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GENE:

MIRLET7B (MicroRNA Let-7b)

News alerts, weekly reports and conference planners

Deer antler stem cell-derived exosomes: a regenerative medicine powerhouse from nature's own repair kit. (PubMed, Front Cell Dev Biol)

Moreover, this review reveals the challenges in the contemporary research that are of critical importance: optimization of large-scale production and purification of ASC-Exos to provide uniformity in the clinical use; full clarification of the molecular processes that underlie ASC-Exos-mediated effects (e.g., metabolic reprogramming control in tumors); and the absence of detailed preclinical and clinical data on the long-term safety and efficacy. Finally, the review would serve as a valuable resource to developing fundamental research in the field of ASC-Exos and increasing the pace of its clinical application, especially when used together in conjunction with more sophisticated methods of drug delivery and tissue regeneration, to achieve new prospects in the treatment of incurable diseases and repair tissue in regenerative medicine.

6 days ago

Review • Journal • PD(L)-1 Biomarker • IO biomarker

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • CD81 (CD81 Molecule) • MIRLET7B (MicroRNA Let-7b) • RUNX2 (RUNX Family Transcription Factor 2) • TSG101 (Tumor Susceptibility 101)

27d

Liquid Biopsy in Clear Cell Renal Cell Carcinoma: Diagnostic Potential of Urinary miRNAs. (PubMed, Cancers (Basel))

These findings support urinary miRNAs as promising, minimally invasive biomarkers for ccRCC diagnosis and postoperative monitoring.

27 days ago

Journal • Liquid biopsy

MIR16 (MicroRNA 16) • MIR210 (MicroRNA 210) • MIR15A (MicroRNA 15a) • MIR15B (MicroRNA 15b) • MIRLET7B (MicroRNA Let-7b)

29d

Multi-Omics and Functional Analyses Identify let-7b-3p as a Negative Regulator of EMT in Lung Adenocarcinoma. (PubMed, J Biochem Mol Toxicol)

Importantly, this study is the first to reveal the inhibitory role of let-7b-3p in LUAD through the HMGA2-LIN28A axis in regulating the Wnt/TGF-β signaling pathway and EMT. These findings highlight the originality of this work and underscore the potential clinical translational value of targeting let-7b-3p or the HMGA2-LIN28A axis as novel therapeutic strategies for LUAD.

29 days ago

Journal

TGFB1 (Transforming Growth Factor Beta 1) • HMGA2 (High mobility group AT-hook 2) • MIRLET7B (MicroRNA Let-7b)

Mechanism of Non-Small Cell Lung Cancer-Derived Extracellular Vesicle miRNA hsa-let-7b-5p Targeting AP1S1 to Regulate M2 Macrophage Polarization. (PubMed, Int J Genomics)

This study revealed the molecular mechanism by which hsa-let-7b-5p reshapes the immune microenvironment of NSCLC cells by targeting and inhibiting AP1S1 expression, thereby regulating the polarization of TAMs toward the M2 phenotype. Thus, the hsa-let-7b-5p/AP1S1 axis may serve as a potential therapeutic target for NSCLC immunotherapy, providing novel strategies for improving patient prognosis.

1 month ago

Journal • IO biomarker

MIRLET7B (MicroRNA Let-7b)

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

The role of microRNAs in gastritis, intestinal metaplasia, and gastric cancer: a narrative review. (PubMed, Transl Cancer Res)

Clinically, circulating miRNA panels (e.g., miR-4257, miR-6785-5p, and miR-187-5p) enhance early detection, while miR-125a-5p boosts the trastuzumab response via ERBB2 targeting...This review highlights miRNAs as pivotal regulators in gastric carcinogenesis and promising precision medicine tools. The study findings will promote the standardization of profiling methods and accelerate translational research, both of which are essential to the advancement of GC diagnostic and therapeutic strategies.

2 months ago

Review • Journal

HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • CDX2 (Caudal Type Homeobox 2) • FOXD1 (Forkhead Box D1) • MIR375 (MicroRNA 375) • MIR425 (MicroRNA 425) • MIR92A1 (MicroRNA 92a-1) • MIR125A (MicroRNA 125a) • MIR187 (MicroRNA 187) • MIRLET7B (MicroRNA Let-7b) • MIR6785 (MicroRNA 6785)

Herceptin (trastuzumab)

2ms

hsa-let-7b-5p-associated BUB1/TMPO-AS1 ceRNA axis identified as a potential biomarker in lung adenocarcinoma. (PubMed, Cell Div)

This study identifies the BUB1/E2F1/TMPO-AS1/hsa-let-7b-5p axis as a potential prognostic biomarker and therapeutic target in LUAD. Targeting hsa-let-7b-5p may modulate this network, offering opportunities for both diagnostic and prognostic interventions.

2 months ago

Journal

CD4 (CD4 Molecule) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • E2F1 (E2F transcription factor 1) • MIRLET7B (MicroRNA Let-7b) • TMPO-AS1 (TMPO Antisense RNA 1)

3ms

Integrative bioinformatic and clinical validation reveals dynamic regulation of circulating microRNAs before and after antiretroviral therapy in HIV-positive patients. (PubMed, Sci Rep)

Our study identifies key miRNAs as significant HIV-disease interactors through in silico prediction and cohort validation. Our findings lay the groundwork for future studies exploring the functional roles of these miRNAs and their potential as biomarkers of immune recovery or targets for therapeutic modulation in ART-treated populations.

3 months ago

Journal

MIR155 (MicroRNA 155) • MIR16 (MicroRNA 16) • MIRLET7B (MicroRNA Let-7b)

3ms

Extracellular microRNAs modulate human microglial function through TLR8. (PubMed, Front Immunol)

Extracellular delivery of miR-132-5p and miR-9-5p to co-cultures of iNeurons and iMGLs resulted in reduced neurite length. Our data establish that distinct CNS disease-associated miRNAs serve as signaling molecules for human microglia via TLR8, thereby controlling the diverse microglial functions and modulating the neuroinflammatory response.

3 months ago

Journal • IO biomarker

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TLR8 (Toll Like Receptor 8) • MIR132 (MicroRNA 132) • MIR340 (MicroRNA 340) • TLR7 (Toll Like Receptor 7) • MIR30E (MicroRNA 30e) • MIRLET7B (MicroRNA Let-7b)

3ms

MicroRNAs Let-7b-5p and miR-24-3p as Potential Therapeutic Agents Targeting Pancreatic Cancer Stem Cells. (PubMed, Int J Mol Sci)

Functionally, each miRNA reduced sphere formation, increased gemcitabine sensitivity, and suppressed tumorigenicity in vivo, highlighting their potential as therapeutic candidates. Restoring tumor-suppressive miRNA expression may offer a novel strategy to overcome chemoresistance and improve outcomes in pancreatic cancer.

3 months ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • CD44 (CD44 Molecule) • CD24 (CD24 Molecule) • TGFB1 (Transforming Growth Factor Beta 1) • MIRLET7B (MicroRNA Let-7b)

gemcitabine

3ms

Bioinformatics insights into TMPO-AS1-let-7b-5p-ESPL1/E2F8 regulatory axis in breast cancer. (PubMed, Front Cell Dev Biol)

Notably, the 3' untranslated region (3'UTR) of ESPL1 showed strong binding sites for hsa-let-7b-5p. We also identified Hesperidin as a high affinity ESPL1 binders, suggesting novel therapeutic candidates targeting this oncogenic network.

3 months ago

Journal

ER (Estrogen receptor) • PGR (Progesterone receptor) • E2F8 (E2F Transcription Factor 8) • MIRLET7B (MicroRNA Let-7b) • TMPO-AS1 (TMPO Antisense RNA 1)

ER negative

3ms

Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA. (PubMed, Front Oncol)

This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies. This research validates the diagnostic and prognostic utility of exosomal miRNA models in MM, emphasizing their discriminative and predictive capabilities.

3 months ago

Journal

MIR192 (MicroRNA 192) • MIR193B (MicroRNA 193b) • MIR10B (MicroRNA 10b) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIRLET7B (MicroRNA Let-7b)