
    1year
    PI3K/ c-Myc/AFF4 axis promotes pancreatic tumorigenesis through fueling nucleotide metabolism. (PubMed, Int J Biol Sci)
    Finally, we obtained the positive correlation between c-Myc and AFF4 or AFF4 and HPRT1/IMPDH2 in clinical PDAC samples. Otherwise, we conducted data-mining and found that the expression levels of AFF4 and HPRT1/IMPDH2 are correlated with patients' prognosis, establishing AFF4 as a potential biomarker and therapeutic target for PDAC.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • AFF4 (AF4/FMR2 Family Member 4) • CDK9 (Cyclin Dependent Kinase 9) • HPRT1 (Hypoxanthine Phosphoribosyltransferase 1) • PAX2 (Paired Box 2)
    |
    MYC expression • MLL-AFF4 fusion