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    GENE:

    MIR324 (MicroRNA 324)

    i
    Other names: MIR324, MicroRNA 324, Hsa-Mir-324, Hsa-MiR-324-5p, Hsa-MiR-324-3p, MIRN324
    2ms
    PCAT7 Enhances Doxorubicin Resistance of Osteosarcoma by Modulating TGF-β Signalling. (PubMed, Folia Biol (Praha))
    These findings unveil a novel mechanism contributing to the constitutive activation of TGF-β signalling in osteosarcoma. Targeting PCAT7 may offer a promising avenue for therapeutic interventions in osteosarcoma by disrupting the aberrant TGF-β signalling, thus presenting a potential strategy to improve treatment outcomes in this challenging cancer.
    Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • MIR324 (MicroRNA 324) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)
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    doxorubicin hydrochloride
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    5ms
    Relationship between heavy metals and miRNAs in pancreatic ductal adenocarcinoma. (PubMed, J Trace Elem Med Biol)
    This study suggests that specific miRNAs correlate with metals in PDAC, such as miR-361-3p with Cu and miR-216a-5p with Mn, hinting at a potential role of metal homeostasis in tumour-related pathways. However, these findings warrant further validation and functional studies, and may provide novel insights for biomarker development and therapeutic strategies in PDAC.
    Journal
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    MIR324 (MicroRNA 324) • MIR20B (MicroRNA 20b) • MIR216A (MicroRNA 216a) • MIR361 (MicroRNA 361) • MIR125A (MicroRNA 125a)
    7ms
    A predictive serum miRNA signature impacts diffuse large B-cell lymphoma cell viability via inhibition of EGLN1 and TXNRD1 regulators of ferroptosis. (PubMed, Br J Haematol)
    In this study, we identified circulating miRNAs differentially expressed between R-CHOP refractory and responding subjects by small-RNA sequencing on serum from 33 DLBCL patients...EGLN1 and TXNRD1, regulators of oxygen metabolism and redox homeostasis, were identified as miRNA targets and the silencing or inhibition of these genes impaired cell viability and induced ferroptosis. These results support the application of a two-miRNA signature and its targets for novel combined therapeutic interventions in DLBCL.
    Journal
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    MIR324 (MicroRNA 324) • EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1)
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    Rituxan (rituximab)
    8ms
    Integrated genomic and molecular insights into astrocyte- and oligodendrocyte-derived amyotrophic lateral sclerosis: focus on miRNAs and extracellular vesicles. (PubMed, Cell Mol Biol (Noisy-le-grand))
    Then, after careful evaluation of the information, TP53, MDM2, KRAS, PTPRC, and GSK proteins were candidates, which are regulated by hsa-miR-564, hsa-miR-496-5p, hsa-miR-324-5p, hsa-miR-296-5p, and hsa-miR-4258-3p miRNAs. Finally, the four genes had a more robust and better relationship in this study between astrocyte and oligodendrocyte-derived ALS.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • TP53 (Tumor protein P53) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • MIR324 (MicroRNA 324) • MIR425 (MicroRNA 425)
    8ms
    Molecular mechanisms of TPT1-AS1 in regulating epithelial ovarian cancer cell invasion, migration, and angiogenesis by targeting the miR-324/TWIST1 axis (PubMed, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi)
    Conclusion TPT1-AS1 promotes EOC cell proliferation, invasion, migration and angiogenesis by negatively regulating the miR-324/TWIST1 axis, thus promoting the development of OC. These findings provide new potential targets for the diagnosis and treatment of OC.
    Journal
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    CDH1 (Cadherin 1) • VIM (Vimentin) • MIR324 (MicroRNA 324) • TWIST1 (Twist Family BHLH Transcription Factor 1)
    9ms
    Natural Compounds in Cancer Therapy: Revealing the Role of Flavonoids in Renal Cell Carcinoma Treatment. (PubMed, Biomolecules)
    Current clinical evidence, including a phase II trial of flavopiridol in advanced RCC, highlights the potential but also the need for further validation. In conclusion, flavonoids offer a promising approach to improving RCC treatment. Future research should focus on optimizing their therapeutic efficacy and ensuring their safe clinical translation, with the goal of achieving personalized and minimally invasive cancer therapies.
    Review • Journal
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    STAT3 (Signal Transducer And Activator Of Transcription 3) • YAP1 (Yes associated protein 1) • MIR21 (MicroRNA 21) • GPX4 (Glutathione Peroxidase 4) • MIR324 (MicroRNA 324)
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    alvocidib (DSP-2033)
    10ms
    Retraction Notice to: LncRNA LINC00963 Promotes Tumorigenesis and Radioresistance in Breast Cancer by Sponging miR-324-3p and Inducing ACK1 Expression. (PubMed, Mol Ther Nucleic Acids)
    [This retracts the article DOI: 10.1016/j.omtn.2019.09.033.].
    Journal
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    LINC00963 (Long Intergenic Non-Protein Coding RNA 963) • MIR324 (MicroRNA 324)
    11ms
    Clinical Significance of LINC00261 in the Pathogenesis of Pancreatic, Colorectal, Hepatocellular, and Gallbladder Cancer. (PubMed, Diseases)
    Further bioinformatic analysis revealed that LINC00261 regulates key cellular processes, such as protein-DNA complex formation, ribonuclease complex activity, histone deacetylase complexes, and nuclear matrix interactions. Overall, we believe that LINC00261 holds significant promise as a future biomarker and, when combined with existing treatment strategies, may enhance cancer patient care and survival.
    Review • Journal
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    mTOR (Mechanistic target of rapamycin kinase) • MIR324 (MicroRNA 324) • MIR23A (MicroRNA 23a) • MIR105 (MicroRNA 105) • MIR148A (MicroRNA 148a)
    1year
    Silencing of LINC01278 promotes sensitivity of non-small cell lung cancer cells to osimertinib by targeting miR-324-3p/ZFX axis. (PubMed, Cytotechnology)
    In conclusion, LINC01278 knockdown alleviates osimertinib resistance of NSCLC cells by regulating downstream miR-324-3p and ZFX. The online version contains supplementary material available at 10.1007/s10616-024-00673-8.
    Journal
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    EGFR (Epidermal growth factor receptor) • MIR324 (MicroRNA 324)
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    EGFR mutation • EGFR positive
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    Tagrisso (osimertinib)
    1year
    LncRNA SNHG16 Drives PD-L1-Mediated Immune Escape in Colorectal Cancer through Regulating miR-324-3p/ELK4 Signaling. (PubMed, Biochem Genet)
    Mechanistically, SNHG16 acted as a competitive endogenous RNA to enhance ELK4 expression by sponging miR-324-3p, thereby provoking the transcription of PD-L1. Our results demonstrated that SNHG16 silencing led to the suppression of cell growth, metastasis, and immune escape of CRC cells through mediating miR-324-3p/ELK4/PD-L1 axis, offering promising targets for CRC treatment.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • MIR324 (MicroRNA 324) • SNHG16 (Small Nucleolar RNA Host Gene 16)
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    PD-L1 expression