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    GENE:

    MIR6785 (MicroRNA 6785)

    i
    Other names: MIR6785, MicroRNA 6785, Hsa-Mir-6785, MicroRNA Mir-6785, MIMAT0027471, MIMAT0027470, MI0022630
    Associations

    News

    Trials
    2ms
    The role of microRNAs in gastritis, intestinal metaplasia, and gastric cancer: a narrative review. (PubMed, Transl Cancer Res)
    Clinically, circulating miRNA panels (e.g., miR-4257, miR-6785-5p, and miR-187-5p) enhance early detection, while miR-125a-5p boosts the trastuzumab response via ERBB2 targeting...This review highlights miRNAs as pivotal regulators in gastric carcinogenesis and promising precision medicine tools. The study findings will promote the standardization of profiling methods and accelerate translational research, both of which are essential to the advancement of GC diagnostic and therapeutic strategies.
    Review • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • CDX2 (Caudal Type Homeobox 2) • FOXD1 (Forkhead Box D1) • MIR375 (MicroRNA 375) • MIR425 (MicroRNA 425) • MIR92A1 (MicroRNA 92a-1) • MIR125A (MicroRNA 125a) • MIR187 (MicroRNA 187) • MIRLET7B (MicroRNA Let-7b) • MIR6785 (MicroRNA 6785)
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    Herceptin (trastuzumab)
    almost2years
    LncRNA LUESCC promotes esophageal squamous cell carcinoma by targeting the miR-6785-5p/NRSN2 axis. (PubMed, Cell Mol Life Sci)
    Furthermore, ASO targeting LUESCC substantially suppressed ESCC both in vitro and in vivo. Collectively, these data demonstrate that LUESCC may exerts its oncogenic role by sponging miR-6785-5p to promote NRSN2 expression in ESCC, providing a potential diagnostic marker and therapeutic target for ESCC patients.
    Journal
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    MIR6785 (MicroRNA 6785)
    over2years
    MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment. (PubMed, Comput Biol Chem)
    Those 49 miRNAs regulate the expression of 122 genes in AD and 93 genes in BC, from which 26 genes are common genes for AD and BC involved in neuron differentiation and genesis, cell differentiation and migration, regulation of cell cycle, and cancer development. Additionally, the highly enriched pathway was associated with diabetic complications, pointing out possible interplay among molecules underlying BC, AD, and diabetes pathology.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • PTEN (Phosphatase and tensin homolog) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR17 (MicroRNA 17) • MIR124-3 (MicroRNA 124-3) • MIR6127 (MicroRNA 6127) • MIR6785 (MicroRNA 6785) • MIR6870 (MicroRNA 6870) • MIR8485 (MicroRNA 8485)