MIR486-1 (MicroRNA 486-1)

However, substantial methodological heterogeneity was observed. Overall, salivary miRNAs-particularly exosomal-represent promising biomarkers for OSCC and HNSCC, although standardized protocols and large-scale validation studies are required for clinical translation.

These miRNAs may serve as a potential diagnostic, prognostic, and therapeutic biomarkers for skin cancer. Future studies are needed to improve methods for FFPE analysis and to validate the key differences in miRNA signatures involved in skin cancer development.

In the training and validation sets, the area under the curve of the 4-miRNA panel was 0.909 and 0.942, respectively. These findings suggest that the serum glycosylated exosomal 4-miRNA panel developed using the GlyExo-Capture approach may serve as a promising strategy for liquid biopsy-based early detection of LUAD.

In multivariable analysis, both miR-21 (HR = 1.75, p = 0.023) and miR-486 (HR = 1.68, p = 0.031) remained independent predictors of poor OS after adjusting for clinical covariates. Elevated miR-21 and miR-486 expression predicts aggressive tumor behavior and poor survival after precise nodule resection, highlighting their potential as biomarkers for postoperative risk stratification.

Overall, the lineage-aligned synthesis indicates that NF-PitNETs progress through diverse molecular pathways, with each subtype dominated by distinct regulatory networks. Although many biomarkers show promise, most remain exploratory, highlighting the need for harmonised methods and multicentre validation to support precision diagnostics and prognostic modelling.

These genes likely mediate their effects by influencing immune cell infiltration, participating in immune regulation, and modulating inflammatory responses. Our findings offer new insights into drug selection and immunotherapeutic strategies for SS.

The differentially expressed miRNAs did not cluster the control cohorts except for the chronic kidney disease cohort, which showed some clustering based on proteinuria status. Altogether, the miRNAs showed potential to identify early kidney function decline and may target key kidney cells, mRNAs, proteins and pathogenic mechanisms in DKD.

Predictively, miRNAs such as miR-21 and miR-486-3p correlate with sorafenib resistance, while tissue and exosomal miRNAs forecast recurrence and survival after curative therapy...Despite technical and delivery challenges, early-phase trials validate target engagement and inform safety optimization. In this review, we highlight opportunities to integrate miRNA biomarkers into surveillance algorithms and combine miRNA therapeutics with existing modalities, charting a roadmap toward precision-guided management of HCC.

Methods We studied blood expression of 14 miRNAs in 30 subjects with GB, before and after surgery, and 30 healthy controls. Results Statistical analysis allowed us to select a panel of 3 miRNAs (miR-340-5p, miR-369-3p, miR-486-5p) with excellent diagnostic and prognostic accuracy in GB.

miRNA-1972 is a strong prognostic marker in non-viral HCC. Dysregulation of several other miRNAs relates to pathological variables such as amount of stroma within tumor, microvascular invasion and micronodularity.

Therefore, the editors have lost confidence in the data presented and have decided to retract the article. The authors and their affiliated institution were informed about the concerns and the decision to retract, but they remained unresponsive.

Serum APE1-AAbs, PTX-3, and miR-486-3p levels are higher in CRC patients with postoperative recurrence and metastasis. These three markers are risk factors for postoperative recurrence and metastasis in CRC and can be used as predictive biomarkers. The combined detection of these markers has higher predictive value compared to individual tests.