^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR30B (MicroRNA 30b)

    i
    Other names: MIR30B, MicroRNA 30b, Hsa-MiR-30b-5p, Hsa-MiR-30b-3p, Hsa-Mir-30b, MIR30B, Hsa-Mir-30-P2c, MIMAT0000420, MIMAT0004589, MI0000441, MIRN30B, Mir-30b, RF00131
    3ms
    MicroRNAs in chemotherapy-induced peripheral neuropathy: mechanisms and therapies. (PubMed, Cell Cycle)
    Key miRNAs implicated in modulating these pathways are discussed in detail, including their potential as diagnostic biomarkers and therapeutic targets. By integrating molecular insights with translational approaches, this review provides a framework for future research and clinical applications targeting miRNA pathways to mitigate CIPN and improve outcomes for cancer patients undergoing chemotherapy.
    Review • Journal
    |
    MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR30B (MicroRNA 30b)
    3ms
    MicroRNA-Mediated Metabolic Control in HCC: From Molecular Networks to Therapy. (PubMed, Exp Cell Res)
    This study aims to elucidate the role of microRNAs in regulating metabolic pathways in HCC by delineating numerous miRNA-target interactions involved in glycolysis, lipid, amino acid, and nucleotide metabolism. This knowledge will enable us to identify novel diagnostic biomarkers and therapeutic targets for prognosis and to explore effective novel precision treatment strategies.
    Review • Journal
    |
    MIR21 (MicroRNA 21) • MIR27A (MicroRNA 27a) • MIR30B (MicroRNA 30b) • MIR122 (MicroRNA 122) • MIR148A (MicroRNA 148a)
    3ms
    Identification of anoikis-related genes and immune infiltration characteristics in Sjögren's syndrome based on machine learning. (PubMed, Front Med (Lausanne))
    These genes likely mediate their effects by influencing immune cell infiltration, participating in immune regulation, and modulating inflammatory responses. Our findings offer new insights into drug selection and immunotherapeutic strategies for SS.
    Journal • IO biomarker
    |
    CXCL10 (Chemokine (C-X-C motif) ligand 10) • BIRC3 (Baculoviral IAP repeat containing 3) • S100A9 (S100 Calcium Binding Protein A9) • MIR30B (MicroRNA 30b) • IFI27 (Interferon Alpha Inducible Protein 27) • IL15 (Interleukin 15) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1) • MAPK3 (Mitogen-Activated Protein Kinase 3) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR483 (MicroRNA 483) • MIR486-1 (MicroRNA 486-1)
    4ms
    Metabolic reprogramming in Helicobacter pylori infection: from mechanisms to therapeutics. (PubMed, Front Cell Infect Microbiol)
    These mechanisms collectively enable H. pylori to propel gastric carcinogenesis, highlighting metabolism-targeted interventions as future solutions. This review summarizes how H. pylori remodel the gastric microenvironment and drives pathogenesis by manipulating host lipid, glucose, lactate, and amino acid metabolism.
    Review • Journal
    |
    IL6 (Interleukin 6) • TGFB1 (Transforming Growth Factor Beta 1) • MIR30B (MicroRNA 30b) • APOA1 (Apolipoprotein A-I) • FABP1 (Fatty Acid Binding Protein 1)
    4ms
    Extracellular vesicle derived miRNAs from plasma as promising diagnosis and prognosis biomarkers for neuroblastoma. (PubMed, iScience)
    Functional analysis revealed involvement in key NB pathways. Our findings demonstrate that plasma sEV-derived miRNAs represent valuable noninvasive biomarkers for neuroblastoma diagnosis and risk stratification.
    Journal
    |
    MYCN (MYCN Proto-Oncogene BHLH Transcription Factor) • MIR142 (MicroRNA 142) • MIR30B (MicroRNA 30b) • MIR320A (MicroRNA 320a) • MIR150 (MicroRNA 150) • MIR342 (MicroRNA 342)
    4ms
    MicroRNAs and lung cancer: overview of essential pathways and somatic mutations in cancer progression. (PubMed, Front Oncol)
    Specifically, we highlight the modulatory roles of miRNA in cancer cell survival and proliferation (miR-28, miR-30b/c), invasion and metastasis (miR-218, miR-182), neoangiogenesis (miR-29c), metabolic reprogramming (miR-124), and therapy resistance (miR-378, miR-328, miR-1244). The broad implications of miRNAs in lung cancer underline their potential real-world utility, as these entities can function as biomarkers for prognosis/diagnosis and even future therapeutic targets or agents.
    Review • Journal
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • ALK (Anaplastic lymphoma kinase) • MET (MET proto-oncogene, receptor tyrosine kinase) • ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • MIR200C (MicroRNA 200c) • MIR30B (MicroRNA 30b) • NTRK (Neurotrophic receptor tyrosine kinase) • MIR182 (MicroRNA 182) • MIR328 (MicroRNA 328) • MIR218 (MicroRNA 218) • MIR22 (MicroRNA 22) • MIR33A (MicroRNA 33a)
    |
    KRAS mutation • EGFR mutation • KRAS G12C • BRAF mutation • ALK rearrangement • ROS1 fusion • ROS1 rearrangement • RET rearrangement • KRAS G12 • ALK translocation • NTRK fusion
    4ms
    Plasma exosomal miR-30b-5p attenuates neuroinflammation in a rat model of autism spectrum disorder. (PubMed, Front Psychiatry)
    Our study highlights that plasma exosomal miR-30b-5p attenuates neuroinflammation in a rat model of ASD by modulating EGFR through the MAPK signaling pathway and calcium signaling pathway. This study provides novel perspectives on plasma exosomal miR-30b-5p, which could be considered a potential therapeutic target for the treatment of ASD in the clinic.
    Preclinical • Journal
    |
    EGFR (Epidermal growth factor receptor) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • MIR30B (MicroRNA 30b) • IL1B (Interleukin 1, beta)
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    6ms
    A miR-30 Guided Molecular Profiling of Canine Osteosarcoma and Extraskeletal Osteosarcoma Reveals Non-Seed Regulatory Divergence. (PubMed, Cells)
    MiR-30a and miR-30e exhibited the highest diagnostic power (LR+ 7.7 and 6.8, respectively), supporting their role as biomarkers. These results highlight a miR-30-centered regulatory axis with relevance for diagnosis and molecular stratification of canine osteogenic tumors.
    Journal
    |
    MIR30B (MicroRNA 30b) • KPNA2 (Karyopherin Subunit Alpha 2) • MIR30A (MicroRNA 30a) • MIR30C • MIR30E (MicroRNA 30e) • RUNX2 (RUNX Family Transcription Factor 2)
    6ms
    RETRACTION: lncRNA PDCD4-AS1 Promotes the Progression of Glioma by Regulating miR-30b-3p/METTL7B Signaling. (PubMed, Oxid Med Cell Longev)
    [This retracts the article DOI: 10.1155/2023/3492480.].
    Journal
    |
    MIR30B (MicroRNA 30b)
    7ms
    Extracellular vesicle-encapsulated microRNA signatures of cigarette smoking and smoking-related harm. (PubMed, Respir Med)
    Recent cigarette smoking was associated with low miR-30b-5p expression in two distinct populations. Circulating miR-30b-5p is a robust biomarker of smoking-related harm and may represent a novel target for the prevention and treatment of smoking-related diseases.
    Journal
    |
    MIR30B (MicroRNA 30b)
    7ms
    LncRNA SNHG15 promotes proliferation, migration and invasion of lung adenocarcinoma cells by regulating COX6B1 through sponge adsorption of miR-30b-3p (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
    LncRNA SNHG15 may compete with COX6B1 to bind miR-30b-3p through a ceRNA mechanism to affect proliferation, migration, and invasion of lung adenocarcinoma cells.
    Journal
    |
    MIR30B (MicroRNA 30b) • SNHG5 (Small Nucleolar RNA Host Gene 5) • SNHG15 (Small Nucleolar RNA Host Gene 15)