MIR494 (MicroRNA 494)

In summary, new miRNA signatures of relevance in B-AL and B-Ly could be recognized in this study. Studies in larger cohorts are required to further validate these findings.

In particular, strategies that restore or inhibit miRNA activity using mimics or antagomiRs show promise in improving drug sensitivity and complementing current treatment options. Overall, emerging evidence supports the integration of miRNA profiling into precision oncology for SCLC, with the aim of refining diagnosis, risk assessment and therapeutic decision-making.

Bilberry pomace shows multitarget anticancer activity across BC models; translational studies should confirm mechanisms, refine dosing, and explore biomarker-guided use.

These findings highlight the transformative potential of exosomal ncRNAs in precision oncology, offering novel ways for non-invasive diagnostics, prognostic stratification, and targeted therapies in hematological malignancies. Additional studies are necessary to validate these biomarkers and explore their clinical applications.

MiR-126-5p, miR-150-5p, miR-214-3p, and miR-452-5p all showed a decrease in expression at at least one timepoint following splenectomy. These miRNAs have been previously shown to have roles in angiogenesis and pathways known to be involved in the pathogenesis of hemangiosarcoma and may be prospective targets for a minimally invasive diagnostic panel for the presence of splenic hemangiosarcoma.

If a mass is not hemangiosarcoma, owners may be more likely to proceed with surgery rather than euthanasia. Knowing that a mass is hemangiosarcoma will provide information to owners on the need for adjuvant therapy following surgery.

A single week of LCD induces swift, pathway-linked shifts in plasma exosomal miRNAs in T2D. miR-494-3p and miR-362-5p emerge as promising early biomarkers for long-term glycaemic improvement and weight reduction, respectively.

[This retracts the article DOI: 10.21037/tcr-19-2195.].

In vivo experiments further confirmed that TBX5-AS1 overexpression significantly inhibited tumor growth, accompanied by upregulation of ATF6 and ER stress-related proteins. TBX5-AS1 functioned as a tumor-suppressive lncRNA by activating ER stress signaling through the miR-494-3p/ATF6 axis, thereby inhibiting LC growth and tumor stemness.

Changes in SLC5A8 expression did not alter the whole transcriptome significantly. This study shows microRNA-dependent regulation of SLC5A8 expression and underlines the potential effectiveness of simultaneous inhibition of a few microRNAs to derepress their common target.

Downregulation of miR-142, miR-146a, and miR-155 in CTCL cell lines using specific antagomirs significantly decreased cell proliferation and increased apoptosis of malignant cells. Overall, detailed bioinformatics analysis, followed by experimental validation in CTCL plasma, tissues, and cell lines, indicated that detection of miR-142, miR-146a, and miR-155 upregulation by liquid biopsy may represent a potential non-invasive diagnostic technique as well as a new therapeutic targeting approach for early-stage MF.

The results showed secretomes improved kidney histopathology by inducing regulatory changes in the expression levels of microRNAs (miRNAs). The results of this research showed that secretomes extracted from kidney stem cells can play a role in reducing kidney damage by regulating miRNAs related to AKI.