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    GENE:

    MIR4417 (microRNA 4417)

    i
    Other names: MIR4417, microRNA 4417, MIR-4417
    Associations

    News

    Trials
    over3years
    Identification of the Regulatory Targets of miR-3687 and miR-4417 in Prostate Cancer Cells Using a Proteomics Approach. (PubMed, Int J Mol Sci)
    The tumor protein D52 isoform 1 (TD52-IF1), which regulates neuroendocrine trans-differentiation, was found to be substantially deregulated in androgen-insensitive cells by both miR-3687 and miR-4417. These findings show that these miRNAs potentially support the CRPC by truncating the TD52-IF1 expression after the onset of androgen resistance.
    Journal
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    MIR3687-1 (microRNA 3687-1) • MIR4417 (microRNA 4417)
    over3years
    Myc manipulates the miRNA content and biologic functions of small cell lung cancer cell-derived small extracellular vesicles. (PubMed, Mol Biol Rep)
    Small extracellular vesicles and MYC are essential targets for therapeutic strategy in SCLC. Our study revealed that the expression level of MYC can affect the function of sEVs and encapsulate the miRNA composition in SCLC. Besides, small extracellular vesicles derived from SCLC cells can modulate normal lung cells.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • MIR7 (MicroRNA 7) • MIR181A1 (MicroRNA 181a-1) • MIR4417 (microRNA 4417) • MIR455 (MicroRNA 455)
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    MYC overexpression • MYC expression