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    GENE:

    MIR936 (MicroRNA 936)

    i
    Other names: MIR936, MicroRNA 936, Hsa-Mir-936, Hsa-MiR-936, MIRN936, MIMAT0004979, MI0005758, RF01002
    Associations

    News

    Trials
    4ms
    Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/β-catenin axis. (PubMed, Cell Mol Biol Lett)
    Overall, circSLC39A10 is an oncogenic circRNA with potential as a biomarker for PCa. The identified circSLC39A10/miR-936/PROX1/β-catenin axis shows promise as an innovative therapeutic target for PCa.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR936 (MicroRNA 936)
    over1year
    Low miR-936-mediated upregulation of Pim-3 drives sorafenib resistance in liver cancer through ferroptosis inhibition by activating the ANKRD18A/Src/NRF2 pathway. (PubMed, Front Oncol)
    Moreover, the elevated expression of Pim-3, resulting from the absence of miR-936 enhances sorafenib resistance in liver cancer by inhibiting cell ferroptosis. Pim-3 can be regarded as a target in the treatment of sorafenib-resistant liver cancer.
    Journal
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    HMOX1 (Heme Oxygenase 1) • GPX4 (Glutathione Peroxidase 4) • NQO1 (NAD(P)H dehydrogenase, quinone 1) • TFRC • SLC7A11 (Solute Carrier Family 7 Member 11) • DMRT1 (Doublesex And Mab-3 Related Transcription Factor 1) • MIR936 (MicroRNA 936) • PIM3 (Pim-3 Proto-Oncogene)
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    HMOX1 expression • SLC7A11 expression
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    sorafenib
    over1year
    Knockdown of circ_0076305 decreases the paclitaxel resistance of non-small cell lung cancer cells by regulating TMPRSS4 via miR-936. (PubMed, Toxicol Res (Camb))
    Circ_0076305 silencing increased the PTX sensitivity of xenograft tumors in vivo. Circ_0076305 silencing promoted PTX sensitivity by targeting miR-936/TMPRSS4 axis in NSCLC cells.
    Journal
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    PRSS3 (Serine Protease 3) • MIR936 (MicroRNA 936) • TMPRSS4 (Transmembrane Serine Protease 4)
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    paclitaxel
    almost2years
    CircZCCHC2 (hsa_circ_0000854) promotes hepatocellular carcinoma progression through modulating miR-936/BTBD7 axis and activating Rho/ROCK2 pathway. (PubMed, Noncoding RNA Res)
    Additionally, the suppressed Rho/ROCK2 pathway conferred by circZCCHC2 knockdown could be restored by inhibiting miR-936 expression. Collectively, our findings reveal that circZCCHC2 plays an oncogenic role of in HCC progression by modulating the miR-936/BTBD7/Rho/ROCK2 pathway.
    Journal
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    BTBD7 (BTB Domain Containing 7) • MIR936 (MicroRNA 936)
    almost3years
    Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells. (PubMed, Reprod Biol)
    MiR-936-mediated suppression of CUL4B hinders cell proliferation, migration, and invasion and accelerates apoptosis in vitro.. These data suggested that circ_0021573 might promote the malignant phenotypes of ovarian cancer cells by functioning as a ceRNA for miR-936 to induce CUL4B, which provided a promising target for the prevention and inhibition of ovarian cancer.
    Journal
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    CUL4B (Cullin 4B) • MIR936 (MicroRNA 936)