^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR549A (MicroRNA 549a)

    i
    Other names: MIR549A, MicroRNA 549a, Hsa-Mir-549, MicroRNA 549, MIRN549, MIR549, Hsa-MiR-549a-5p, Hsa-MiR-549a-3p, Hsa-Mir-549a, MIMAT0037328, MIMAT0003333, MI0003679, Mir-549a, RF00965
    Associations

    News

    Trials
    10d
    miR-195 and miR-549a Are Essential Biomarkers for Early-Onset Colorectal Cancer. (PubMed, Int J Mol Sci)
    This preliminary report highlights a 25-gene deregulated signature in EO-CRC, in which hsa-miR-195 and hsa-miR-549a emerge as biomarkers of clinical relevance, regulating key genes involved in angiogenesis, migration, and invasion. Their dysregulation could contribute to the aggressive clinical features and poor outcomes observed in EO-CRC.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • MIR195 (MicroRNA 195) • MIR549A (MicroRNA 549a)
    almost2years
    Blood miRNAs miR-549a, miR-552, and miR-592 serve as potential disease-specific panels to diagnose colorectal cancer. (PubMed, Heliyon)
    Considering the strong associations of these three identified miRNAs with CRC, they can collectively serve as a panel for specific discrimination of CRC from other types of cancer within the body. Although this study focused solely on CRC, this approach can potentially be applied to other cancer types as well.
    Journal
    |
    MIR549A (MicroRNA 549a)
    over3years
    Withaferin A mediated changes of miRNA expression in breast cancer-derived mammospheres. (PubMed, Mol Carcinog)
    An increase in miR-let-7c-5p expression was noted after WA treatment, with a simultaneous decrease in CCND1 and c-MYC at mRNA and protein levels. Taken together, our study demonstrated WA-mediated miRNA expression, in particular, upregulation of miR-let-7c-5p, leads to the inhibition of breast cancer cells derived mammospheres.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CCND1 (Cyclin D1) • CD44 (CD44 Molecule) • IGF1 (Insulin-like growth factor 1) • SOX2 • MIR34A (MicroRNA 34a-5p) • POU5F1 (POU Class 5 Homeobox 1) • Let-7c (MicroRNA Let-7c) • MIR99A (MicroRNA 99a) • NANOG (Nanog Homeobox) • MIR1247 (MicroRNA 1247) • MIR181A1 (MicroRNA 181a-1) • MIR549A (MicroRNA 549a)
    |
    MYC expression • CCND1 expression