MIR20B (MicroRNA 20b)

The miRNA-mRNA interactions were validated using real-time PCR in independent patient cohorts. This study revealed a complex molecular landscape of mCLM within the hepatic microenvironment and novel miRNA-mRNA interactions with potential prognostic and therapeutic implications.

Functional analysis of target genes, CCND1 as a key gene through which miR-20b enhanced radiosensitivity in HPV+ HNSCC. In this study, our results suggest that M1 exos, enriched with miR-20b, regulate the DNA damage repair pathway in tumor cells by targeting CCND1, enhancing the radiosensitivity of HPV+ HNSCC.

miR-20b-3p inhibition significantly reduces the invasive and metastatic capabilities of EOC cells resulting from a reduction in SNHG29 expression. Our study revealed that SNHG29 may be a promising prognostic factor and therapeutic target for EOC.

Exosomal miR-20b-5p represses MASTL, remodels PI3K-AKT, and attenuates Ara-C responses in AML models. Seed-mutant reporters and 3'-UTR-independent rescue support target specificity. Findings are mechanistic and hypothesis-generating; clinical relevance requires confirmation in primary blasts and prospective validation.

Hsa-miR-155-5p expression in untreated primary breast tissue may be a valuable biomarker for predicting BCBR. A personalized escalation strategy is expected to be helpful in conquering brain metastases.

This study suggests that specific miRNAs correlate with metals in PDAC, such as miR-361-3p with Cu and miR-216a-5p with Mn, hinting at a potential role of metal homeostasis in tumour-related pathways. However, these findings warrant further validation and functional studies, and may provide novel insights for biomarker development and therapeutic strategies in PDAC.

The cervical microbiome undergoes changes during menopause, and may influence disease progression by interacting with metabolites, cytokines, and miRNAs. These results highlight the potential for personalized medicine for cervical cancer that is tailored to different age groups.

According to the Gene Expression Profiling Interactive Analysis (GEPIA) database results, the target genes AFAP1L1, GPT2, PPP1R12B, PRNP and SGIP1 in the three-miRNA panel were good candidates. Our three-miRNA panel (hsa-miR-20b-5p, hsa-miR-200b-3p and hsa-miR-106a-5p) is anticipated to be a promising non-invasive biomarker for NPC screening and diagnosis.

The results of this study indicate that microRNA-mediated regulation of DUSP2 in hematologic and solid cancers appears to be a plausible mechanism that contributes to the dysregulation of MAP kinase signaling pathways in cancer by impairing negative feedback regulation. The data provide a solid foundation for future studies to investigate the consequences of regulation of DUSP function in cancer in more depth.

CCND1 expression correlated with the expression of its transcriptional activator STAT3 in MCF7 cells and tumor tissues. Overall, the study suggests NEAT1/hsa-miR-20b-5p/STAT3 axes as a potential biomarker in breast tumors.

Our exploration of upstream regulators revealed six and one reliable transcription factors for CCNJL and SLC29A4, respectively. This study delved into common biomarkers between STC and CRC, and developed a reliable prognostic signature for CRC.

Their ability to modulate multiple onco-genic and tumour-suppressive pathways highlights their potential as therapeutic targets or bi-omarkers in the context of personalized cancer treatment strategies. This review provides a com-prehensive depth of current knowledge while proposing avenues for future research into the ther-apeutic manipulation of these miRNAs in combating cancer.