MIR340 (MicroRNA 340)

Bioinformatic analyses further revealed that expression of SENP6 and senescence-associated genes correlated with disease progression and patient survival in ovarian cancer cohorts. These findings identify a previously unrecognized epigenetic mechanism by which anisomycin induces senescence and death in OCSCs, suggesting that targeting the microRNA-340/SENP6/SUMOylation pathway may represent a promising therapeutic approach.

Extracellular delivery of miR-132-5p and miR-9-5p to co-cultures of iNeurons and iMGLs resulted in reduced neurite length. Our data establish that distinct CNS disease-associated miRNAs serve as signaling molecules for human microglia via TLR8, thereby controlling the diverse microglial functions and modulating the neuroinflammatory response.

Moreover, miR-340 directly targeted PDCD4 and promoted its transcription. In summary, our findings underscore the potential of miR-340 as a modulator of oxaliplatin resistance in CRC by suppressing the PDCD4/WNT/β-catenin signalling pathway, thereby offering new insights into therapeutic strategies aimed at improving the efficacy of chemotherapy in CRC.

The diagnostic model achieved an AUC of 0.956, a sensitivity of 94%, and a specificity of 93% in the training cohort and an AUC of 0.985, a sensitivity of 86%, and a specificity of 97% in the validation cohort. Our findings demonstrates that plasma sEV miRNA exhibits a highly discriminative biomarker for distinguishing NCs group from early malignant lesions, making it a promising tool for auxiliary detection of early-stage LC.

Methods We studied blood expression of 14 miRNAs in 30 subjects with GB, before and after surgery, and 30 healthy controls. Results Statistical analysis allowed us to select a panel of 3 miRNAs (miR-340-5p, miR-369-3p, miR-486-5p) with excellent diagnostic and prognostic accuracy in GB.

Through gene ontology enrichment analysis, we further elucidated the biological processes and pathways impacted by these miRNAs, providing insight into their contributions to CRC. The literature review did not identify any previously reported shared connection between these miRNAs, adiponectin signaling, and CRC pathogenesis.

Plasminogen activator urokinase receptor was differently expressed and positively correlated with an unfavorable prognosis in NSCLC. The MIRLET7BHG/hsa-miR-127-3p axis was identified as the most likely upstream ncRNA-related pathway for PLAUR in NSCLC. This study provides insights into the molecular mechanism of action of PLAUR in NSCLC, which may help to develop new drugs to regulate PLAUR expression or its function in tumor development and provide new targets for the treatment of NSCLC.

The results of this study indicate that microRNA-mediated regulation of DUSP2 in hematologic and solid cancers appears to be a plausible mechanism that contributes to the dysregulation of MAP kinase signaling pathways in cancer by impairing negative feedback regulation. The data provide a solid foundation for future studies to investigate the consequences of regulation of DUSP function in cancer in more depth.

Our exploration of upstream regulators revealed six and one reliable transcription factors for CCNJL and SLC29A4, respectively. This study delved into common biomarkers between STC and CRC, and developed a reliable prognostic signature for CRC.

Our findings establish TCP1 as a promising therapeutic target for AML. Both miR-340-5p and FTY720 demonstrate potent anti-leukemic effects by suppressing TCP1 activity, highlighting their potential as novel strategies to inhibit AML proliferation and improve therapeutic outcomes.