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    GENE:

    MIR708 (MicroRNA 708)

    i
    Other names: MIR708, MicroRNA 708, Hsa-MiR-708-3p, Hsa-MiR-708-5p, Hsa-Mir-708, MIRN708, Hsa-Mir-28-P3_pre, MIMAT0004926, MIMAT0004927, MI0005543, RF00917
    Associations

    News

    Trials
    17d
    Melanoma exosomal miR-708-5p promotes macrophage M2 polarization and cancer metastasis. (PubMed, Cell Death Dis)
    Interestingly, we found that cellular retention of miR-708-5p could inhibit the proliferation and promote the apoptosis of melanoma cells, suggesting the necessity for secretion of this microRNA. In summary, our findings provide novel insights into the mechanism of melanoma-derived miR-708-5p in facilitating the formation of an immunosuppressive tumor microenvironment and indicate the potential of miR-708-5p and FOXN3 as therapeutic targets for the treatment of melanoma.
    Journal
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    IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1) • MIR708 (MicroRNA 708)
    4ms
    Transposable Element-Derived miR-28-5p and miR-708-5p: Exploring Potential Roles in Lung Cancer. (PubMed, Noncoding RNA)
    Furthermore, we emphasize that miR-28 and miR-708 might contribute to lung cancer pathogenesis by targeting key tumor suppressor genes. Alterations in the methylation status of L2-miRNAs genomic loci might result in elevated levels of miRNAs and subsequent targeting of tumor suppressor genes with potential implications in lung cancer pathogenesis.
    Journal
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    TENM4 (Teneurin Transmembrane Protein 4) • MIR708 (MicroRNA 708)
    5ms
    miR-28-5p and miR-708-5p Share a Common Seed with Different Functions in Lung Cancer Patients. (PubMed, Int J Mol Sci)
    Pathway enrichment analysis indicated that these miRNAs regulate several cancer-associated pathways, including ECM-receptor interaction, adherens junctions, and Hippo signaling. Overall, our findings suggest that miR-708-5p may have a potential clinical application in lung cancer.
    Journal
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    MIR708 (MicroRNA 708)
    8ms
    miR-708-5p Attenuates Osteoarthritis Progression via Multi-Target Modulation of the NOX4/NF-κB Axis and Cartilage Homeostasis. (PubMed, Cartilage)
    NOX4 overexpression reversed the protective effects of miR-708-5p, confirming the functional significance of this regulatory axis.ConclusionmiR-708-5p is downregulated in OA and exerts chondroprotective effects. These findings suggest that restoring miR-708-5p expression may effectively suppress the NOX4/NF-κB axis and modulate chondrocyte inflammation, oxidative stress, apoptosis, and matrix degradation.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • IL6 (Interleukin 6) • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • SOX9 (SRY-Box Transcription Factor 9) • IL1B (Interleukin 1, beta) • NOX4 (NADPH Oxidase 4) • COL2A1 (Collagen Type II Alpha 1 Chain) • MIR708 (MicroRNA 708) • MMP3 (Matrix metallopeptidase 3)
    1year
    The crosstalk between lung adenocarcinoma cells and M2 macrophages promotes cancer cell development via the SFRS1/miR-708-5p/PD-L1 axis. (PubMed, Life Sci)
    We observed that exosomal miR-708-5p mediated the PTEN/AKT/mTOR pathway, diminished CD8 T cell activity and accelerated LUAD progression. The inhibition of specific exosomal miRNA secretion and anti-PD-L1 in the LUAD microenvironment may represent a promising avenue for LUAD immunotherapy.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • MIR708 (MicroRNA 708)
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    PD-L1 expression
    over1year
    Exosome-transported circ_0001955 as a potent driver of breast cancer by regulating the miR-708-5p/PGK1 axis. (PubMed, Thorac Cancer)
    Exosomal circ_0001955 excreted from breast cancer cells facilitated proliferation and glycolysis and enhanced the IC50 value of PTX in breast cancer cells by sponging miR-708-5p to upregulate PGK1.
    Journal
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    HK2 (Hexokinase 2) • MIR708 (MicroRNA 708) • PGK1 (Phosphoglycerate Kinase 1)
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    paclitaxel
    over1year
    The Association Between Anti-Neoplastic Effects of Curcumin and Urogenital Cancers: A Systematic Review. (PubMed, Biomed Res Int)
    Curcumin exerts its anticancer effects on urogenital neoplasms by upregulating tumor suppressor microRNAs (miR-143, miR-145, miR-Let-7, miR-101, miR-3127, miR-3178, miR-1275, miR-3198, miR-1908, miR-770, miR-1247, miR-411, miR-34a, miR-383, miR-708, miR-483, miR-199a, miR-335, miR-503, miR-10b, miR-551a, miR-9, miR-203, miR-7110, miR-29b, and miR-126) and downregulating oncogenic microRNAs (miR-21, miR-210, miR-382, miR-654, miR-494, miR-193b, miR-671, miR-222, miR-23b, miR-664, miR-183, miR-214, miR-320a, miR-23a, miR-30a, miR-320d, miR-1285, miR-32, miR-181a, miR-205, miR-216a, miR-1246, and miR-106b). Cell proliferation is inhibited, and cell apoptosis is induced by curcumin in different urogenital cancers through suppressing oncogenic microRNAs or provoking tumor suppressor microRNAs.
    Review • Journal
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    MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • MIR193B (MicroRNA 193b) • MIR1246 (MicroRNA 1246) • MIR126 (MicroRNA 126) • MIR143 (MicroRNA 143) • MIR199A (MicroRNA 199a) • MIR210 (MicroRNA 210) • MIR216A (MicroRNA 216a) • MIR23A (MicroRNA 23a) • MIR23b (MicroRNA 23b) • MIR320A (MicroRNA 320a) • MIR335 (MicroRNA 335) • MIR494 (MicroRNA 494) • MIR503 (MicroRNA 503) • MIR664A (MicroRNA 664a) • MIR106B (MicroRNA 106b) • MIR10B (MicroRNA 10b) • MIR1247 (MicroRNA 1247) • MIR127 (MicroRNA 127) • MIR145 (MicroRNA 145) • MIR181A1 (MicroRNA 181a-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR214 (MicroRNA 214) • MIR222 (MicroRNA 222) • MIR30A (MicroRNA 30a) • MIR3178 (MicroRNA 3178) • MIR383 (MicroRNA 383) • MIR483 (MicroRNA 483) • MIR671 (MicroRNA 671) • MIR708 (MicroRNA 708)
    over1year
    Circulating miRNA panels as a novel non-invasive diagnostic, prognostic, and potential predictive biomarkers in non-small cell lung cancer (NSCLC). (PubMed, Br J Cancer)
    Circulating miRNA signatures demonstrate diagnostic and prognostic value for NSCLC and may guide treatment decisions in clinical practice.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    MIR96 (MicroRNA 96) • MIR135B (MicroRNA 135b) • MIR31 (MicroRNA 31) • MIR760 (MicroRNA 760) • MIR183 (MicroRNA 183) • MIR205 (MicroRNA 205) • MIR708 (MicroRNA 708)
    over1year
    The lncRNA UCA1 Enhances Pancreatic Cancer EMT by Regulating miR-708-5p and miR-135b-5p: A Bioinformatics Approach. (PubMed, Iran J Public Health)
    Thus, it is reasonable to believe that this prognostic risk model helps predict PC metastasis. UCA1 is a new lncRNA linked with EMT in PC and contributes to a better knowledge of the regulatory mechanisms related to lncRNAs in PC.
    Journal
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    ITK (IL2 Inducible T Cell Kinase) • MIR135B (MicroRNA 135b) • MIR708 (MicroRNA 708)
    over1year
    MicroRNA Signatures Associated with Basal Cell Carcinoma Subtypes. (PubMed, JID Innov)
    Receiver operating characteristic analysis demonstrated excellent capacity of these miRs to discriminate between BCC and control skin (area under the curve, 0.94-0.98), whereas the capacity to discriminate between superficial and invasive subtypes was less robust (area under the curve, 0.7-0.8). Future prospective studies may determine the utility of these miRs as diagnostic biomarkers to guide biopsy and treatment of BCC.
    Journal
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    MIR16 (MicroRNA 16) • MIR145 (MicroRNA 145) • MIR181C (MicroRNA 181c) • MIR22 (MicroRNA 22) • MIR30C • MIR383 (MicroRNA 383) • MIR708 (MicroRNA 708)
    almost2years
    miRNA- and Cell Line-Specific Constraints on Precursor miRNA Processing of Stably Transfected Pancreatic Cancer and Other Mammalian Cells. (PubMed, Int J Mol Sci)
    Our findings on the structural and sequence differences between successful and non-successful vector designs could help to inform future chimeric miRNA design strategies and act as a guide to other researchers on the intricate processing dynamics that can impact vector efficiency. Our research confirms the potential of miRNA mimics to surmount some of these complexities.
    Preclinical • Journal
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    MIR708 (MicroRNA 708)
    almost2years
    Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors. (PubMed, Clin Exp Med)
    This article reviews the current understanding of the biological function and clinical significance of LOXL1-AS1 in human cancers. These findings suggest that LOXL1-AS1 may be both a reliable biomarker and a potential therapeutic target for cancers.
    Review • Journal
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    MIR21 (MicroRNA 21) • MIR324 (MicroRNA 324) • MIR143 (MicroRNA 143) • MIR122 (MicroRNA 122) • MIR374B (MicroRNA 374b) • MIR423 (MicroRNA 423) • MIR708 (MicroRNA 708) • MIR761 (MicroRNA 761)