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    GENE:

    MIR4664 (MicroRNA 4664)

    i
    Other names: MIR4664, MicroRNA 4664, Hsa-Mir-4664, Hsa-MiR-4664-5p, MIR4664
    3ms
    MiR-4664-3p as a potential diagnostic, prognostic, and immunotherapeutic biomarker in NSCLC: modulation of tumor progression through CD8 + T cell regulation. (PubMed, Front Oncol)
    These results suggest that the miR-4664-3p/PRKCB axis is crucial in NSCLC progression and immune modulation. Hence, MiR-4664-3p is a potential diagnostic and prognostic indicator, as well as therapeutic target in immunotherapy strategies for NSCLC.
    Journal • IO biomarker
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    CD8 (cluster of differentiation 8) • PRKCH (Protein Kinase C Eta) • MIR4664 (MicroRNA 4664) • PRKCB (Protein Kinase C Beta)
    over1year
    Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer. (PubMed, Thorac Cancer)
    The present study revealed the antioncogenic role of circ-36683 in suppressing cell proliferation and migration and highlighted that targeting the circ-36683/miR-4664-3p/CDK2AP2 axis is a promising strategy for the intervention of NSCLC.
    Journal • Circular RNA
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    TP53 (Tumor protein P53) • CCNE1 (Cyclin E1) • CDK2 (Cyclin-dependent kinase 2) • AGO2 (Argonaute RISC Catalytic Component 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • MIR4664 (MicroRNA 4664)
    2years
    High-throughput RNA sequencing identifies the miRNA expression profile, target genes, and molecular pathways contributing to growth of sporadic vestibular schwannomas. (PubMed, Acta Neurochir (Wien))
    We identified a set of 9 miRNAs that are significantly deregulated in large VS in comparison to small, intracanalicular tumors. The functional enrichment analysis of these miRNAs suggests novel mechanisms, such as that lipid metabolism, as well as Hippo and FOxO signaling pathways that may play an important role in VS growth regulation.
    Journal
    |
    CCND1 (Cyclin D1) • MIR155 (MicroRNA 155) • MIR142 (MicroRNA 142) • MIR7 (MicroRNA 7) • JARID2 (Jumonji And AT-Rich Interaction Domain Containing 2) • MIR1269A (MicroRNA 1269a) • MIR4664 (MicroRNA 4664) • LMNB2 (Lamin B2) • MIR204 (MicroRNA 204) • MIR342 (MicroRNA 342)
    |
    miR-155 expression
    over3years
    Application of miRNA Biomarkers in Predicting Overall Survival Outcomes for Lung Adenocarcinoma. (PubMed, Biomed Res Int)
    7 miRNAs were identified as novel biomarkers for the prognosis of patients with LUAD. This study offered a deeper comprehension of LUAD treatment and prognosis from the molecular level and helped enhance the understanding of the pathogenesis and potential molecular events of LUAD.
    Journal
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    HOXC8 (Homeobox C8) • MIR126 (MicroRNA 126) • MIR4664 (MicroRNA 4664) • CEP55 (Centrosomal Protein 55) • EGLN3 (Egl-9 Family Hypoxia Inducible Factor 3) • MIR19A (MicroRNA 19a) • MIR671 (MicroRNA 671)
    over3years
    Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma. (PubMed, Genet Res (Camb))
    Our results also identified a lncRNA MEG3/miR-195-3p/RAB1A/TM9SF3 regulatory axis, which may also play an important role in the progression of LUAD. Further study needs to be conducted to verify this result.
    Journal
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    MIR1293 (MicroRNA 1293) • MIR4664 (MicroRNA 4664) • MIR494 (MicroRNA 494) • MIR584 (MicroRNA 584) • MEG3 (Maternally Expressed 3) • MIR195 (MicroRNA 195)
    4years
    The Relationship between MicroRNA Expression Profiling in Imatinib-Resistant Cell Line K562/G and Potential Mechanism through FOXO3/Bcl-6 Signaling Pathway (PubMed, Zhongguo Shi Yan Xue Ye Xue Za Zhi)
    The FOXO3/Bcl-6 signaling pathway contributes to imatinib resistance in K562/G cell line, and the miRNA expression profiles showed significant differences between K562/G and K562 cells.
    Preclinical • Journal
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    BCL6 (B-cell CLL/lymphoma 6) • FOXO3 (Forkhead box O3) • MIR4664 (MicroRNA 4664)
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    imatinib