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    GENE:

    MIR375 (MicroRNA 375)

    i
    Other names: MIR375, MicroRNA 375, Hsa-Mir-375, Hsa-MiR-375, MIRN375, Hsa-Mir-375_pre, Hsa-MiR-375-5p, Hsa-MiR-375-3p, MIMAT0037313, MIMAT0000728, MI0000783, MiRNA375, Mir-375, RF00700
    11d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    14d
    Prognostic Stratification of Highly Differentiated Thyroid Cancer Based on Molecular Genetic Studies. (PubMed, Asian Pac J Cancer Prev)
    The practical significance of this work lies in the possibility of considering the identified genomic and epigenomic features when choosing surgical intervention and adjuvant therapy, thereby increasing the chances for long-term remission. Additionally, it emphasizes the standardization of analytical methods and the development of a unified system for evaluating the combined genetic alterations, which could enhance the quality of prognostic stratification and more effectively tailor treatment strategies.
    Review • Journal
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    BRAF (B-raf proto-oncogene) • RET (Ret Proto-Oncogene) • TERT (Telomerase Reverse Transcriptase) • MIR221 (MicroRNA 221) • MIR375 (MicroRNA 375) • MIR146B (MicroRNA 146b)
    27d
    Improved Safety of New MicroRNA-Regulated Oncolytic Coxsackievirus B3 Observed After Intravenous Administration in Colorectal-Tumor-Bearing Mice. (PubMed, Viruses)
    These data indicate that PD-H or microRNA-regulated PD derivatives exhibit only limited therapeutic efficacy following i.v. injection in colorectal tumor-bearing mice. However, the newly engineered microRNA-regulated PD-H variants demonstrate improved safety profiles.
    Preclinical • Journal
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    MIR375 (MicroRNA 375) • MIR122 (MicroRNA 122) • MIR145 (MicroRNA 145)
    1m
    Evaluation of microRNA Expression Profiles as Diagnostic and Prognostic Biomarkers in Oral Squamous Cell Carcinoma: A Molecular Approach. (PubMed, J Pharm Bioallied Sci)
    Differential expression of selected miRNAs suggests their potential as reliable biomarkers for early OSCC detection and prognosis. Integrating miRNA profiling may enhance precision diagnostics in oral oncology.
    Journal
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    MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR375 (MicroRNA 375)
    1m
    MicroRNAs as Diagnostic and Prognostic Biomarkers in Melanoma and Non-Melanoma Skin Cancers: An Updated Review. (PubMed, Diagnostics (Basel))
    Overall, current evidence supports miRNAs as promising diagnostic, prognostic, and predictive biomarkers in cutaneous oncology. Standardized methodologies and large-scale validation remain essential for their integration into routine clinical practice.
    Review • Journal
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    BRAF (B-raf proto-oncogene) • MIR34A (MicroRNA 34a-5p) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR31 (MicroRNA 31) • MIR375 (MicroRNA 375) • MIR128 (MicroRNA 128) • MIR145 (MicroRNA 145) • MIR181A1 (MicroRNA 181a-1) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR383 (MicroRNA 383)
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    BRAF mutation
    2ms
    MicroRNAs in Prostate Cancer Liquid Biopsies: Early Detection, Prognosis, and Treatment Monitoring. (PubMed, Cells)
    Although promising, clinical implementation of miRNA-based assays requires further validation, standardization of protocols, and large-scale prospective studies. Harnessing circulating miRNAs could usher in a new era of precision oncology for PCa, improving early diagnosis, prognostication, and real-time therapeutic guidance.
    Review • Journal • Liquid biopsy
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    MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR141 (MicroRNA 141) • MIR23b (MicroRNA 23b) • MIR375 (MicroRNA 375) • MIR20A (MicroRNA 20a) • MIR326 (MicroRNA 326)
    2ms
    The role of microRNAs in gastritis, intestinal metaplasia, and gastric cancer: a narrative review. (PubMed, Transl Cancer Res)
    Clinically, circulating miRNA panels (e.g., miR-4257, miR-6785-5p, and miR-187-5p) enhance early detection, while miR-125a-5p boosts the trastuzumab response via ERBB2 targeting...This review highlights miRNAs as pivotal regulators in gastric carcinogenesis and promising precision medicine tools. The study findings will promote the standardization of profiling methods and accelerate translational research, both of which are essential to the advancement of GC diagnostic and therapeutic strategies.
    Review • Journal
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    HER-2 (Human epidermal growth factor receptor 2) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • CDX2 (Caudal Type Homeobox 2) • FOXD1 (Forkhead Box D1) • MIR375 (MicroRNA 375) • MIR425 (MicroRNA 425) • MIR92A1 (MicroRNA 92a-1) • MIR125A (MicroRNA 125a) • MIR187 (MicroRNA 187) • MIRLET7B (MicroRNA Let-7b) • MIR6785 (MicroRNA 6785)
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    Herceptin (trastuzumab)
    2ms
    Assessment of miRNA 106a-5p and 375-3p Expression in the Context of the Wnt/β-Catenin Pathway-Comparison of Prostate Adenocarcinoma and Benign Prostatic Hyperplasia Tissues. (PubMed, Int J Mol Sci)
    Our study results revealed lower immunoreactivity and expression of genes encoding β-catenin, Fzd8, Wnt5a, and cyclin D1 and significantly higher fluorescence intensity of miRNA 106a-5p and 375-3p with prostate adenocarcinoma compared to BPH. These parallel alterations in miRNA expression and Wnt/β-catenin-related components reflect disease-specific expression patterns and warrant further investigation in larger cohorts to determine their potential utility as diagnostic biomarkers in prostate diseases.
    Clinical • Journal
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    CCND1 (Cyclin D1) • MIR106A (MicroRNA 106a) • MIR375 (MicroRNA 375)
    2ms
    Artificial Intelligence-Driven SELEX Design of Aptamer Panels for Urinary Multi-Biomarker Detection in Prostate Cancer: A Systematic and Bibliometric Review. (PubMed, Biomedicines)
    AI-assisted SELEX is a promising strategy for accelerating high-affinity aptamer discovery and assembling multiplex urinary panels for PCa, but current evidence is early phase, heterogeneous, and largely single-center. Priorities include standardized uEV processing, complete 2 × 2 diagnostic reporting, multicenter external validation, calibration and decision impact analyses, and harmonized LoD and Kd reporting frameworks.
    Review • Journal
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    ERG (ETS Transcription Factor ERG) • MIR21 (MicroRNA 21) • TMPRSS2 (Transmembrane serine protease 2) • MIR375 (MicroRNA 375) • PCA3 (Prostate cancer associated 3)
    2ms
    Innovative minicircle DNA vector encoding pri-miR-375 silences E6 and E7 oncoproteins in HPV16-positive CaSki cells. (PubMed, Gene)
    These results suggest that mcDNA-pri-miR-375 vector has the potential to be further explored in gene therapy for the treatment of HPV-caused cervical cancer.
    Journal
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    CASP3 (Caspase 3) • MIR375 (MicroRNA 375)
    2ms
    Vav1 Sustains the Expression of Insulin, PDX1 and miR-375 During Differentiation of hiPSCs to β Cells: A Potential Target to Improve the In Vitro Generation of Insulin-Producing Cells. (PubMed, Tissue Eng Regen Med)
    Our findings suggest the existence of a Vav1/PDX1/miR-375/Akt axis as part of the complex network orchestrating the generation of functional β cells. These insights indicate that strategies aimed at specifically modulating Vav1 levels may positively impact the generation of IPCs in vitro and, ultimately, β cell replacement therapy for T1D.
    Preclinical • Journal
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    MIR375 (MicroRNA 375) • PDX1 (Pancreatic And Duodenal Homeobox 1) • VAV1 (Vav Guanine Nucleotide Exchange Factor 1)
    3ms
    A novel biochip-based liquid biopsy for extracellular vesicle RNA detection in prostate cancer. (PubMed, Cancer Biol Ther)
    Key markers such as miR-141, miR-375, and PCA3 showed strong diagnostic and risk stratification value in PCa. This non-invasive approach holds promise for improving early detection and clinical risk assessment.
    Journal • Liquid biopsy
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    Let-7c (MicroRNA Let-7c) • MIR141 (MicroRNA 141) • MIR375 (MicroRNA 375) • PCA3 (Prostate cancer associated 3)