^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    MIR217 (MicroRNA 217)

    i
    Other names: MIR217, MicroRNA 217, Hsa-Mir-217, Hsa-MiR-217, MIMAT0000274, MIMAT0037308, MI0000293, MIRN217, Mir-217, MiR-217, RF00673
    Associations

    News

    Trials
    4d
    [Retracted] MicroRNA 217 inhibits cell proliferation and enhances chemosensitivity to doxorubicin in acute myeloid leukemia by targeting KRAS. (PubMed, Oncol Lett)
    [This retracts the article DOI: 10.3892/ol.2017.6076.].
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • MIR217 (MicroRNA 217)
    |
    doxorubicin hydrochloride
    2ms
    Nerofe+ldDox releases c-Jun from nuclear ST2 to reprogram the immune microenvironment in mtKRAS tumors. (PubMed, Oncotarget)
    Nerofe+ldDox reprograms the immune microenvironment of mtKRAS tumors by releasing c-Jun from inhibitory nuclear ST2, enabling expression of IL-2 and miR-217. This "nuclear immunomodulation" promotes immune cell infiltration and downregulates KRAS expression, highlighting Nerofe+ldDox as a promising therapeutic approach for mtKRAS-driven cancers.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • IL10 (Interleukin 10) • TGFB1 (Transforming Growth Factor Beta 1) • JUN (Jun proto-oncogene) • MIR217 (MicroRNA 217) • ST2 (Suppression Of Tumorigenicity)
    |
    KRAS mutation
    |
    doxorubicin hydrochloride • Nerofe (84AA-API 14AA)
    2ms
    Basic Science and Pathogenesis. (PubMed, Alzheimers Dement)
    Collectively, our data establish 1) an in vitro model to test PSEN2 3'UTR isoforms, 2) miRNA expression differences in human AD synaptosome and homogenate fractions, and 3) decreased PSEN2 transcript signal in human AD frontal cortex tissue. Elucidating the functional significance of PSEN2 3'UTR isoform regulation will further our understanding of AD.
    Journal
    |
    MIR217 (MicroRNA 217) • MIR326 (MicroRNA 326)
    3ms
    Quercetin Inhibits Gastric Cancer Progression via Suppression of HOTAIR/mir-217/GPC5 Axis. (PubMed, Iran J Pharm Res)
    These findings highlight QCT's ability to inhibit GC progression via the HOTAIR/miR-217/GPC5 axis, with molecular heterogeneity influencing therapeutic response. The QCT emerges as a promising candidate for further investigation as a multifaceted agent against GC, though validation in preclinical models is necessary.
    Journal
    |
    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • HOTAIR (HOX Transcript Antisense RNA) • ANXA5 (Annexin A5) • MIR217 (MicroRNA 217)
    4ms
    Circular RNA hsa_circ_0006522 correlates with unfavorable prognosis and promotes the proliferative, migrative, and invasive abilities of breast cancer cells. (PubMed, Transl Cancer Res)
    Specifically, hsa_circ_0006522 could notably enhance the proliferation, migration, and invasion of breast cancer cells. Based on these findings, we hypothesized that hsa_circ_0006522 is highly probable to be a vital biomarker in breast cancer progression.
    Journal
    |
    MIR769 (MicroRNA 769) • MIR217 (MicroRNA 217)
    5ms
    Diagnostic and prognostic potential of microRNA profiles in endometrioid endometrial cancer. (PubMed, Sci Rep)
    We showed that miRNAs have good diagnostic sensitivity for identifying EEC and EC grading. In addition, miRNA improved the ability to discriminate between ECs of different grades.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • PTEN (Phosphatase and tensin homolog) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR200B (MicroRNA 200b) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR429 (MicroRNA 429) • MIR30B (MicroRNA 30b) • MIR324 (MicroRNA 324) • MIR543 (MicroRNA 543) • MIR96 (MicroRNA 96) • Let-7c (MicroRNA Let-7c) • MIR126 (MicroRNA 126) • MIR141 (MicroRNA 141) • MIR182 (MicroRNA 182) • MIR18A (MicroRNA 18a) • MIR129 (MicroRNA 129) • MIR129-2 (MicroRNA 129-2) • MIR130A (MicroRNA 130a) • MIR181B1 (MicroRNA 181b-1) • MIR183 (MicroRNA 183) • MIR203A (MicroRNA 203a) • MIR205 (MicroRNA 205) • MIR217 (MicroRNA 217) • MIR30C • MIRLET7E (MicroRNA Let-7e)
    6ms
    Epigenetic regulation of breast ductal carcinoma in situ by miR-217 through DNMT1 and Hedgehog-GLI pathway. (PubMed, J Cell Commun Signal)
    The miR-217/DNMT1/TSHZ2/Hedgehog-GLI signaling axis modulates DCIS progression by epigenetically reprogramming oncogenic pathways. Targeting this axis may offer a promising strategy for DCIS treatment.
    Journal
    |
    GLI1 (GLI Family Zinc Finger 1) • DNMT1 (DNA methyltransferase 1) • MIR217 (MicroRNA 217)
    6ms
    Prognostic role and functional impact of cadherin genes in non-small cell lung cancer tumorigenesis: mechanistic insights from in silico and in vitro analyses. (PubMed, PeerJ)
    The results of functional assays indicate that the silencing of CDH1 and CDH2 inhibits cell proliferation, colony formation, and migration in A549 cells, highlighting their potential roles in promoting tumorigenic and migratory properties in NSCLC. Collectively, our findings suggest that cadherin family genes (CDH1, CDH2, and CDH3) play critical roles in NSCLC tumorigenesis and progression, highlighting their significance as diagnostic markers.
    Preclinical • Journal
    |
    CDH1 (Cadherin 1) • CDH2 (Cadherin 2) • CDH3 (Cadherin 3) • MIR203A (MicroRNA 203a) • MIR217 (MicroRNA 217)
    6ms
    Case Report: Locally advanced lung adenocarcinoma with a novel MIR217HG-ALK rearrangement responding to neoadjuvant alectinib. (PubMed, Front Pharmacol)
    In this study, we present the first documented case of a patient with lung adenocarcinoma harboring a novel MIR217HG-ALK rearrangement who exhibited favorable response to neoadjuvant alectinib. Our findings suggest that alectinib holds promise as an efficacious therapeutic option for individuals with MIR217HG-ALK rearranged lung adenocarcinoma, thereby offering valuable insights for the clinical management of these patients.
    Journal
    |
    ALK (Anaplastic lymphoma kinase) • MIR217 (MicroRNA 217)
    |
    ALK rearrangement
    |
    Vysis ALK Break Apart FISH Probe Kit
    |
    Alecensa (alectinib)
    10ms
    Exploring the Functional and Prognostic Significance of miR-217 in Uterine Corpus Endometrial Carcinoma. (PubMed, Curr Med Chem)
    The up-regulation of miR-217 is strongly linked to an adverse prognosis in UCEC patients, suggesting its potential as a prognostic biomarker and a predictor of immunotherapy response in UCEC patients.
    Journal • IO biomarker
    |
    BCL2 (B-cell CLL/lymphoma 2) • MIR217 (MicroRNA 217)
    10ms
    Evaluation of specific lncRNAs, miRNAs, and mRNAs in different groups of prostate cancer. (PubMed, Bioimpacts)
    Our results identified promising biomarkers that play a role in specific groups of prostate cancer patients. Detecting specific biomarkers may be an effective strategy for different groups of PC patients.
    Journal
    |
    CDH1 (Cadherin 1) • CD24 (CD24 Molecule) • GNAS (GNAS Complex Locus) • MIR152 (MicroRNA 152) • MIR27B (MicroRNA 27b) • MIR375 (MicroRNA 375) • ST14 (ST14 transmembrane serine protease matriptase) • LINC01128 (Long Intergenic Non-Protein Coding RNA 1128) • MIR203A (MicroRNA 203a) • MIR217 (MicroRNA 217) • MIR876 (MicroRNA 876) • LINC00857 (Long Intergenic Non-Protein Coding RNA 857)
    11ms
    [Retracted] miR‑217 inhibits the migration and invasion of HeLa cells through modulating MAPK1. (PubMed, Int J Mol Med)
    The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 44: 1824‑1832, 2019; DOI: 10.3892/ijmm.2019.4328].
    Journal
    |
    MAPK1 (Mitogen-activated protein kinase 1) • GAPDH (Glyceraldehyde-3-Phosphate Dehydrogenase) • MIR217 (MicroRNA 217)