MIR557 (MicroRNA 557)

Alterations in miRNA expression play an important role in the pathogenesis of cervical cancer, affecting several biological pathways and Hallmarks of Cancer, such as immune system regulation, cell cycle regulation, and energy metabolism. Thus, their analysis can contribute to the development of diagnostic and prognostic biomarkers and more effective treatments for cervical cancer.

Additionally, low expression of miR-557 and high expression of RAB10 in HCC tissues was closely associated with tumor size, degree of differentiation, TNM stage and poor prognosis in HCC patients. Taken together, these results demonstrate that miR-557 blocks the progression of HCC via the Wnt/β-catenin pathway by targeting RAB10.

miR-5571-5p up-regulation is associated with breast cancer progression and worse survival. The current study identified ten genes associated with breast cancer, which might help to provide candidate targets for the treatment.

Our findings verify that circ_0058063 acts as a sponge for miR-557 to upregulate DLGAP5 expression. These findings suggest that the circ_0058063/miR-557/DLGAP5 axis is an important regulator of oncogenic function and may be a promising therapeutic target for BC.

Regarding miR-55745, the decrease in its levels is accompanied by a significant decrease in the MLD insp-esp ratio, calculated as the difference between inspiration and expiration (p=0.035), as well as in the inspired and exhaled P15 values (p=0.047 and p=0.046). Therefore, miR-55745 and miR-124 levels could be used as potential biomarkers for early stage prediction in support of imaging techniques, as they are associated with earlier onset clinical parameters (MLD and P15) related to lower tract entrapment.ConclusionOur results suggest that the combination of the three miRNAs, and especially miR-55745, would help to profile high-risk patients for screening, improve early diagnosis and reduce lung cancer mortality.

The circ_0024107/miR‑5572/6855‑5p/CPT1A axis was deregulated in gastric cancer tissues and GC‑MSCs, and was associated with lymph node metastasis and the prognosis of patients with gastric cancer. Taken together, the findings of the present study suggest the crucial role of FAO metabolic reprogramming mediated by GC‑MSC‑derived circ_0024107 in synergistically promoting gastric cancer lymphatic metastasis via miR‑5572/6855‑5p‑CPT1A signaling; this suggests that circ_0024107 may be an attractive target for gastric cancer intervention.

This study identified DE m7G-related miRNAs and demonstrated their prediction ability in the prognosis of LUAD patients. The risk signature based on these miRNAs demonstrates high accuracy in predicting the prognosis of LUAD patients.