MIR548AH (MicroRNA 548ah)

In the present study, we demonstrate, for the first time, altered expression of plasma-derived miRNAs in patients with CLL and MM exposed to pesticides. The plasma miRNAs identified may serve as promising candidates for biomarkers of pesticides effects, potentially contributing to the emerging field of Precision Environmental Health.

Both panels exhibit potential for patient classification in diagnostic and prognostic applications, highlighting the significance of liquid biopsy in advancing cancer screening methodologies.

The combination of six plasma exosome small RNAs has good prognostic value for women with positive breast cancer by imaging screening. The chemokine signaling pathway may be involved in the early stage of breast cancer. It is worth further exploring whether small RNAs mediate chemokine signaling pathways in the pathogenesis of breast cancer through the delivery of exosomes.

OVCAR-3 Resistant Subtypes (Olaparib Resistant Monolayer and Carboplatin Resistant Monolayer) were included in RT-qPCR panel.Results OCSC traits of spheroid enriched OVCAR-3 culture were substantially increased. After a broad validation process, downregulated hsa-miR-548ah-3p and hsa-miR-let-7b-5p and upregulated hsa-miR-146a-5p and hsa-miR-146b-5p were shown to correlate with spheroid formation ability and basal OCSC surface marker expressions of resistant OVCAR-3 Subtypes.Conclusion Selected miRNAs appears to have a role in OCSCs and resistance behavior. Further investigation is prospective to unravel their involvement in intrinsic/acquired resistance mechanisms and CSC relationships.