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    GENE:

    MIR21 (MicroRNA 21)

    i
    Other names: MIR21, MicroRNA 21, Hsa-MiR-21-5p, Hsa-MiR-21-3p, Hsa-Mir-21, MiRNA21, MiR-21
    3d
    Template-Directed RIG-I Agonist Assembly for Image-guided Targeted Cancer Immunotherapy. (PubMed, Mol Imaging Biol)
    Our template-driven approach brings RIG-I closer to becoming a clinically relevant target in oncology by specifically activating immune responses within tumor cells through systemic RIG-I agonist delivery.
    Journal
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    MIR21 (MicroRNA 21)
    5d
    Exosomal microRNAs as Central Regulators of Cancer Cachexia: Multi-Omics Insights into Muscle Wasting and Adipose Browning. (PubMed, J Proteome Res)
    This is the first integrated review linking exosomal miRNAs with proteomic and metabolomic signatures of cancer cachexia, offering a multiomics framework for biomarker discovery and therapeutic targeting. We highlight their potential as early biomarkers, therapeutic targets, and modulators of rehabilitation response, while outlining research gaps including limited clinical validation, intertumor heterogeneity, and the need for multiomics integration to advance translation into patient care.
    Review • Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • MIR155 (MicroRNA 155) • MIR21 (MicroRNA 21) • MIR122 (MicroRNA 122) • MIR181A1 (MicroRNA 181a-1) • MIR183 (MicroRNA 183)
    7d
    Chemopreventive Effects of Lycopene in miR-21 Knockout and Wild-Type Pancreatic Cancer Cells. (PubMed, Scientifica (Cairo))
    Treatment with 50 μM lycopene significantly reduced cell viability, colony formation, migration, and spheroid integrity and decreased intracellular reactive oxygen species (ROS) levels, with more pronounced effects in miR-21-deficient cells. These findings highlight the role of miR-21 in modulating lycopene sensitivity and support the potential of lycopene as an adjunctive therapeutic agent in pancreatic cancer.
    Journal
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    MIR21 (MicroRNA 21)
    10d
    Advances in epigenetics of gastric cancer. (PubMed, Oncol Rev)
    We further discuss translational applications of epigenetic biomarkers in liquid biopsies and targeted therapies (e.g., DNMT/HDAC inhibitors). Integrating multi-omics and epigenetic editing technologies may advance precision medicine in GC.
    Review • Journal
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    CDH1 (Cadherin 1) • MIR21 (MicroRNA 21) • HOTAIR (HOX Transcript Antisense RNA) • RUNX3 (RUNX Family Transcription Factor 3)
    10d
    Biomarkers of Common Molecular Dysregulation in Tumor Tissue and Peritumor Mucosa in Head and Neck SCC: Insights into Field Cancerization. (PubMed, Int J Mol Sci)
    The identification and validation of biomarkers reflecting this continuum could enable the establishment of molecular margins-improving risk assessment, reducing local recurrence, and advancing personalized oncologic surgery in HNSCC. Standardizing definitions and sampling protocols for "normal adjacent tissue" remains essential for future translational research.
    Review • Journal
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • MIR21 (MicroRNA 21) • ETS1 (ETS Proto-Oncogene 1) • MIR96 (MicroRNA 96) • E2F2 (E2F Transcription Factor 2) • MIR145 (MicroRNA 145)
    10d
    Gastric Cancer Epithelial-Mesenchymal Transition-The Role of Micro-RNA. (PubMed, Cancers (Basel))
    Several EMT-related miRNAs show consistent associations with invasion, metastasis, peritoneal dissemination, prognosis, and chemoresistance, and many are detectable in circulation. Overall, EMT-related miRNAs orchestrate gastric cancer cell plasticity and tumor-microenvironment crosstalk and represent promising biomarker and therapeutic candidates that warrant validation in prospective, subtype-stratified, and translational studies.
    Review • Journal
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    MET (MET proto-oncogene, receptor tyrosine kinase) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p) • TGFB1 (Transforming Growth Factor Beta 1) • MIR192 (MicroRNA 192) • MIR27A (MicroRNA 27a) • MIR17 (MicroRNA 17) • MIR23A (MicroRNA 23a) • MIR375 (MicroRNA 375) • MIR506 (MicroRNA 506) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • MIR106B (MicroRNA 106b) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR150 (MicroRNA 150) • MIR181A1 (MicroRNA 181a-1) • MIR200 (MicroRNA 200) • MIR204 (MicroRNA 204) • MIR218 (MicroRNA 218) • MIR26A1 (MicroRNA 26a-1) • MIR30A (MicroRNA 30a)
    10d
    Integrated Near-Infrared Light-Driven Janus Micromotor-Fluorescent Nanodiamond Dynamic Sensing Platform for Active Motion-Enhanced Biodetection. (PubMed, ACS Sens)
    Moreover, by incorporating a strand-displacement recognition strategy, quantitative detection of MUC1 was further demonstrated. By integrating self-propulsion with stable fluorescence signaling, the JMMs-FNDs sensing platform enabling efficient and highly sensitive fluorescence biodetection.
    Journal
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    MUC1 (Mucin 1) • MIR21 (MicroRNA 21)
    11d
    RNA-based therapies for colorectal cancer: targeting the β-catenin pathway via microbiota -modulated miRNAs. (PubMed, Front Mol Biosci)
    It also covers microbiota-host interactions, including bidirectional links between gut microbes and miRNAs, effects on intestinal homeostasis, and microbial metabolites that alter miRNA expression. Recent advances in RNA-based therapeutic strategies and progress in clinical trials are included to frame the current translational relevance.
    Review • Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • MIR21 (MicroRNA 21) • MIR200C (MicroRNA 200c) • MIR135B (MicroRNA 135b) • MIR145 (MicroRNA 145) • MIR203A (MicroRNA 203a)
    11d
    Investigation of the impact of image-guided radiotherapy selection on image registration results and non-coding RNAs for cervical cancer patients. (PubMed, Noncoding RNA Res)
    The results indicate that choosing bone and tumor landmarks as optimal registration points can improve the accuracy and efficacy of IGRT, leading to better treatment outcomes and reduced side effects. These findings offer scientific evidence and practical guidance for the utilization of IGRT in cervical cancer treatment, providing valuable technical support for future clinical practice.
    Journal
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    MIR21 (MicroRNA 21) • MIR34A (MicroRNA 34a-5p)
    11d
    CRISPR/Cas12a-nanozyme visual biosensor for detection of microRNA-21. (PubMed, Talanta)
    The activated Cas12a then cleaves the ssDNA linkers, releasing the nanozyme to catalyze a chromogenic reaction that yields a visible color change. This approach enables sensitive detection of miRNA-21 with a detection limit of 420.0 fM, providing a direct visual readout and demonstrating strong potential for point-of-care nucleic acid diagnostics.
    Journal
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    MIR21 (MicroRNA 21)
    13d
    DNAzyme-Powered Rolling Circle Amplification for the Synthesis of Hairpin DNA-Templated Fluorescent Copper Nanoclusters: A Label-Free miRNA Sensing Platform. (PubMed, Anal Chem)
    In addition, the biosensor was used to analyze the expression level of miRNA-21 in human serum and various cell lysates. The proposed detection method features simple design, low cost, and high sensitivity and eliminates the need for fluorophore labeling, holding great potential for clinical diagnostics.
    Journal
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    MIR21 (MicroRNA 21)