MIR671 (MicroRNA 671)

The Editor apologizes to the readership for any inconvenience caused. [Molecular Medicine Reports 20: 3149‑3159, 2019; DOI: 10.3892/mmr.2019.10563].

HOXB-AS1 could regulate miR-671-5p and SPTBN2 expression and participate in the functional activities of ovarian cancer cells. HOXB-AS1 repressed ferroptosis in a miR-671-5p/SPTBN2-dependent manner in epithelial ovarian cancer, thereby facilitating the progression of ovarian cancer, which might be a therapeutic target for treating ovarian cancer.

When loaded with penicillin, circAAGAB, or both, LTA-MSNs precisely targeted intratumoral S. mitis in ESCC patient-derived xenograft (PDX) models, demonstrating potent tumor-suppressive efficacy. Collectively, our findings reveal that intratumoral S. mitis critically drives ESCC tumorigenesis and represents a promising therapeutic target.

Circulating miRNAs, including hsa-miR-3619-3p, hsa-miR-1290, and hsa-miR-1185-2-3p, correlated with AFP levels and disease stage, underscoring their value as non-invasive biomarkers. These findings demonstrate that integrated analysis of tissue and serum miRNAs can identify clinically relevant biomarkers and potential therapeutic targets in HCC.

Additionally, the external validation datasets showed an AUC exceeding 95%, confirming the robustness and reliability of our findings. Furthermore, functional annotation analysis revealed the involvement of several miRNA-mediated pathways in the pathogenesis of CRC.

Furthermore, Reactome analysis revealed enrichment in the following processes 'Cell cycle, Mitotic' (R‑HAS‑69278), 'Apoptosis' (R‑HAS‑109581) and 'Immune system' (R‑HAS‑168256), suggesting that these miRNAs regulate genes involved in these pathways. These findings indicated that the altered expression of five specific microRNAs in radioresistant AML cells may be associated with radioresistant conditions through the modulation of mRNA expression.

This study identifies a hypoxia-driven feedforward loop wherein CAF-derived exosomal circSTAT3 promotes TNBC stemness and chemoresistance via miR-671-5p/NOTCH1 signaling. CircSTAT3 redefines stromal-tumor crosstalk as a circRNA-driven process and serves as both a circulating non-invasive biomarker and a promising therapeutic target to disrupt stromal-mediated resistance in aggressive TNBC.

These findings indicated that miR-29a and miR-29b are involved in imatinib resistance by downregulating NF1 expression and activating ERK1/2. Additionally, the miR-29a, miR-29b, and NF1/ERK axis may be potential targets for the treatment of imatinib-resistant CML.

By elucidating the multifaceted roles of miRNAs in H. pylori infection, this review provides invaluable insights into disease pathogenesis, diagnostics, and therapeutics, and the role of some nanoparticles in combating the H. pylori infection. Continued research efforts are imperative for translating these insights into clinical practice and addressing the global burden of H. pylori-related diseases.

The present work revealed the candidate ceRNA regulatory pathway by which PVT1-214 regulates SLC45A4 expression in GC cells, which is achieved through competitive binding to endogenous miR-671-5p. The results of this study can shed novel light on new molecular targets for treating GC.

In addition, miR-671-3p is expressed at high levels in circulating exosomes isolated from patients with LUAD. Our study suggests that exosome miR-671-3p is involved in the formation of premetastatic niche and may serve as a blood-based biomarker for LUAD metastasis.

PSMB2, a downstream target gene of miR-671-5p, could inhibit the protective effect of Sevo on H/R cardiomyocytes. Sevo postconditioning exerts a protective effect in H/R-induced cardiomyocyte injury, which may be achieved by interfering with LINC00339/miR-671-5p/PSMB2 expression.