our Premium Content: News alerts, weekly reports and conference planners

GENE:

MIR3200 (MicroRNA 3200)

News alerts, weekly reports and conference planners

over1year

Diagnostic model for hepatocellular carcinoma using small extracellular vesicle-propagated miRNA signatures. (PubMed, Front Mol Biosci)

Receiver operating characteristic (ROC) curve analysis revealed an area under the curve (AUC) of 0.951, with a sensitivity of 90.1% and specificity of 87.8%. These aberrantly expressed miRNAs delivered by sEVs potentially contribute to HCC pathology and may serve as diagnostic biomarkers for HCC.

over 1 year ago

Journal

MIR3200 (MicroRNA 3200) • MIR140 (MicroRNA 140)

2years

VEGFR affects miR-3200-3p-mediated regulatory T cell senescence in tumour-derived exosomes in non-small cell lung cancer. (PubMed, Funct Integr Genomics)

In conclusion, inhibition of VEGFR2 expression in tumour cells promotes the expression of miR-3200-3p in exosomes secreted by tumour cells. miR-3200-3p enters the TME through exosomes and acts on DDB1 in Treg cells to promote senescence of Treg cells to inhibit tumour progression.

2 years ago

Journal

CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • GSTP1 (Glutathione S-transferase pi 1) • DDB1 (Damage Specific DNA Binding Protein 1) • MIR3200 (MicroRNA 3200) • MMP3 (Matrix metallopeptidase 3)

KDR expression • DDB1 overexpression

over2years

miR-3200 accelerates the growth of liver cancer cells by enhancing Rab7A. (PubMed, Noncoding RNA Res)

Furthermore, our results suggest that miR-3200 enhances expression of RAB7A, and then Rab7A regulates the carcinogenic function of miR-3200 by increasing telomere remodeling in human liver cancer. These results are of great significance for the prevention and treatment of human liver cancer.

over 2 years ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • CCND1 (Cyclin D1) • SQSTM1 (Sequestosome 1) • PIM1 (Pim-1 Proto-Oncogene) • RAD54L (DNA Repair And Recombination Protein RAD54) • ARAF (A-Raf Proto-Oncogene) • PCNA (Proliferating cell nuclear antigen) • ANXA6 (Annexin A6) • CDK1 (Cyclin-dependent kinase 1) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • HOXC8 (Homeobox C8) • HSPA1A (Heat Shock Protein Family A (Hsp70) Member 1A) • MIR3200 (MicroRNA 3200) • PLK2 (Polo Like Kinase 2) • BECN1 (Beclin 1) • CDC45 (Cell Division Cycle 45) • FBXO32 (F-Box Protein 32) • FZD3 (Frizzled Class Receptor 3) • ITGB5 (Integrin Subunit Beta 5) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • PKM (Pyruvate Kinase M1/2) • RAB7A (RAB7A, Member RAS Oncogene Family) • SUV39H1 (SUV39H1 Histone Lysine Methyltransferase) • ABCE1 (ATP Binding Cassette Subfamily E Member 1)

over3years

Identification of a dysregulated ceRNA network modulated by copy number variation-driven lncRNAs in lung squamous cell carcinoma. (PubMed, Environ Mol Mutagen)

In summary, we devoted to analyzing CNV-related lncRNAs, mRNAs, and miRNAs in LUSC, thus clarifying 5 lncRNAs that may influence the malignant progression of LUSC. The ceRNA network regulated by these lncRNAs may be the novel pathogenesis of LUSC.

over 3 years ago

Journal

MIR96 (MicroRNA 96) • MIR1301 (MicroRNA 1301) • MIR143 (MicroRNA 143) • MIR3200 (MicroRNA 3200) • MIR205 (MicroRNA 205) • MIR22HG (MIR22 Host Gene) • MIR93 (MicroRNA 93)

over3years

Downregulation of HULC Induces Ferroptosis in Hepatocellular Carcinoma via Targeting of the miR-3200-5p/ATF4 Axis. (PubMed, Oxid Med Cell Longev)

HULC was found to function as a ceRNA of miR-3200-5p, and miR-3200-5p regulates ferroptosis by targeting ATF4, resulting in the inhibition of proliferation and metastasis within HCC cells. In summary, these findings illuminate some of the molecular mechanisms through which downregulation of HULC induces liver cancer cell ferroptosis by targeting the miR-3200-5p/ATF4 axis to modulate the development of hepatocellular carcinoma.

over 3 years ago

Journal

ATF4 (Activating Transcription Factor 4) • MIR3200 (MicroRNA 3200)

almost4years

MicroRNA-3200-3p targeting CAMK2A modulates the proliferation and metastasis of glioma in vitro. (PubMed, Bioengineered)

Importantly, these results further showed that miR-3200-3p downregulated the proliferation and metastasis by suppressing the expression of CAMK2A, thus regulating the Ras/Raf/MEK/ERK pathway. This study provided provided insights into the biological role of miR-3200-3p, which might function as a potential biomarker in glioma therapy.

almost 4 years ago

Preclinical • Journal

MIR3200 (MicroRNA 3200) • MIR320A (MicroRNA 320a) • CAMK2A (Calcium/Calmodulin Dependent Protein Kinase II Alpha)

over4years

LncRNA DARS-AS1 aggravates the growth and metastasis of hepatocellular carcinoma via regulating the miR-3200-5p-Cytoskeleton associated protein 2 (CKAP2) axis. (PubMed, Bioengineered)

miR-3200-5p exerted tumor-suppressive effects in HCC and inactivated CKAP2 and FAK-ERK pathway. All in all, this study corroborates that DARS-AS1 facilitates HCC proliferation and metastasis by regulating miR-3200-5p-mediated CKAP2, which provides a potential target for HCC diagnosis and treatment.

over 4 years ago

Journal

MIR3200 (MicroRNA 3200)

over4years

CircMTO1: A circular RNA with roles in the carcinogenesis. (PubMed, Biomed Pharmacother)

This circRNA can regulate activity of Notch, Wnt/β-Catenin, TGF-β/Smad, JAK1/STAT3 and AMPK signaling pathways. In the current study, we review the literature on the role of circMTO1 in the tumorigenesis.

over 4 years ago

Review • Journal

JAK1 (Janus Kinase 1) • TGFB1 (Transforming Growth Factor Beta 1) • MIR199A1 (MicroRNA 199a-1) • MIR221 (MicroRNA 221) • MIR17 (MicroRNA 17) • MIR3200 (MicroRNA 3200)

over4years

Risk Score Based on Two microRNAs as a Prognostic Marker of Hepatocellular Carcinoma and the Corresponding Competitive Endogenous RNA Network. (PubMed, Int J Gen Med)

We propose a risk score based on miR-3200-3p and miR-3690 that may be useful as a prognostic marker to predict HCC recurrence after LT. We generated a ceRNA network involving these miRNAs, which may help reveal their regulatory roles in HCC.

over 4 years ago

Journal

MIR3200 (MicroRNA 3200)

over4years

Plasma Exosomal miRNA Levels after Radiotherapy Are Associated with Early Progression and Metastasis of Cervical Cancer: A Pilot Study. (PubMed, J Clin Med)

LogFCs in the expression of miRNAs and mRNAs from plasma exosomes after CCRT are associated with EP and metastasis, reflecting unresolved inflammation and systemic microenvironmental factors, respectively. However, this study, supported by preliminary data insufficient to reach clear conclusions, should be verified in larger prospective cohorts.

over 4 years ago

Clinical • Journal

FCGR1A (Fc Fragment Of IgG Receptor Ia) • MIR3200 (MicroRNA 3200)

5years

The Search of miRNA Related to Invasive Growth of Nonfunctioning Gonadotropic Pituitary Tumors. (PubMed, Int J Endocrinol)

Unfortunately, differential expression of only hsa-miR-185-5p was confirmed in the validation cohort, with AUG at 0.654. Differences in miRNAs expression profiles in invasive and noninvasive gonadotropic PitNETs are slight and the level of miRNA expression seems not to be applicable as useful classifier of tumor invasiveness.

5 years ago

Journal

MIR184 (MicroRNA 184) • MIR3200 (MicroRNA 3200) • MIR320A (MicroRNA 320a) • miR-185 (MicroRNA 185) • MIR93 (MicroRNA 93)

over5years

Silencing of Long Noncoding RNA LINC00324 Interacts with MicroRNA-3200-5p to Attenuate the Tumorigenesis of Gastric Cancer via Regulating BCAT1. (PubMed, Gastroenterol Res Pract)

Furthermore, silencing of LINC00324 reversed the promoting effects of BCAT1 on the proliferation, migration, and invasion of GC cells. Silencing of LINC00324 inhibited the proliferation, migration, and invasion of GC cells through regulating the miR-3200-5p/BCAT1 axis.

over 5 years ago

Journal

BCAT1 (Branched Chain Amino Acid Transaminase 1 ) • MIR3200 (MicroRNA 3200) • MIR320A (MicroRNA 320a)

BCAT1 expression