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    GENE:

    MIR215 (MicroRNA 215)

    i
    Other names: MIR215, MicroRNA 215, Hsa-MiR-215-5p, Hsa-Mir-215, MIRN215, Hsa-Mir-192-P2, Hsa-MiR-215-3p, MIMAT0000272, MIMAT0026476, MI0000291, MiRNA215, Mir-215, RF00130
    Associations

    News

    Trials
    27d
    Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers. (PubMed, Toxics)
    ROC curve analysis showed that both miRNAs demonstrated good diagnostic efficacy for pneumoconiosis, with AUC values of 0.9563 and 0.8876, respectively. These results provide novel insights into the complex ceRNA regulatory network involved in silicosis pathogenesis and suggest potential early, non-invasive diagnostic biomarkers.
    Journal
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    TNFA (Tumor Necrosis Factor-Alpha) • MIR485 (MicroRNA 485) • MIR146B (MicroRNA 146b) • MIR215 (MicroRNA 215)
    6ms
    The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Factors in Colorectal Cancer. (PubMed, Cancers (Basel))
    Selected lncRNAs, including THOR and LINC01094, have also demonstrated significant prognostic value. Despite these advances, challenges persist, including inconsistent reporting, limited external validation, and a lack of replication by independent research groups.
    Review • Journal
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    ERCC1 (Excision repair cross-complementation group 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR21 (MicroRNA 21) • GAS6 (Growth arrest specific 6) • MIR211 (MicroRNA 211) • IGFBP3 (Insulin-like growth factor binding protein 3) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR140 (MicroRNA 140) • MIR150 (MicroRNA 150) • MIR215 (MicroRNA 215) • MIR675 (MicroRNA 675) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SNHG14 (Small Nucleolar RNA Host Gene 14) • ASB16-AS1 (ASB16 Antisense RNA 1)
    6ms
    Deciphering molecular overlaps between COPD and NSCLC subtypes (LUAD and LUSC): An integrative bioinformatics study. (PubMed, Medicine (Baltimore))
    Drug-gene interaction analysis identified Marimastat, Bosentan, and Minocycline as potential therapeutic agents that target key molecular pathways shared across COPD, LUAD and LUSC. This study represents the initial effort to map TF-miRNA-DEG-drug networks across COPD and both the LUAD and LUSC subtypes. These results suggest potential biomarkers for early diagnosis and highlight opportunities for drug repurposing to mitigate COPD-associated lung cancer risk.
    Journal
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    SPP1 (Secreted Phosphoprotein 1) • MIR192 (MicroRNA 192) • MIR335 (MicroRNA 335) • MMP11 (Matrix Metallopeptidase 11) • MIR215 (MicroRNA 215) • POSTN (Periostin)
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    minocycline
    6ms
    Dysregulated miRNAs Targeting Adiponectin Signaling in Colorectal Cancer. (PubMed, Int J Mol Sci)
    Through gene ontology enrichment analysis, we further elucidated the biological processes and pathways impacted by these miRNAs, providing insight into their contributions to CRC. The literature review did not identify any previously reported shared connection between these miRNAs, adiponectin signaling, and CRC pathogenesis.
    Journal
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    MIR21 (MicroRNA 21) • MIR96 (MicroRNA 96) • MIR340 (MicroRNA 340) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR19A (MicroRNA 19a) • MIR215 (MicroRNA 215)
    8ms
    Tumor Suppressor miRNA-based Signatures in Triple Negative Breast Cancer: A Study Based on Big Data Analysis of Gene Expression Omnibus (GEO) Datasets and Its Validation. (PubMed, Asian Pac J Cancer Prev)
    miR-204 can be a potential therapeutic molecule in TNBC. Strategies aimed at restoring the expression of miR-204 through miRNA replacement therapies could offer novel therapeutic approaches for TNBC patients.
    Journal
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    MIR139 (MicroRNA 139) • MIR204 (MicroRNA 204) • MIR215 (MicroRNA 215) • MIR26A1 (MicroRNA 26a-1)
    11ms
    CXCR2P1 enhances the response of gastric cancer to PD-1 inhibitors through increasing the immune infiltration of tumors. (PubMed, Front Immunol)
    It reshapes the immune microenvironment by increasing immune infiltration and changing the fraction of immune cells. In tumor immune microenvironment, CXCR2P1 can promote inflammation, enhance antigen presentation and activate the PD-1/PD-L1-related signaling pathway, which might be achieved by CXCR2P1-MIR215 axis.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • CD4 (CD4 Molecule) • MIR215 (MicroRNA 215)
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    PD-L1 expression
    11ms
    miRNAs-Set of Plasmatic Extracellular Vesicles as Novel Biomarkers for Hepatocellular Carcinoma Diagnosis Across Tumor Stage and Etiologies. (PubMed, Int J Mol Sci)
    Individually and as a panel, they demonstrated high sensitivity, specificity, and accuracy in identifying HCC patients. Their consistent upregulation across models and clinical samples highlights their robustness as biomarkers for HCC diagnosis, offering the potential for early disease management and prognosis.
    Journal
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    MIR34A (MicroRNA 34a-5p) • MIR148B (MicroRNA 148b) • MIR183 (MicroRNA 183) • MIR19A (MicroRNA 19a) • MIR215 (MicroRNA 215)
    11ms
    Glycolysis-related lncRNA FTX upregulates YAP1 to facilitate colorectal cancer progression via sponging miR-215-3p. (PubMed, Sci Rep)
    Additionally, a negative correlation was observed between lncRNA FTX and miR-215-3p expression, and the knockdown of lncRNA FTX or miR-215-3p overexpression yielded opposite effects. In conclusion, this study demonstrates that FTX could directly combine with miR-215-3p as a competitive endogenous RNA, thus promoting the aerobic glycolysis and progression of CRC in vitro and in vivo.
    Journal
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    YAP1 (Yes associated protein 1) • MIR215 (MicroRNA 215)
    over1year
    Targeted Microglial Membrane-Coated MicroRNA Nanosponge Mediates Inhibition of Glioblastoma. (PubMed, ACS Nano)
    The BM@miR-nanosponge notably extended the median survival time of GBM-bearing mice and outperformed the standard treatment drug temozolomide (TMZ). This study introduces a comprehensive miR-based strategy for GBM treatment and highlights the importance of targeting multiple miRs associated with tumor survival for effective therapy.
    Journal
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    MIR21 (MicroRNA 21) • MIR221 (MicroRNA 221) • MIR215 (MicroRNA 215)
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    temozolomide
    over1year
    DDP Induced Cytotoxicity through miR-215-5p/COL5A1/FSTL1 Axis to Regulate Autophagy in Lung Adenocarcinoma Cells. (PubMed, Curr Pharm Biotechnol)
    The present study demonstrated that miR-215-5p regulated COL5A1 to modulate FSTL1 and autophagy, thereby attenuating LUAD resistance to DDP. These findings deepen the understanding of LUAD pathogenesis and provide potential insights into therapeutic strategies.
    Journal
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    COL5A1 (Collagen Type V Alpha 1 Chain) • FSTL1 (Follistatin Like 1) • MIR215 (MicroRNA 215)
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    cisplatin
    over1year
    CircRNA hsa_circ_0003528/miR-215 is considered a potential target for predictive prognosis and therapy for triple-negative breast cancer. (PubMed, Mol Biol Rep)
    hsa_circ_0003528 is upregulated in TNBC and can facilitate aggressive cellular behaviors by regulating miR-215 expression, hinting at its potential as a biomarker and therapeutic target in the treatment of TNBC.
    Journal
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    MIR215 (MicroRNA 215)