^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR483 (MicroRNA 483)

    i
    Other names: MicroRNA 483, Hsa-Mir-483, Hsa-MiR-483-5p, Hsa-MiR-483-3p, MIRN483, Mir-483, MIR483
    Associations

    News

    Trials
    2ms
    Integrative Regulatory Networks of MicroRNA-483: Unveiling Its Systematic Role in Human Diseases and Clinical Implications. (PubMed, Biomolecules)
    By mapping miR-483 regulatory circuits across multiple diseases, we define the molecular determinants of its context-dependent activity. These findings establish miR-483 as both a diagnostic biomarker and a therapeutic target whose function is dictated by cellular context.
    Review • Journal
    |
    TGFB1 (Transforming Growth Factor Beta 1) • MIR483 (MicroRNA 483)
    2ms
    Clinicopathological data and the role of miRNA expression in patients with pheochromocytomas/paragangliomas. (PubMed, Front Endocrinol (Lausanne))
    PD-L1 expression in a subset of cases highlights immune checkpoint inhibition as a potential therapeutic strategy. Prospective validation is warranted.
    Retrospective data • Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • MSI (Microsatellite instability) • MIR16 (MicroRNA 16) • MIR15A (MicroRNA 15a) • MIR183 (MicroRNA 183) • MIR483 (MicroRNA 483)
    |
    PD-L1 expression
    2ms
    In-silico pharmacological insights into the therapeutic potential of microRNAs for microplastic-associated cancers. (PubMed, Front Cell Dev Biol)
    Priorities for validation include reporter assays, gene/protein modulation, phenotypic rescue, and in vivo testing in MP-exposed models. Collectively, our results nominate miRNAs as candidate tools to interrogate and potentially mitigate MP-associated carcinogenic mechanisms.
    Review • Journal
    |
    MIR331 (MicroRNA 331) • MIR370 (MicroRNA 370) • MIR490 (MicroRNA 490) • MIR638 (MicroRNA 638) • MIR760 (MicroRNA 760) • MIR138 (MicroRNA 138) • MIR483 (MicroRNA 483) • MIR520A (MicroRNA 520a) • MIR532 (MicroRNA 532)
    3ms
    UTP3: A Prognostic Marker in Hepatocellular Carcinoma and Its Role in Immunity and Epigenetics. (PubMed, J Biochem Mol Toxicol)
    A nomogram centered on UTP3 yielded a 1-year AUC of 0.693. This multi-omics study establishes UTP3 as a key regulator connecting epigenetic alterations, immune suppression, and tumor progression in LIHC.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    PD-L1 (Programmed death ligand 1) • SNHG5 (Small Nucleolar RNA Host Gene 5) • MIR483 (MicroRNA 483) • SNHG15 (Small Nucleolar RNA Host Gene 15)
    |
    PD-L1 expression
    3ms
    Identification of anoikis-related genes and immune infiltration characteristics in Sjögren's syndrome based on machine learning. (PubMed, Front Med (Lausanne))
    These genes likely mediate their effects by influencing immune cell infiltration, participating in immune regulation, and modulating inflammatory responses. Our findings offer new insights into drug selection and immunotherapeutic strategies for SS.
    Journal • IO biomarker
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • BIRC3 (Baculoviral IAP repeat containing 3) • S100A9 (S100 Calcium Binding Protein A9) • MIR30B (MicroRNA 30b) • IFI27 (Interferon Alpha Inducible Protein 27) • IL15 (Interleukin 15) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIR486-1 (MicroRNA 486-1)
    3ms
    Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA. (PubMed, Front Oncol)
    This integrative model effectively predicted 1-, 3-, and 5-year survival probabilities, thereby stratifying patients into distinct risk categories for enhanced clinical decision-making and personalized follow-up strategies. This research validates the diagnostic and prognostic utility of exosomal miRNA models in MM, emphasizing their discriminative and predictive capabilities.
    Journal
    |
    MIR192 (MicroRNA 192) • MIR193B (MicroRNA 193b) • MIR10B (MicroRNA 10b) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIRLET7B (MicroRNA Let-7b)
    4ms
    A microRNA CRISPR screen reveals microRNA-483-3p as an apoptotic regulator in prostate cancer cells. (PubMed, Cell Death Dis)
    Mechanistically, we uncovered a novel regulatory axis wherein miR-483-3p directly modulates a BCLAF1/PUMA/BAK1 apoptotic signaling network, highlighting its critical role in maintaining PCa cell survival. Our findings provide novel insights into the complex regulatory role of miRNA in PCa progression and offer a potential therapeutic strategy for targeting miRNA-mediated pathways in metastatic disease.
    Journal
    |
    BAK1 (BCL2 Antagonist/Killer 1) • BCLAF1 (BCL2 Associated Transcription Factor 1) • MIR483 (MicroRNA 483)
    4ms
    Automated Microfluidic Platform for Single Spheroid Culture and Extracellular Vesicle Isolation: Application to Spheroid Transcriptomic Profiling. (PubMed, Small)
    Using adrenocortical carcinoma spheroids as a model, this work demonstrates that inhibiting β-catenin signaling selectively reduces the levels of EV-derived miR-139-5p and miR-483-5p, consistent with prior findings from 2D culture studies. This platform represents a groundbreaking approach to EV profiling at the single-spheroid level, unlocking new opportunities for personalized medicine, drug discovery, and targeted therapies by enabling the analysis of cellular heterogeneity and scarce biological samples such as patient-derived organoids.
    Journal
    |
    MIR139 (MicroRNA 139) • CD81 (CD81 Molecule) • MIR483 (MicroRNA 483)
    5ms
    Epigenetic Alterations in Hepatocellular Carcinoma: Mechanisms, Biomarkers, and Therapeutic Implications. (PubMed, Pharmaceuticals (Basel))
    Furthermore, specific epigenetic signatures such as CDH1 promoter hypermethylation and HOTAIR overexpression are being explored as potential biomarkers for early detection and treatment response. In this chapter, we review recent advances in the epigenetic landscape of HCC and discuss their diagnostic and therapeutic implications, highlighting their potential to improve patient outcomes through personalized medicine approaches.
    Review • Journal
    |
    CDH1 (Cadherin 1) • HOTAIR (HOX Transcript Antisense RNA) • MIR375 (MicroRNA 375) • MIR483 (MicroRNA 483)
    5ms
    Antitumor Potential of Epigallocatechin Gallate in Overcoming Molecular Therapy Resistance in Hepatocellular Carcinoma. (PubMed, Anticancer Res)
    EGCG effectively counters resistance to molecular therapies in HCC by modulating stress-response proteins, RTK signaling, and miRNA profiles. miR-575 appears to mediate its antitumor activity, suggesting potential therapeutic value for EGCG and miR-575-based strategies in treating resistant HCC.
    Journal
    |
    EGFR (Epidermal growth factor receptor) • MIR483 (MicroRNA 483)
    |
    EGFR expression
    |
    sorafenib • Lenvima (lenvatinib)
    5ms
    Early changes in exosomal microRNAs after a one-week low-calorie diet predict sustained glycaemic and weight outcomes in patients with type 2 diabetes. (PubMed, Food Funct)
    A single week of LCD induces swift, pathway-linked shifts in plasma exosomal miRNAs in T2D. miR-494-3p and miR-362-5p emerge as promising early biomarkers for long-term glycaemic improvement and weight reduction, respectively.
    Journal
    |
    IL6 (Interleukin 6) • MIR126 (MicroRNA 126) • MIR494 (MicroRNA 494) • MIR122 (MicroRNA 122) • MIR454 (MicroRNA 454) • MIR483 (MicroRNA 483)
    8ms
    Expression of Concern. (PubMed, Eur Rev Med Pharmacol Sci)
    Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway...PMID: 33577026. The Publisher apologizes for any inconvenience this may cause.
    Journal
    |
    IGF2 (Insulin-like growth factor 2) • MIR200B (MicroRNA 200b) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • FUS (FUS RNA Binding Protein) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • FOXO3 (Forkhead box O3) • PCNA (Proliferating cell nuclear antigen) • GAS5 (Growth Arrest Specific 5) • SMAD7 (SMAD Family Member 7) • DSCAM (DS Cell Adhesion Molecule) • HOXA-AS2 (HOXA Cluster Antisense RNA 2) • MIR29A (MicroRNA 29a) • MIR483 (MicroRNA 483) • MMP7 (Matrix metallopeptidase 7) • RBM24 (RNA Binding Motif Protein 24) • SNHG7 (Small Nucleolar RNA Host Gene 7) • TGFBR1 (Transforming Growth Factor Beta Receptor 1) • TGIF2 (TGFB Induced Factor Homeobox 2) • WTAP (WT1 Associated Protein) • XIST (X Inactive Specific Transcript) • MAGI2-AS3 (MAGI2 Antisense RNA 3)
    |
    cisplatin