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    GENE:

    MIR4306 (MicroRNA 4306)

    i
    Other names: MIR4306, MicroRNA 4306, Hsa-Mir-4306, Hsa-MiR-4306, MIMAT0016858, MI0015836, Mir-4306
    Associations

    News

    Trials
    3ms
    Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics. (PubMed, Eur J Med Res)
    These findings offer new insights into the occurrence and development of IDD and provide certain reference value for the subsequent diagnosis and treatment of IDD.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • CAPRIN1 (Cell Cycle Associated Protein 1) • MIR508 (MicroRNA 508) • MIR4306 (MicroRNA 4306) • MIR5100 (MicroRNA 5100) • POSTN (Periostin)
    4ms
    Screening and regulatory mechanisms of biomarkers related to neddylation in laryngeal squamous cell carcinoma. (PubMed, Front Mol Biosci)
    WSB2 and COMMD2 jointly predicted that hsa-miR-185-5p, hsa-miR-4644 and hsa-miR-4306 were the common microRNAs (miRNAs) and regulatory networks. This study successfully established a neddylation-associated prognostic risk model for LSCC and revealed that COMMD2, WSB2, and CUL9 could act as new therapeutic targets, which might provide valuable information for the research and treatment of LSCC.
    Journal
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    WSB2 (WD Repeat And SOCS Box Containing 2) • miR-185 (MicroRNA 185) • MIR4306 (MicroRNA 4306) • CUL9 (Cullin 9) • MIR4644 (MicroRNA 4644)
    11ms
    Circ_0038632 Acts as a Sponge of miR-4306 to Facilitate Breast Cancer Progression Through Regulating CXCR4 Expression. (PubMed, J Biochem Mol Toxicol)
    Finally, circ_0038632 knockdown inhibited the BC tumor formation. In conclusion, circ_0038632 contributed to the malignant progression of BC via regulating miR-4306/CXCR4 axis.
    Journal
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    CXCR4 (Chemokine (C-X-C motif) receptor 4) • MMP2 (Matrix metallopeptidase 2) • MMP9 (Matrix metallopeptidase 9) • MIR4306 (MicroRNA 4306)
    almost2years
    KDM4A-AS1 Promotes Cell Proliferation, Migration, and Invasion via the miR-4306/STX6 Axis in Hepatocellular Carcinoma. (PubMed, Crit Rev Eukaryot Gene Expr)
    STX6 overexpression reversed the inhibitory influence of KDM4A-AS1 depletion on HCC malignant behavior. KDM4A-AS1 promotes HCC cell migration, invasion, and growth by upregulating STX6 via miR-4306.
    Journal
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    MIR4306 (MicroRNA 4306)
    over2years
    Prospectives of mirna gene signaling pathway in triple-negative breast cancer. (PubMed, Pathol Res Pract)
    Recent reports suggest an important role of miRNAs in tumor metastasis. We review here the important miRNAs and their signaling pathways implicated in the oncogenesis, progression, and metastasis of TNBCs.
    Review • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • ER (Estrogen receptor) • MIR155 (MicroRNA 155) • MIR200B (MicroRNA 200b) • MIR429 (MicroRNA 429) • MIR200A (MicroRNA 200a) • MIR211 (MicroRNA 211) • MIR221 (MicroRNA 221) • MIR508 (MicroRNA 508) • MIR17 (MicroRNA 17) • MIR182 (MicroRNA 182) • MIR206 (MicroRNA 206) • MIR506 (MicroRNA 506) • MIR127 (MicroRNA 127) • MIR136 (MicroRNA 136) • MIR145 (MicroRNA 145) • MIR148A (MicroRNA 148a) • MIR195 (MicroRNA 195) • MIR218 (MicroRNA 218) • MIR22 (MicroRNA 22) • MIR26A1 (MicroRNA 26a-1) • MIR4306 (MicroRNA 4306)
    over2years
    Development and Validation of a Urinary microRNA Biomarker Panel as a Tool for Early Detection of Prostate Cancer in a Chinese Population. (PubMed, Biomarkers)
    Optimization of multi-miRNA panels resulted in a 6-miRNA biomarker panel (hsa-miR-375, hsa-miR-520d-5p, hsa-miR-199b-5p, hsa-miR-518e-5p, hsa-miR-31-3p and hsa-miR-4306) that had an AUC of 0.750. We identified a urinary miRNA biomarker panel for early detection of PCa in a Chinese population.
    Journal
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    MIR199B (MicroRNA 199b) • MIR31 (MicroRNA 31) • MIR375 (MicroRNA 375) • MIR4306 (MicroRNA 4306)
    almost4years
    Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1β via circPDE4D/miR-4306/SOX9 cascade. (PubMed, Immunopharmacol Immunotoxicol)
    CircPDE4D and SOX9 were competing endogenous RNAs (ceRNAs) for miR-4306, and circPDE4D could positively regulate SOX9 expression via miR-4306. CircPDE4D and miR-4306 were important regulators in regulating IL-1β-induced HNC apoptosis and matrix degradation via regulating the key transcription factor SOX9, suggesting a novel circPDE4D/miR-4306/SOX9 ceRNA pathway in OA-related chondrocyte dysfunction.
    Journal • IO biomarker
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    IL6 (Interleukin 6) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • SOX2 • BAX (BCL2-associated X protein) • CASP3 (Caspase 3) • SOX9 (SRY-Box Transcription Factor 9) • IL1B (Interleukin 1, beta) • ANXA5 (Annexin A5) • MIR4306 (MicroRNA 4306)
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    BCL2 expression • SOX9 expression