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    GENE:

    MIR2277 (MicroRNA 2277)

    i
    Other names: MIR227, MicroRNA 2277, Hsa-Mir-2277, Hsa-MiR-2277-3p, MIR2277, Hsa-MiR-2277-5p, MIMAT0011777, MIMAT0017352, MI0011284, Mir-2277
    5ms
    Extrachromosomal circular DNA expressing miRNA promotes ovarian cancer progression. (PubMed, Clin Transl Med)
    This study revealed a 13-fold increase of eccDNA in HGSOC compared to normal tissues, with significant enrichment in promoter and coding regions. eccDNA-derived miRNAs (eccMIRs) were shown to enhance cancer cell proliferation, invasion, and tumor growth through the expression of oncogenic miRNA sequences. The study highlights the importance of the MMEJ pathway in eccDNA generation and proposes that targeting eccDNA biogenesis in this aggressive malignancy presents a novel therapeutic opportunity.
    Journal
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    MIR2277 (MicroRNA 2277) • LIG3 (DNA Ligase 3)
    almost2years
    Visfatin Facilitates VEGF-D-Induced Lymphangiogenesis through Activating HIF-1α and Suppressing miR-2277-3p in Human Chondrosarcoma. (PubMed, Int J Mol Sci)
    Importantly, visfatin controls chondrosarcoma-related lymphangiogenesis in vivo. Therefore, visfatin is a promising target in the treatment of chondrosarcoma lymphangiogenesis.
    Journal
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    HIF1A (Hypoxia inducible factor 1, alpha subunit) • VEGFD (Vascular Endothelial Growth Factor D) • MIR2277 (MicroRNA 2277) • NAMPT (Nicotinamide Phosphoribosyltransferase)
    almost2years
    Identification of a hypoxia-suppressed lncRNA RAMP2-AS1 in breast cancer. (PubMed, Noncoding RNA Res)
    Intriguingly, in vitro experiments confirmed that RAMP2-AS1 was a hypoxia-suppressed lncRNA and miR-660-5p/ATM was a potential downstream axis of RAMP2-AS1 in breast cancer. Collectively, our current data elucidated a key hypoxia-suppressed lncRNA RAMP2-AS1 and its possible miRNA-mRNA regulatory mechanism in breast cancer.
    Journal
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    ATM (ATM serine/threonine kinase) • MIR1301 (MicroRNA 1301) • MIR2277 (MicroRNA 2277) • MIR660 (MicroRNA 660)