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    GENE:

    MIR506 (MicroRNA 506)

    i
    Other names: MIR506, miR-506, MicroRNA 506, Hsa-MiR-506-3p, Hsa-Mir-506, MIR506, Hsa-Mir-506-P1, MIMAT0022701, MIMAT0002878, MI0003193, MIRN506, Mir-506
    11d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    1m
    SPRED2 suppresses the stemness of hepatocellular carcinoma through the p53/miR-506-3p/KLF4 pathway. (PubMed, Cancer Biol Med)
    The current study revealed a novel SPRED2/p53/miR-506-3p/KLF4 axis through which SPRED2 contributes to the suppression of HCC cell stemness and provides a potential new target to prevent HCC progression.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • KLF4 (Kruppel-like factor 4) • MIR506 (MicroRNA 506) • NANOG (Nanog Homeobox) • SPRED2 (Sprouty Related EVH1 Domain Containing 2)
    1m
    The NEAT1/miR-506-3p/STAT3 axis promotes uveal melanoma progression and represents a potential therapeutic target. (PubMed, Cancer Cell Int)
    Rescue experiments further confirmed these interactions, contributing to a comprehensive understanding of the NEAT1/miR-506-3p/STAT3 axis in UM. The NEAT1/miR-506-3p/STAT3 axis has emerged as a promising diagnostic and therapeutic target for UM, providing a novel perspective on the pathogenesis of this challenging malignancy.
    Journal
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    NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • MIR506 (MicroRNA 506)
    2ms
    Identification and experimental validation of biomarkers associated with paraptosis in meningioma. (PubMed, Medicine (Baltimore))
    ITPR3, MAPK1, and MAPK8 are biomarkers for meningioma, all targeted by SMAD3. Tamoxifen could treat meningioma by affecting paraptosis pathways, offering a promising basis for targeted therapy development.
    Journal
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    MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MAPK1 (Mitogen-activated protein kinase 1) • MIR17HG (MiR-17-92a-1 Cluster Host Gene) • MIR506 (MicroRNA 506) • MIR92A1 (MicroRNA 92a-1) • MAPK8 (Mitogen-activated protein kinase 8) • MIR130A (MicroRNA 130a) • NORAD (Non-Coding RNA Activated By DNA Damage) • SMAD3 (SMAD Family Member 3)
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    tamoxifen
    5ms
    miR-340 reverses chemotherapy resistance in colon cancer via the PDCD4/WNT/β-catenin signalling pathway. (PubMed, Sci Rep)
    Moreover, miR-340 directly targeted PDCD4 and promoted its transcription. In summary, our findings underscore the potential of miR-340 as a modulator of oxaliplatin resistance in CRC by suppressing the PDCD4/WNT/β-catenin signalling pathway, thereby offering new insights into therapeutic strategies aimed at improving the efficacy of chemotherapy in CRC.
    Journal • IO biomarker
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • BCL2 (B-cell CLL/lymphoma 2) • CCND1 (Cyclin D1) • MIR340 (MicroRNA 340) • MIR506 (MicroRNA 506) • WNT5B (Wnt Family Member 5B)
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    oxaliplatin
    5ms
    6-gingerol promotes apoptosis of ovarian cancer cells through miR-506/Gli3 signaling pathway activation. (PubMed, Front Oncol)
    Our results indicate that gingerol promoted the upregulation of miR-506, leading to the induction of apoptosis in ovarian cancer cells. This study supports the potential of 6-gingerol-based therapy for ovarian malignancies.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • BCL2L1 (BCL2-like 1) • BAX (BCL2-associated X protein) • GLI3 (GLI Family Zinc Finger 3) • MIR506 (MicroRNA 506)
    10ms
    Therapeutic potential of microRNA-506 in cancer treatment: mechanisms and therapeutic implications. (PubMed, Front Oncol)
    We also discuss the potential of miR-506 as a therapeutic target and its role in overcoming drug resistance in cancer treatment. Overall, these insights underscore the therapeutic potential of miR-506 and its promise in developing novel cancer therapies.
    Review • Journal
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    MIR506 (MicroRNA 506)
    1year
    Unraveling the complexity of HRD assessment in ovarian cancer by combining genomic and functional approaches: translational analyses of MITO16-MaNGO-OV-2 trial. (PubMed, ESMO Open)
    The study underscores the complexities of HRD assessment and advocates for a combined genomic and functional approach to enhance predictive accuracy in OvC treatment responses.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • RAD51 (RAD51 Homolog A) • MIR506 (MicroRNA 506)
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    HRD
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    carboplatin • paclitaxel
    over1year
    Systematic Analysis of miR-506-3p Target Genes Identified Key Mediators of Its Differentiation-Inducing Function. (PubMed, Genes (Basel))
    Our findings represent a significant advancement in understanding the mechanisms by which miR-506-3p induces neuroblastoma cell differentiation. Future investigations of the identified 13 genes are needed to fully define their functions and mechanisms in controlling neuroblastoma cell differentiation, the understanding of which may reveal additional targets for developing novel differentiation therapeutic agents.
    Journal
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    MIR506 (MicroRNA 506)
    over1year
    Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR-506-3p/AURKA axis. (PubMed, J Biochem Mol Toxicol)
    Additionally, AURKA reduced erastin-induced ferroptosis in HT29 cells. Depletion of circRNA_007630 exerts as a suppressive role in colon cancer through a novel miR-506-3p/AURKA pathway related to ferroptosis, and might become a novel marker for colon cancer.
    Journal
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    AURKA (Aurora kinase A) • MIR506 (MicroRNA 506)
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    erastin
    over1year
    Long non-coding RNA HOTTIP promotes renal cell carcinoma progression through the regulation of the miR-506 pathway. (PubMed, Aging (Albany NY))
    HOTTIP down-regulation attenuated cell proliferation, migration, and invasion, which could be rescued by miR-506 down-regulation. On the whole, this study revealed that the HOTTIP/miR-506 axis has a dominant impact on RCC progression and potentially provides a novel strategy for RCC diagnosis and therapy.
    Journal
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    MIR506 (MicroRNA 506) • HOTTIP (HOXA Distal Transcript Antisense RNA)
    over1year
    Association of 3'UTR variations of EGFR and KRAS oncogenes with clinical parameters in lung cancer tumours. (PubMed, Biol Cell)
    In this study, we show that hsa-miR-124-3p, hsa-miR-506-3p, hsa-miR-1290 and hsa-miR-6514-3p are particularly prominent in lung carcinoma in relation to these biological pathways and the roles that variations in the 3'UTR regions of oncogenes may play in the carcinogenesis process.
    Journal
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    EGFR (Epidermal growth factor receptor) • KRAS (KRAS proto-oncogene GTPase) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • MIR1290 (MicroRNA 1290) • MIR506 (MicroRNA 506) • MIR124-2 (MicroRNA 124-2) • MIR124-3 (MicroRNA 124-3)