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    GENE:

    MIR211 (MicroRNA 211)

    i
    Other names: MIR211, MicroRNA 211, Hsa-MiR-211-5p, Hsa-Mir-211, Hsa-Mir-204-P2, MIRN211
    2ms
    CircAMOTL1 promotes adipose lipolysis and browning in cancer cachexia through miR-211-5p-mediated TET2 activation. (PubMed, J Biol Chem)
    By modulating the circAMOTL1/miR-211-5p/TET2 axis, it drives lipolysis and thermogenic reprogramming of white adipose tissue. circAMOTL1 therefore represents a promising biomarker and a potential therapeutic target for preventing or attenuating cachexia-associated adipose tissue loss.
    Journal
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    TET2 (Tet Methylcytosine Dioxygenase 2) • MIR211 (MicroRNA 211)
    5ms
    Targeting FOXK2 in triple-negative breast cancer: Role of the P53/MCAS1/miR-211-5p regulatory axis. (PubMed, Funct Integr Genomics)
    Clinical samples from TNBC patients further confirmed a correlation between FOXK2 expression and tumor size, lymphatic involvement, as well as the expression level of Ki-67. Our findings unveil a novel P53/MCAS1/miR-211-5p/FOXK2 regulatory axis that dictates TNBC aggressiveness. FOXK2 may sever as both a prognostic biomarker and a therapeutic target in TNBC.
    Journal
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    MIR211 (MicroRNA 211)
    6ms
    The Multifaceted Role of miR-211 in Health and Disease. (PubMed, Biomolecules)
    The review also explores miR-211's therapeutic potential, discussing both challenges and opportunities in developing miRNA-based treatments. Understanding miR-211's complex regulatory interactions and context-dependent functions is crucial for advancing its clinical applications for diagnosis, prognosis, and targeted therapy in multiple diseases.
    Review • Journal
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    TGFB1 (Transforming Growth Factor Beta 1) • MIR211 (MicroRNA 211)
    6ms
    The Role of Epigenetic Biomarkers as Diagnostic, Predictive and Prognostic Factors in Colorectal Cancer. (PubMed, Cancers (Basel))
    Selected lncRNAs, including THOR and LINC01094, have also demonstrated significant prognostic value. Despite these advances, challenges persist, including inconsistent reporting, limited external validation, and a lack of replication by independent research groups.
    Review • Journal
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    ERCC1 (Excision repair cross-complementation group 1) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • MIR21 (MicroRNA 21) • GAS6 (Growth arrest specific 6) • MIR211 (MicroRNA 211) • IGFBP3 (Insulin-like growth factor binding protein 3) • LINC01094 (Long Intergenic Non-Protein Coding RNA 1094) • MIR140 (MicroRNA 140) • MIR150 (MicroRNA 150) • MIR215 (MicroRNA 215) • MIR675 (MicroRNA 675) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SNHG14 (Small Nucleolar RNA Host Gene 14) • ASB16-AS1 (ASB16 Antisense RNA 1)
    7ms
    Molecular and Genetic Pathogenesis of Oral Cancer: A Basis for Customized Diagnosis and Treatment. (PubMed, Biology (Basel))
    The knowledge of this molecular pathogenesis has not yet been translated into clinical practice, apart from the use of cetuximab, an EGFR antibody...Liquid biopsies, either resorting to circulating tumor cells, extracellular vesicles or cell-free nucleic acids, have the potential to bypass this problem, and have potential prognostic and staging value. We critically review the current knowledge on the molecular, genetic and epigenetic alterations in oral cancer, as well as the applications and challenges of liquid biopsies in its diagnosis, follow-up, and prognostic stratification.
    Review • Journal
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    TP53 (Tumor protein P53) • PTEN (Phosphatase and tensin homolog) • HRAS (Harvey rat sarcoma viral oncogene homolog) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • CCND1 (Cyclin D1) • CDH1 (Cadherin 1) • FAT1 (FAT atypical cadherin 1) • ADAM9 (ADAM Metallopeptidase Domain 9) • MIR21 (MicroRNA 21) • MGAM (Maltase-Glucoamylase) • SOX17 (SRY-Box Transcription Factor 17) • MIR100 (MicroRNA 100) • MIR211 (MicroRNA 211) • MIR221 (MicroRNA 221) • MIR184 (MicroRNA 184) • MIR31 (MicroRNA 31) • MIR375 (MicroRNA 375) • CTTN (Cortactin) • MIR133B (MicroRNA 133b) • MIR138 (MicroRNA 138) • MIR200 (MicroRNA 200) • MIR203A (MicroRNA 203a) • MIR222 (MicroRNA 222)
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    Erbitux (cetuximab)
    8ms
    RNFT2 promotes malignancy of triple-negative breast cancer and predicts poor outcomes. (PubMed, J Mol Histol)
    Meanwhile, animal experimental data further implied that RNFT2 knockdown reduced TNBC cell proliferation in vivo. RNFT2 facilitated TNBC development and predicted its adverse outcomes.
    Journal
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    MIR211 (MicroRNA 211)
    9ms
    The Molecular Mechanism by Which miR-211-5p Regulates the Proliferation and Differentiation of Preadipocytes in Meat Rabbits by Targeting TPK1. (PubMed, Animals (Basel))
    (5) After co-transfection of miR-211-5p inhibitor and si-TPK1, experiments such as EdU assay, RT-qPCR, western blot (WB), Oil Red O staining, and CCK-8 cell viability detection were conducted. It was found that miR-211-5p inhibits the proliferation and promotes the differentiation of rabbit preadipocytes by targeting TPK1.
    Preclinical • Journal
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    MIR211 (MicroRNA 211)
    10ms
    Identification of Common miRNAs Differentially Expressed in Periodontitis and Pancreatic Cancer. (PubMed, In Vivo)
    Our study suggests candidate molecular mechanisms linking periodontitis to pancreatic cancer, highlighting potential compounds that may target both diseases. These findings provide a foundation for guiding future fundamental and clinical research.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BCR (BCR Activator Of RhoGEF And GTPase) • AKT1 (V-akt murine thymoma viral oncogene homolog 1) • CCND1 (Cyclin D1) • BCL6 (B-cell CLL/lymphoma 6) • MIR155 (MicroRNA 155) • MIR211 (MicroRNA 211) • AGO2 (Argonaute RISC Catalytic Component 2) • MIR186 (MicroRNA 186) • MIR375 (MicroRNA 375) • TXNIP (Thioredoxin Interacting Protein) • SOD2 (Superoxide Dismutase 2)
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    gemcitabine • 5-fluorouracil • temozolomide • doxorubicin hydrochloride
    10ms
    Sevoflurane: A dual modulator of miR‑211‑5p and mitochondrial apoptosis in glioma therapy. (PubMed, Mol Med Rep)
    Collectively, SEV promoted apoptosis in glioma cells by inducing miR‑211‑5p, which regulated SIRT1/PI3K/AKT pathway, mediating mitochondria‑dependent apoptosis pathway. This finding may open new possibilities for SEV as a potential treatment for glioma in the future.
    Journal
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    MIR211 (MicroRNA 211)
    10ms
    Tumor-Derived Exosomes Enriched by miRNA-211a Promote Antitumor Immune Response in B16F10 Tumor-Bearing Mice. (PubMed, APMIS)
    Tumor tissue had much lower ratios of T regularity/CD8 T cells and CD4/CD8 T cells. Our findings showed that TEXomiR stimulates antitumor immune responses and that tumor-derived exosomes are an effective vehicle for miR-211 mimic delivery.
    Preclinical • Journal
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    CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • MIR211 (MicroRNA 211)
    11ms
    Transcriptomic profile induced by calcitriol in CaSki human cervical cancer cell line. (PubMed, PLoS One)
    Notably, among these calcitriol-regulated microRNAs are some involved in cervical cancer biology, such as miR-6129, miR-382, miR-655, miR-211, miR-590, miR-130a, miR-301a, and miR-1252. Collectively, these findings suggest that calcitriol exhibits a significant antitumor effect in this advanced cervical cancer model by blocking critical processes for tumor progression, underscoring the importance of maintaining adequate vitamin D nutritional status.
    Preclinical • Journal
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    MIR211 (MicroRNA 211) • KLK6 (Kallikrein Related Peptidase 6) • MIR130A (MicroRNA 130a) • MMP7 (Matrix metallopeptidase 7)
    12ms
    LncRNA TUSC7 Inhibits Cell Proliferation in Chronic Lymphocytic Leukemia by Modulating the miR-211-5p/SLC37A3 Axis. (PubMed, Kaohsiung J Med Sci)
    Further rescue experiments demonstrated that silencing SLC37A3 or upregulating miR-211-5p reversed the effects of TUSC7 elevation on cell proliferation and apoptosis. In conclusion, our findings suggest that TUSC7 regulates cell proliferation in CLL through the miR-211-5p/SLC37A3 axis.
    Journal
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    MIR211 (MicroRNA 211) • TUSC7 (Tumor Suppressor Candidate 7)