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    GENE:

    MIR497HG (Mir-497-195 Cluster Host Gene)

    i
    Other names: MIR497HG, Mir-497-195 Cluster Host Gene, MIR195HG, Mir-497-195 Cluster Host Gene (Non-Protein Coding), NONHSAG020671.2, Lnc-SLC16A11-7, HSALNG0114226
    over1year
    The mechanism and therapeutic potential of lncRNA MIR497HG/miR-16-5p axis in breast cancer. (PubMed, BMC Womens Health)
    In general, MIR497HG was decreased in breast cancer, and the MIR497HG/miR-16-5p axis regulated breast cancer tumorigenesis, providing effective insights for the diagnosis of patients.
    Journal
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    MIR16 (MicroRNA 16) • MIR497HG (Mir-497-195 Cluster Host Gene)
    almost3years
    MIR497HG-Derived miR-195 and miR-497 Mediate Tamoxifen Resistance via PI3K/AKT Signaling in Breast Cancer. (PubMed, Adv Sci (Weinh))
    The findings reveal that ZEB1-induced MIR497HG depletion contributes to breast cancer progression and tamoxifen resistance through PI3K-AKT signaling. MIR497HG can be used as a biomarker for predicting tamoxifen sensitivity in patients with ER+ breast cancer.
    Journal • IO biomarker
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    ER (Estrogen receptor) • BCL2 (B-cell CLL/lymphoma 2) • MAP2K1 (Mitogen-activated protein kinase kinase 1) • CCND1 (Cyclin D1) • DNMT3B (DNA Methyltransferase 3 Beta) • HDAC1 (Histone Deacetylase 1) • MIR497 (MicroRNA 497) • MIR497HG (Mir-497-195 Cluster Host Gene) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR195 (MicroRNA 195)
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    ER positive
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    tamoxifen