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    GENE:

    MIR381 (MicroRNA 381)

    i
    Other names: MIR381, MicroRNA 381, Hsa-Mir-381, Hsa-MiR-381-3p, Hsa-Mir-154-P9, MIRN381
    1m
    Transcriptomics driven identification of hub gene miRNA interactions for biomarker and therapeutic target discovery in gynecological cancers. (PubMed, Front Oncol)
    The identified miRNAs exhibit strong regulatory interactions with these hub genes, while serine/threonine protein kinases emerged as the most significantly associated group. Together, these findings highlight promising biomarker candidates and potential therapeutic targets for gynecological cancers.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • BIRC5 (Baculoviral IAP repeat containing 5) • AURKA (Aurora kinase A) • TGFB1 (Transforming Growth Factor Beta 1) • CCNB2 (Cyclin B2) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR381 (MicroRNA 381) • MIR495 (MicroRNA 495) • BUB1 (BUB1 Mitotic Checkpoint Serine/Threonine Kinase) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CCNB1 (Cyclin B1) • CDCA8 (Cell Division Cycle Associated 8) • MIR653 (MicroRNA 653)
    1m
    Comparative miRNA Expression Profiling Reveals Candidates Involved in Prostate Cancer Radioresistance. (PubMed, APMIS)
    Distinct mirna signatures differentiate radiation-resistant and radiation-sensitive prostate cancer cells. Mir-20a-5p, mir-128-3p, and mir-135b-5p may contribute to radioresistance, whereas mir-23b-3p and mir-381-3p may act as radiosensitizers.
    Clinical • Journal
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    MIR135B (MicroRNA 135b) • MIR23b (MicroRNA 23b) • MIR381 (MicroRNA 381) • MIR128 (MicroRNA 128) • MIR20A (MicroRNA 20a)
    2ms
    Subtype-Independent Dysregulation of the Notch Signaling Pathway and Its miRNA Regulators in Breast Cancer. (PubMed, Biomedicines)
    The consistent alterations suggest the presence of a shared Notch-driven oncogenic signature in breast cancer, potentially driving cell proliferation, stemness, and resistance to therapy. These findings enhance our understanding of Notch signaling in breast cancer and propose novel miRNA-Notch interactions as candidate targets for therapeutic intervention.
    Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • NOTCH4 (Notch 4) • APH1A (Aph-1 Homolog A, Gamma-Secretase Subunit) • CTBP1 (C-Terminal Binding Protein 1) • MIR381 (MicroRNA 381) • TLE2 (TLE Family Member 2, Transcriptional Corepressor) • HEY1 (Hes Related Family BHLH Transcription Factor With YRPW Motif 1) • MIR145 (MicroRNA 145) • MIR98 (MicroRNA 98) • TLE4 (TLE Family Member 4 Transcriptional Corepressor)
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    HER-2 positive • HER-2 negative
    2ms
    [Expression of Concern] lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis. (PubMed, Mol Med Rep)
    Owing to the fact that the Editorial Office has been made aware of potential issues surrounding the scientific integrity of this paper, we are issuing an Expression of Concern to notify readers of this potential problem while the Editorial Office continues to investigate this matter further. [Molecular Medicine Reports 23: 139, 2021; DOI: 10.3892/mmr.2020.11778].
    Journal
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    MIR381 (MicroRNA 381)
    2ms
    ING5-mediated regulation of lung cancer progression via the OIP5-AS1/miR-381-3p/SEC24A axis. (PubMed, Transl Cancer Res)
    Our cell-based and subcutaneous xenograft experiments suggest that ING5-mediated down-regulation of OIP5-AS1 may release miR-381-3p and consequently reduce SEC24A expression. However, this axis has not yet been validated in clinical specimens, and studies addressing metastasis or long-term toxicity are still needed.
    Journal
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    MIR381 (MicroRNA 381)
    3ms
    [Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer. (PubMed, Int J Mol Med)
    The Editor apologizes to the readership of the Journal for any inconvenience caused. [International Journal of Molecular Medicine 44: 593‑607, 2019; DOI: 10.3892/ijmm.2019.4206].
    Journal
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    ETS1 (ETS Proto-Oncogene 1) • MIR381 (MicroRNA 381)
    4ms
    The expression of miR-381-3p in acute myeloid leukemia and its effect on corresponding cell proliferation and apoptosis. (PubMed, Discov Oncol)
    miR-381-3p is low expressed in AML patients, and its overexpression can significantly prolong OS and PFS. miR-381-3p can promote apoptosis of AML cells, inhibit proliferation, and may become a targeted molecule for the treatment of AML.
    Journal
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    MIR381 (MicroRNA 381)
    6ms
    Pracinostat inhibits the nefarious biological behavior of pancreatic cancer by targeting the miR-381-3p/MDM2 axis to activate the p53 signaling pathway. (PubMed, Pathol Res Pract)
    pracinostat activates the p53 signaling pathway by targeting the miR-381-3p/MDM2 axis, thereby inhibiting the proliferation of pancreatic cancer cells. These findings provide novel insights and potential therapeutic strategies for pancreatic cancer, and may also provide a reference for the treatment of other malignancies.
    Journal
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    MDM2 (E3 ubiquitin protein ligase) • MIR381 (MicroRNA 381)
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    pracinostat (SB939)
    7ms
    Profiling miRNA changes in Epstein-Barr virus lytic infection identifies a function for BZLF1 in upregulating miRNAs from the DLK1-DIO3 locus. (PubMed, PLoS Pathog)
    In keeping with this timing, BZLF1 was sufficient to induce these lncRNAs dependent on its transactivation activity, and was detected at a key DLK1-DIO3 control element, consistent with a direct role in transcriptional activation. Therefore, we have identified a new role for BZFL1 in activating the expression of lncRNAs in the DLK1-DIO3 locus, resulting in induction of a subset of encoded miRNAs that promote lytic infection.
    Journal
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    MIR370 (MicroRNA 370) • MIR381 (MicroRNA 381) • MIR409 (MicroRNA 409) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    8ms
    Prognostic role of miR-190, miR-221, and miR-381 in breast cancer: a systematic review and meta-analysis. (PubMed, Eur Rev Med Pharmacol Sci)
    These findings underscore the potential of miR-190 and miR-381 as prognostic biomarkers. https://www.europeanreview.org/wp/wp-content/uploads/Graphical-Abstract-18-scaled.jpg.
    Clinical • Retrospective data • Review • Journal
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    MIR221 (MicroRNA 221) • MIR381 (MicroRNA 381)
    12ms
    Mast cell - tumor cell interaction related gene and microRNA expression profiles in oral squamous cell carcinoma. (PubMed, Front Oncol)
    The data highlight the complex and dynamic interplay between MCs and OSCC, driven by key signaling pathways and miRNA regulation. These findings provide a foundation for future functional studies and the possible development of targeted therapies aimed at modulating MC-OSCC interaction within the TME.
    Journal • IO biomarker
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    CCL2 (Chemokine (C-C motif) ligand 2) • TGFB1 (Transforming Growth Factor Beta 1) • MIR142 (MicroRNA 142) • CCR2 (C-C Motif Chemokine Receptor 2) • MIR223 (MicroRNA 223) • MIR381 (MicroRNA 381)