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GENE:

MIR214 (MicroRNA 214)

News alerts, weekly reports and conference planners

11d

Engineered extracellular vesicles enriched with the miR-214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer. (PubMed, Mol Oncol)

m214-sEV treatment reprograms secondary tumor-derived sEVs toward a less prometastatic cargo profile and decreases carboplatin resistance and cell migration. Enforced YKT6 overexpression abrogates these effects, establishing YKT6 as a key downstream effector. Collectively, these findings support engineered sEVs as a translatable strategy to overcome chemoresistance and disrupt pro-tumorigenic EV signaling in recurrent OC.

11 days ago

Journal • IO biomarker

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TLR4 (Toll Like Receptor 4) • MIR199A (MicroRNA 199a) • MIR214 (MicroRNA 214)

carboplatin

14d

Prognostic value of CCDC18-AS1 in gastric cancer and its regulatory effect on tumor progression. (PubMed, Biomark Med)

CCDC18-AS1 is overexpressed in GC and independently predicts poor prognosis. It promotes GC progression by targeting miR-214-3p, thereby regulating key oncogenic processes.

14 days ago

Journal

BCL2 (B-cell CLL/lymphoma 2) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • CCNB1 (Cyclin B1) • MIR214 (MicroRNA 214)

15d

Profiles of microRNAs in Patients with Advanced Breast Cancer Who are Chemoresistant or Chemosensitive to Fluorouracil, Adriamycin, and Cyclophosphamide Treatment. (PubMed, Asian Pac J Cancer Prev)

Therefore, these findings suggest that miRNAs may serve as predictive biomarkers and potential therapeutic targets in the management of breast cancer.

15 days ago

Journal

MIR152 (MicroRNA 152) • MIR27A (MicroRNA 27a) • MIR424 (MicroRNA 424) • MIR195 (MicroRNA 195) • MIR20A (MicroRNA 20a) • MIR214 (MicroRNA 214) • MIR222 (MicroRNA 222) • MIRLET7E (MicroRNA Let-7e)

5-fluorouracil • doxorubicin hydrochloride • cyclophosphamide

Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)

The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.

1 month ago

Journal

TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)

2ms

Long noncoding RNA HNF1A-AS1 promotes ovarian cancer growth and M2 macrophage polarization by counteracting miR-214-mediated suppression of semaphorin 4D signaling. (PubMed, Acta Biochim Biophys Sin (Shanghai))

Our study suggests that by antagonizing miR-214, HNF1A-AS1 activates the SEMA4D/PLEXIN-B1/TIAM/RAC pathway, facilitating EOC growth and potentially promoting M2 macrophage polarization in the tumor microenvironment. HNF1A-AS1 represents a compelling therapeutic target for treating EOC.

2 months ago

Journal

TIAM1 (TIAM Rac1 Associated GEF 1) • HNF1A (HNF1 Homeobox A) • MIR214 (MicroRNA 214) • SEMA4D (Semaphorin 4D)

2ms

Coxsackievirus B3 suppresses oral squamous cell carcinoma by inducing ferroptosis through the circ_0010074/miR-214-3p/GPX4 pathway. (PubMed, Life Sci)

Our research demonstrates that CVB3 acts as a highly effective oncolytic virus in targeting OSCC, inducing ferroptosis via the previously unrecognized circ_0010074/miR-214-3p/GPX4 pathway. This discovery opens new doors for treating this particularly aggressive form of cancer, offering a potentially groundbreaking therapeutic approach.

2 months ago

Journal • IO biomarker

GPX4 (Glutathione Peroxidase 4) • MIR214 (MicroRNA 214)

2ms

Novel MicroRNA Biomarkers Revealed in the Serum and Bile of Thioacetamide Induced Cholangiocarcinoma. (PubMed, Chem Biol Interact)

Therefore, those miRNAs have the potential to serve as early and sensitive biomarkers for TAA-induced cholangiocarcinoma. Notably, no previous study has demonstrated the role of miR-146-5p on cancer development.

2 months ago

Journal

MIR223 (MicroRNA 223) • MIR146B (MicroRNA 146b) • MIR214 (MicroRNA 214)

2ms

Non-Coding RNAs and Liquid Biopsies: Emerging Biomarkers for Cervical Cancer. (PubMed, Crit Rev Oncol Hematol)

Thus, in this comprehensive narrative review, we map the range of candidate ncRNAs reported in the literature and discuss their predictive, diagnostic, prognostic and therapeutic value, including their potential as circulating biomarkers in CC. We also highlight, as a future perspective, how integrated profiling approaches could guide research and support the development of non-invasive strategies for diagnosis, prognostic assessment, and therapy monitoring in CC.

2 months ago

Review • Journal • Liquid biopsy

MIR21 (MicroRNA 21) • HOTAIR (HOX Transcript Antisense RNA) • PVT1 (Pvt1 Oncogene) • MIR20A (MicroRNA 20a) • MIR214 (MicroRNA 214) • MIR218 (MicroRNA 218)

3ms

Ursolic acid induces colorectal cancer cells ferroptosis via regulation of system xc- and miR-214-3p/Stat3/GPX4 axis. (PubMed, Front Immunol)

According to in vivo experiments, UA inhibited CRC tumor growth by regulation of above genes. This study demonstrated that UA could effectively inhibit CRC proliferation by inducing ferroptosis via regulation of system xc- subunits and miR-214-3p/Stat3/GPX4 axis, suggesting UA could serve as a promising anti-colorectal cancer candidate requiring further validation and optimization.

3 months ago

Journal

STAT3 (Signal Transducer And Activator Of Transcription 3) • SLC3A2 (Solute Carrier Family 3 Member 2) • GPX4 (Glutathione Peroxidase 4) • SLC7A11 (Solute Carrier Family 7 Member 11) • MIR214 (MicroRNA 214)

3ms

Comprehensive long-read transcriptomic analysis reveals multi-level transcriptional alterations mediated by miR-214-3p dysregulation in gastric cancer cells. (PubMed, BMC Cancer)

Collectively, these findings highlight the potential multifaceted regulatory roles of miR-214-3p in mediating proliferation and apoptosis through diverse mechanisms in AGS gastric cancer cells, thereby advancing our understanding of its critical role in gastric cancer progression and its therapeutic potential.

3 months ago

Journal

MIR214 (MicroRNA 214)

3ms

Circulating levels of microRNAs 126-5p, 150-5p, 214-3p, and 452-5p decrease following splenectomy in dogs with hemangiosarcoma. (PubMed, Am J Vet Res)

MiR-126-5p, miR-150-5p, miR-214-3p, and miR-452-5p all showed a decrease in expression at at least one timepoint following splenectomy. These miRNAs have been previously shown to have roles in angiogenesis and pathways known to be involved in the pathogenesis of hemangiosarcoma and may be prospective targets for a minimally invasive diagnostic panel for the presence of splenic hemangiosarcoma.

3 months ago

Journal

MIR543 (MicroRNA 543) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR494 (MicroRNA 494) • MIR497 (MicroRNA 497) • MIR150 (MicroRNA 150) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIR93 (MicroRNA 93)

3ms

A panel of 4 circulating microRNAs (126-5p, 150-5p, 452-5p, and 543) discriminates dogs with splenic hemangiosarcoma from those with noncancerous splenic masses. (PubMed, Am J Vet Res)

If a mass is not hemangiosarcoma, owners may be more likely to proceed with surgery rather than euthanasia. Knowing that a mass is hemangiosarcoma will provide information to owners on the need for adjuvant therapy following surgery.

3 months ago

Journal