MIR361 (MicroRNA 361)

LncRNA MIAT is upregulated in HCC tissues. Silencing lncRNA MIAT can elevate miR-361-3p levels, inhibiting the proliferation and invasion of MHCC97L cell structures and promoting apoptosis.

These microRNAs have demonstrated to have both pro-ferroptotic and anti-ferroptotic effects across a variety of disease models through in-silico predictions and experimental validation in each case, depending on the dynamics of their expression. Therapeutic interventions using microRNA-mimics, antagomirs, and adjunct therapeutic methods utilising natural compounds show the potential to control ferroptosis by regulating GPX4, thus providing new opportunities for the treatment of ferroptosis-related diseases.

Our data suggest a potential dysregulated circRNA-miRNA-mRNA axis in HBV-integrated hepatocytes, which may indicate a poor prognosis for HBV-HCC patients.

By integrating leukocyte mRNA sequencing data with the Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Ontology (GO) databases, and Hallmark gene set, functional annotation identified enrichment in pathways related to amyloid beta metabolic process, axon guidance, and glioma, suggesting potential neurotoxic mechanisms of OPEs in humans. This study is the first to identify plasma miRNA profiles associated with trace-level OPEs exposure, highlighting the potential public health significance of low-level OPE exposure in disrupting neural regulation.

The AHALA framework offers a potent and efficient method of performing miRNA-based subtyping of breast cancer that integrates global exploration and local search to its advantage. Its high level of classification, stability, and ability to identify biologically important biomarkers mark this method as promising.

Moreover, 9 transcription factors (TFs) (like STAT1), 69 key microRNAs (miRNAs) (like hsa-miR-361-3p), and 78 long non-coding RNAs (lncRNAs) (like NEAT1) were found to have relationships with potential biomarkers, and potential biomarkers had stable binding affinity with adenosine diphosphate (ADP) and lonafarnib...Importantly, RT-qPCR confirmed higher expression of HSPA8, LMNA and SERPINH1 in CS patients. The findings suggested that HSPA8, LMNA and SERPINH1 might offer novel insights for the development of targeted therapies for CS associated with angiogenesis and ISR.

This study identifies distinct miRNA signatures associated with GBC initiation and progression, offering insights into the molecular pathogenesis of the disease. Furthermore, functional studies of the miRNAs implicated in EMT and EGFR-TKI resistance may be conducted using GBC cell lines to dissect the precise roles of key miRNAs and explore their potential as novel therapeutic targets in GBC.

The results show that downregulating LINC01106 significantly inhibited proliferation, migration, and invasion capabilities of GC cells, while inducing cell cycle arrest at the G2/M phase; mechanistically, LINC01106 regulate the expression of Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL) by sponging miR-361-3p; moreover, TME analysis reveale that high DTL expression was associated with reduced immune cell infiltration, decreased stromal cell proportion, and elevate tumor cell purity in GC tissues, with significant correlations also observed with immune checkpoint molecule expression. This study suggests that the LINC01106/miR-361-3p/DTL network accelerates GC progression by promoting cell cycle progression and remodeling the TME, providing a novel potential molecular target for targeted therapy of gastric cancer.

HY can also exert these effects by mediating the PI3K/AKT/mTOR signaling pathway through miR-361-5p, maintaining mitochondrial dynamic stability, alleviating mitochondrial dysfunction, and enhancing mitophagy. Additionally, in vivo, HY was able to significantly improve skin wrinkles in mice while reducing changes in thickness and aging of the epidermis and dermis.

Additionally, we explore the potential of targeting these molecules to enhance the efficacy of radiation therapy and improve patient outcomes. Our study contributes to the comprehension of the molecular processes underlying oral cancer and provides insights into the development of novel therapeutic strategies based on personalized medicine.

Circulating miRNAs, including hsa-miR-3619-3p, hsa-miR-1290, and hsa-miR-1185-2-3p, correlated with AFP levels and disease stage, underscoring their value as non-invasive biomarkers. These findings demonstrate that integrated analysis of tissue and serum miRNAs can identify clinically relevant biomarkers and potential therapeutic targets in HCC.

SYNPR-AS1 exerts pivotal functions in NSCLC through decoying miR-3619-5p and thereby regulating FOXK1 expression. The SYNPR-AS1/miR-3619-5p/FOXK1 axis may be an effective target for NSCLC therapy.