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GENE:

MIR30A (MicroRNA 30a)

News alerts, weekly reports and conference planners

13d

Exosomal Cargo-Derived Mediators of Ovarian Cancer Chemoresistance. (PubMed, Mol Diagn Ther)

Overall, these findings highlight the multifaceted role of exosomes in ovarian cancer biology and underscore their potential as both biomarkers and therapeutic targets. A deeper understanding of how exosomes mediate molecular mechanisms may lead to novel strategies for overcoming chemoresistance and improving treatment outcomes for ovarian cancer patients.

13 days ago

Review • Journal

MIR21 (MicroRNA 21) • DNMT1 (DNA methyltransferase 1) • FOXP1 (Forkhead Box P1) • MIR1246 (MicroRNA 1246) • MIR30A (MicroRNA 30a) • MIR6836 (MicroRNA 6836) • PIP5K1A (Phosphatidylinositol-4-Phosphate 5-Kinase Type 1 Alpha)

29d

Bovine colostrum exosomes mediate anti-inflammatory responses in macrophages via the miR-30a-5p/Sox4 axis. (PubMed, J Dairy Sci)

The anti-inflammatory effect is mediated, at least in part, by the exosomal delivery of bta-miR-30a-5p and its subsequent targeting of Sox4 mRNA. These findings highlight early colostrum as a valuable source of therapeutic exosomes and elucidate a specific miRNA-mRNA axis for regulating inflammation.

29 days ago

Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • IL1B (Interleukin 1, beta) • MIR30A (MicroRNA 30a) • SOX4 (SRY-Box Transcription Factor 4)

DNA molecular subtraction controlled hybridization chain reaction for high contrast detecting and selective killing of cancer cells. (PubMed, Biosens Bioelectron)

The double-stranded DNA products further activate the cGAS-STING pathway, inducing selective immunogenic cytotoxicity in cancer cells while minimizing damage to normal cells. By integrating DNA molecular subtraction with enzyme-free amplification, SHCR establishes a differential-expression-responsive framework for high-contrast cancer cell discrimination and selective functional activation, providing a versatile strategy for precision nucleic acid-based theranostics.

1 month ago

Journal

MIR182 (MicroRNA 182) • MIR30A (MicroRNA 30a)

Extracellular Vesicles: A Multidimensional Role in the Occurrence and Development of Nasopharyngeal Carcinoma. (PubMed, Biomolecules)

Future research should focus on establishing the standardized production system and more convenient separation and purification techniques for EVs. This review provides a comprehensive overview of the nasopharyngeal carcinoma-related EVs.

1 month ago

Review • Journal

PTEN (Phosphatase and tensin homolog) • MIR30A (MicroRNA 30a)

2ms

Bioinformatics Identification and Functional Analysis of Key Genes of Nucleotide Metabolism in Oral Squamous Cell Carcinoma. (PubMed, Oral Health Prev Dent)

ADA, NT5E and TYMS can serve as potential diagnostic markers and therapeutic targets for OSCC. The study has reference value for early diagnosis and the development of individualised treatment strategies.

2 months ago

Journal

CD73 (5'-Nucleotidase Ecto) • TYMS (Thymidylate Synthetase) • NT5E (5'-Nucleotidase Ecto) • MIR192 (MicroRNA 192) • MIR30B (MicroRNA 30b) • MIR215 (MicroRNA 215) • MIR30A (MicroRNA 30a)

Ontak (denileukin diftitox) • Zanosar (streptozocin) • Mustargen (mechlorethamine)

2ms

Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))

Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.

2 months ago

Review • Journal

MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)

2ms

Apoptotic vesicles from endothelial cells promote endothelial progenitor cell differentiation and angiogenesis via miR-30a-5p mediated activation of the EGFR/PI3K/AKT/VEGF pathway. (PubMed, Stem Cell Res Ther)

EC-derived Apo-EVs demonstrated excellent capacity to promote EPCs differentiation and angiogenesis both in vitro and in vivo, the mechanism is associated with miR-30a-5p within the vesicles inhibiting PML and activating the EGFR/PI3K/AKT/VEGF signaling pathway. This finding provides a new perspective for revealing the role of EC-derived Apo-EVs in tissue repair and offers potential strategies for the treatment of related diseases.

2 months ago

Journal

MIR30A (MicroRNA 30a)

2ms

Exploring CSF microRNA signatures as diagnostic biomarkers in adult-type diffuse gliomas. (PubMed, Noncoding RNA Res)

Ingenuity Pathway Analysis (IPA) revealed that miR-16-5p and other miRNAs with seed AGCAGCA formed the largest interaction network in GBM, while disease enrichment analysis using Database for Annotation, Visualization, and Integrated Discovery (DAVID) confirmed that the 1000 predicted mRNA targets of DE-miRNAs in GBM were disease relevant. Collectively, these findings identify a robust panel of CSF-derived miRNAs capable of distinguishing IDH-mutant gliomas, GBM, and non-tumor states, supporting the potential of EV-miRNAs as minimally invasive biomarkers for the molecular characterization of diffuse gliomas.

2 months ago

Journal

IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • MIR21 (MicroRNA 21) • MIR142 (MicroRNA 142) • MIR16 (MicroRNA 16) • MIR19B1 (MicroRNA 19b-1) • MIR27B (MicroRNA 27b) • MIR99A (MicroRNA 99a) • MIR150 (MicroRNA 150) • MIR195 (MicroRNA 195) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a) • MIR30E (MicroRNA 30e)

IDH wild-type

3ms

Network-based insights into miR-30a-5p-mediated regulation and EGCG targeting in triple-negative breast cancer. (PubMed, Front Bioinform)

The results emphasizes that EGCG has strong binding affinity towards YWHAZ, revealing that miR-30a-EGCG targets TNBC synergistically through cell-cycle-mediated pathways. The findings give rational support for miRNA-guided phytochemical-based TNBC therapeutic development.

3 months ago

Journal

HER-2 (Human epidermal growth factor receptor 2) • PGR (Progesterone receptor) • PCNA (Proliferating cell nuclear antigen) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • CDC20 (Cell Division Cycle 20) • KIF11 (Kinesin Family Member 11) • ANLN (Anillin Actin Binding Protein) • CCNA1 (Cyclin A1) • MIR30A (MicroRNA 30a) • SKP2 (S-phase kinase-associated protein 2) • YWHAZ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Zeta)

HER-2 expression

3ms

miRNA as a Prognostic Marker in Small Lung Cell Carcinoma. (PubMed, Genes (Basel))

In particular, strategies that restore or inhibit miRNA activity using mimics or antagomiRs show promise in improving drug sensitivity and complementing current treatment options. Overall, emerging evidence supports the integration of miRNA profiling into precision oncology for SCLC, with the aim of refining diagnosis, risk assessment and therapeutic decision-making.

3 months ago

Review • Journal • PARP Biomarker

PARP1 (Poly(ADP-Ribose) Polymerase 1) • MIR200B (MicroRNA 200b) • TGFB1 (Transforming Growth Factor Beta 1) • MIR100 (MicroRNA 100) • MIR7 (MicroRNA 7) • MIR335 (MicroRNA 335) • MIR494 (MicroRNA 494) • MIR495 (MicroRNA 495) • MIR181B1 (MicroRNA 181b-1) • MIR22 (MicroRNA 22) • MIR30A (MicroRNA 30a) • MIR134 (MicroRNA 134)

4ms

Serum miRNA and Metabolomic Signatures of Residential Radon Exposure in Chiang Mai, Thailand. (PubMed, Toxics)

Given the small sample size (n = 10), these findings should be interpreted as preliminary and hypothesis-generating, warranting validation in larger cohorts. Nevertheless, findings support household testing, remediation at ≥100 Bq/m3, and integrated exposure studies considering PM2.5 co-exposures.

4 months ago

Journal • Metabolomic study

MIR200B (MicroRNA 200b) • MIR200C (MicroRNA 200c) • MIR584 (MicroRNA 584) • MIR125A (MicroRNA 125a) • MIR194 (MicroRNA 194) • MIR22 (MicroRNA 22) • MIR30A (MicroRNA 30a)